Vasoinhibins Prevent Bradykinin-Stimulated Endothelial Cell Proliferation by Inactivating eNOS via Reduction of both Intracellular Ca2+ Levels and eNOS Phosphorylation at Ser1179

Autor: Carmen Clapp, Stéphanie Thebault, Gonzalo Martínez De la Escalera, Fernando López-Casillas, Luis Vaca, David Arredondo Zamarripa, Gabriel Nava, Celina García, Carmen González

Publikováno v: Pharmaceuticals, Vol 4, Iss 7, Pp 1052-1069 (2011)

Vasoinhibins, a family of antiangiogenic peptides derived from prolactin proteolysis, inhibit the vascular effects of several proangiogenic factors, including bradykinin (BK). Here, we report that vasoinhibins block the BK-induced proliferation of bo

Externí odkaz: https://doaj.org/article/559022d0b1704bbca5bdfa11c8ee9dbd

Minireview: Insights into the role of TRP channels in the retinal circulation and function

Autor: Stéphanie Thebault

Publikováno v: Neuroscience letters. 765

Consistent with their wide distribution throughout the CNS, transcripts of all transient receptor potential (TRP) cation channel superfamily members have been detected in both neuronal and non-neuronal cells of the mammalian retina. Evidence shows th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf00526144a1c4007f6009025c3877ce
https://pubmed.ncbi.nlm.nih.gov/34634394

TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice

Autor: Luis Concha, Ataúlfo Martínez Torres, Maricruz Orduña Ríos, Nicole Marilú Hernández Godínez, Wolfgang Liedtke, Stéphanie Thebault, Ramsés Noguez Imm, Ana María Bautista Cortes

A better understanding of the molecular and cellular mechanisms involved in retinal hydro-ionic homeostasis imbalance during diabetic macular edema (DME) is needed to gain insights into retinal physio(patho)logy that will help elaborating innovative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0223f99dde3417cc64d803efc13d14

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: Diabetic milieu makes a difference

Autor: Alessandra Fiorio Pla, Michela Bernardini, Natalia Prevarskaya, Ana María Bautista Cortes, Wolfgang Liedtke, Osvaldo Vázquez Ruíz, David Arredondo Zamarripa, Stéphanie Thebault, Carmen Clapp, Fernando López-Casillas, Ramsés Noguez Imm, Dimitra Gkika

Publikováno v: Scientific Reports
Scientific Reports, 2017, 7 (1), pp.13094. ⟨10.1038/s41598-017-13621-8⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f7f320d5dd96ccc35ea14f78c389eb
http://hdl.handle.net/2318/1651799

The Hormone Prolactin Is a Novel, Endogenous Trophic Factor Able to Regulate Reactive Glia and to Limit Retinal Degeneration

Autor: Edith Arnold, Gerardo Rojas-Piloni, Andrés Quintanar-Stephano, Carmen Clapp, Nadine Binart, Norma Adán, Stéphanie Thebault, David Arredondo Zamarripa, Miguel Condés-Lara, German d Baeza-Cruz, Gonzalo Martínez de la Escalera

Publikováno v: The Journal of Neuroscience. 34:1868-1878

Retinal degeneration is characterized by the progressive destruction of retinal cells, causing the deterioration and eventual loss of vision. We explored whether the hormone prolactin provides trophic support to retinal cells, thus protecting the ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6dc80745d6c8c3f19b4428669a4a44
https://doi.org/10.1523/jneurosci.2452-13.2014