Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stéphanie Vauléon"'
Autor:
Michael Steurer, Marco Montillo, Lydia Scarfò, Francesca R. Mauro, Johannes Andel, Sophie Wildner, Livio Trentin, Ann Janssens, Sonja Burgstaller, Anna Frömming, Thomas Dümmler, Kai Riecke, Matthias Baumann, Diana Beyer, Stéphanie Vauléon, Paolo Ghia, Robin Foà, Federico Caligaris-Cappio, Marco Gobbi
Publikováno v:
Haematologica, Vol 104, Iss 10 (2019)
Olaptesed pegol (NOX-A12) is a pegylated structured L-oligoribonucleotide that binds and neutralizes CXCL12, a chemokine tightly regulating the life cycle of chronic lymphocytic leukemia cells. The resulting inhibition of CXCR4 and CXCR7 signaling re
Externí odkaz:
https://doaj.org/article/e87d8b780fc74f3e8d8ce9bfbe956c1b
Autor:
Inge A. Ivens, Anna-Lena Frisk, Katrin Gutberlet, David Banczyk, Shawna Jackman, Stéphanie Vauléon
Publikováno v:
Toxicologic Pathology
BAY 94-9027 (Jivi) is a site-specifically PEGylated human B-domain-deleted (BDD) recombinant factor VIII (FVIII), with a 60 kDa branched PEG molecule attached. The nonclinical safety of BAY 94-9027 was evaluated in a toxicology program that included
Autor:
Stephanie Vauleon, Katharina Schutz, Benoit Massonnet, Nanda Gruben, Marianne Manchester, Alessandra Buehler, Eginhard Schick, Lauren Boak, David J. Hawellek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Huntington’s disease (HD) is caused by a cytosine adenine guanine-repeat expansion in the huntingtin gene. This results in the production of toxic mutant huntingtin protein (mHTT), which has an elongated polyglutamine (polyQ) stretch near
Externí odkaz:
https://doaj.org/article/bad2f4a1d56e443989a5c40b6c57ac69
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 7:912-931
During the past decade, RNA has become a focus of investigation into new therapeutic schemes: antisense RNA, interfering RNA and trans-cleaving ribozymes are used to silence undesired gene expression. As an additional option with its own therapeutic
Publikováno v:
bchm. 388:743-746
Reversible chemistry, allowing for chain-forming as well as chain-breaking steps, is important for biological self-organization. In this context, ribozymes, catalyzing both RNA cleavage and ligation, may have significantly contributed to extending th
Publikováno v:
ChemBioChem. 6:2158-2162
Publikováno v:
Biochemical and biophysical research communications. 363(1)
Over the past two decades, the structure and mechanism of catalytic RNA have been extensively studied; now ribozymes are understood well enough to turn them into useful tools. After we have demonstrated the twin ribozyme mediated insertion of additio
Publikováno v:
The FEBS journal. 272(17)
In recent years major progress has been made in elucidating the mechanism and structure of catalytic RNA molecules, and we are now beginning to understand ribozymes well enough to turn them into useful tools. Work in our laboratory has focused on the
Akademický článek
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Publikováno v:
ChemBioChem; Dec2005, Vol. 6 Issue 12, p2158-2162, 0p