Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo

Autor: Bridlin Barckmann, Stéphanie Pierson, Jérémy Dufourt, Catherine Papin, Claudia Armenise, Fillip Port, Thomas Grentzinger, Séverine Chambeyron, Grégory Baronian, Jean-Pierre Desvignes, Tomaz Curk, Martine Simonelig

Publikováno v: Cell Reports, Vol 12, Iss 7, Pp 1205-1216 (2015)

The Piwi-interacting RNA (piRNA) pathway plays an essential role in the repression of transposons in the germline. Other functions of piRNAs such as post-transcriptional regulation of mRNAs are now emerging. Here, we perform iCLIP with the PIWI prote

Externí odkaz: https://doaj.org/article/62baf30bff654c508adeac150b41c93f

Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch

Autor: Martine Simonelig, Stéphanie Pierson, Nagraj Sambrani, Elmar Wahle, Christiane Rammelt, Claudia Temme, Michael Götze, Christian Ihling, Andrea Sinz, Jeremy Dufourt

Publikováno v: RNA
RNA, 2017, 23 (10), pp.1552-1568. ⟨10.1261/rna.062208.117⟩
RNA, Cold Spring Harbor Laboratory Press, 2017, 23 (10), pp.1552-1568. ⟨10.1261/rna.062208.117⟩

Translational repression of maternal mRNAs is an essential regulatory mechanism during early embryonic development. Repression of theDrosophila nanosmRNA, required for the formation of the anterior-posterior body axis, depends on the protein Smaug bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256aff44cf40487ec1d6b407282e95fc
https://doi.org/10.1261/rna.062208.117

Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

Autor: Steven Carberry, Martine Simonelig, Martine Oloko, Maelle Bellec, Teresa Gidaro, Vincent Mouly, George Dickson, Pierre Klein, Gillian Butler-Browne, Nicolas Barbezier, Claude Jardel, Stéphanie Pierson, Capucine Trollet, Bodo Moritz, Aymeric Chartier, Paul Dowling, Laurie Maynadier, Kay Ohlendieck, François Casas

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2015, 11 (3), pp.e1005092. 〈10.1371/journal.pgen.1005092〉
PLoS Genetics, Public Library of Science, 2015, 11 (3), pp.e1005092. ⟨10.1371/journal.pgen.1005092⟩
Plos Genetics 3 (11), . (2015)
PLoS Genetics, Public Library of Science, 2015, 11 (3), pp.e1005092
PLoS Genetics, Vol 11, Iss 3, p e1005092 (2015)
PLoS Genetics, 2015, 11 (3), pp.e1005092. ⟨10.1371/journal.pgen.1005092⟩

Oculopharyngeal muscular dystrophy (OPMD), a late-onset disorder characterized by progressive degeneration of specific muscles, results from the extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). While the roles of PABPN1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff5c281f9c302402997dd1099b34588
https://hal.sorbonne-universite.fr/hal-01231399/file/journal.pgen.1005092.pdf

Orb prevents autophagy in the Drosophila germline through translational repression of Atg12 mRNA

Autor: Martine Simonelig, Christelle Dantec, Stéphanie Pierson, Isabelle Busseau, Dany Severac

Drosophila Orb, the homologue of vertebrate CPEB is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb has also an essential function during early oogenesis which has not be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c85af752b3d83c2b77db7075dce7ff

What to Do When No One Has a Clue : Advice for the Brave New World

Autor: Stephanie Pierson, Barbara Harrison

Is it okay to text bad news? What do you do if you and your intended already have hyphenated last names? Is it gauche to take home leftovers from a four-star restaurant? Should you admit you are getting your MBA online? Is it okay to ask a lesbian ho