Investigation of mammalian and viral Interleukin-10 family members during cytomegalovirus infection

Autor: Stacey, Maria A.

Human cytomegalovirus (HCMV) infection in newborns and immunocompromised individuals with immature or deficient immune systems can cause life-threatening diseases. The clinical and subsequent economical burden of HCMV infection led the US Institute o

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.567418

Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG

Autor: Rigaud, Stéphanie ^*, Lopez-Granados, Eduardo ^*, Sibéril, Sophie, Gloire, Geoffrey, Lambert, Nathalie, Lenoir, Christelle, Synaeve, Cindy, Stacey, Maria, Fugger, Lars, Stephan, Jean-Louis, Fischer, Alain, Picard, Capucine, Durandy, Anne, Chapel, Helen, Latour, Sylvain ^*

Publikováno v: In Blood 14 July 2011 118(2):252-261

IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea

Autor: McLaren, James, Clement, Mathew, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J., Ladell, Kristin, Price, David A., Humphreys, Ian R.

Candidate vaccines designed to generate T cell–based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector memory T cell responses. This limitation can be overcome using recombinant strains of CMV.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c5032add9a16527bfc8169e8cd49ccbb
https://orca.cardiff.ac.uk/id/eprint/118404/1/jimmunol.1701757.full.pdf

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

Autor: Clement, Mathew, Marsden, Morgan, Stacey, Maria A., Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana, Scurr, Martin J., Ghazal, Peter, Weaver, Casey T., Carlesso, Gianluca, Clare, Simon, Jones, Simon A., Godkin, Andrew, Jones, Gareth W., Humphreys, Ian R.

Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006050 (2016)
PLoS Pathogens
Clement, M, Marsden, M, Stacey, M A, Abdul-Karim, J, Gimeno Brias, S, Costa Bento, D, Scurr, M J, Ghazal, P, Weaver, C T, Carlesso, G, Clare, S, Jones, S A, Godkin, A, Jones, G W & Humphreys, I R 2016, ' Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence ', PLoS Pathogens, vol. 12, no. 12, pp. e1006050 . https://doi.org/10.1371/journal.ppat.1006050
Clement, M, Marsden, M, Stacey, M, Abdul-Karim, J, Brias, S G, Bento, D F C, Scurr, M, Weaver, C, Carlesso, G, Clare, S, Jones, S, Godkin, A, Ghazal, P, Jones, G W & Humphreys, I 2016, ' Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence ', PLoS Pathogens, vol. 12, no. 12, e1006050 . https://doi.org/10.1371/journal.ppat.1006050

CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6e20157e04085b90a71d6c37f2baa265
https://doaj.org/article/7fe395ac2dd442b6bb7558097586ab3e

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