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Phosphorothioate backbone modification modulates macrophage activation by CpG DNA

Autor: Sester, D. P., Naik, S., Shannon Beasley, Hume, D. A., Stacey, K. J.

Publikováno v: Sester, D P, Naik, S, Beasley, S J, Hume, D A & Stacey, K J 2000, ' Phosphorothioate backbone modification modulates macrophage activation by CpG DNA ', Journal of Immunology, vol. 165, no. 8, pp. 4165-73 .
Scopus-Elsevier

Macrophages respond to unmethylated CpG motifs present in nonmammalian DNA. Stabilized phosphorothioate-modified oligodeoxynucleotides (PS-ODN) containing CpG motifs form the basis of immunotherapeutic agents. In this study, we show that PS-ODN do no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::569eb14119e9042e043485c005a71c28
https://www.pure.ed.ac.uk/ws/files/12628410/Phosphorothioate_backbone_modification_modulates_macrophage_activation_by_CpG_DNA.pdf

RNA synthesis inhibition stabilises urokinase mRNA in macrophages

Autor: Stacey, K J, Nagamine, Y, Hume, D A

Publikováno v: Stacey, K J, Nagamine, Y & Hume, D A 1994, ' RNA synthesis inhibition stabilises urokinase mRNA in macrophages ', FEBS Letters, vol. 356, no. 2-3, pp. 311-3 .

Urokinase-type plasminogen activator (uPA) mRNA is induced in macrophages by the lineage specific growth factor CSF-1. Upon removal of CSF-1 from bone marrow-derived macrophages (BMM), uPA mRNA decayed with a half-life of 2 h. If RNA synthesis inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::f1f50f74b0f316b6431e1ec014528cf3
https://hdl.handle.net/20.500.11820/dfdebc82-f628-4b05-8f9c-0b48c544f9ff

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Autor: Cassady, A I, Stacey, K J, Nimmo, K A, Murphy, K M, von der Ahe, D, Pearson, D, Botteri, F M, Nagamine, Y, Hume, D A

Publikováno v: Cassady, A I, Stacey, K J, Nimmo, K A, Murphy, K M, von der Ahe, D, Pearson, D, Botteri, F M, Nagamine, Y & Hume, D A 1991, ' Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig ', Nucleic Acids Research, vol. 19, no. 24, pp. 6839-47 .

The 5' flanking regions of the mouse and pig urokinase plasminogen activator (uPA) genes were sequenced and sequence homology interrupted by repeat elements was found to extend to -4.6kb in pig and -6.6kb in mouse. A transient transfection procedure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::47251198e15e47571b5d16787fceb807
https://hdl.handle.net/20.500.11820/99793545-630d-46eb-b5f9-45a611deaf95