Evaluation of borinic acids as new, fast hydrogen peroxide–responsive triggers

Autor: Blaise Gatin-Fraudet, Roxane Ottenwelter, Thomas Le Saux, Stéphanie Norsikian, Mathilde Pucher, Thomas Lombès, Aurélie Baron, Philippe Durand, Gilles Doisneau, Yann Bourdreux, Bogdan I. Iorga, Marie Erard, Ludovic Jullien, Dominique Guianvarc’h, Dominique Urban, Boris Vauzeilles

Publikováno v: Proc Natl Acad Sci U S A

Significance Hydrogen peroxide plays an important role in the fine balance between physiological and pathological processes. To detect this diffusible small molecule, we expanded the scope of organic triggers in developing borinic acids as an alterna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279da2bb85fc6f0a688ef6c3cb47ece3
https://europepmc.org/articles/PMC8685692/

Total Synthesis of Tiacumicin B: Implementing Hydrogen Bond Directed Acceptor Delivery for Highly Selective β‐Glycosylations

Autor: Cédric Tresse, Guillaume Masson, Grégory Genta-Jouve, Jean-Marie Beau, Emmanuel Roulland, Louis Jeanne-Julien, Vincent Servajean, Stéphanie Norsikian, Marc François-Eude

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (16), pp.6612-6616. ⟨10.1002/anie.202000231⟩
Angewandte Chemie
Angewandte Chemie, Wiley-VCH Verlag, 2020, 132 (16), pp.6674-6678. ⟨10.1002/ange.202000231⟩
Angewandte Chemie International Edition, 2020, 59 (16), pp.6612-6616. ⟨10.1002/anie.202000231⟩

International audience; We report a total synthesis of tiacumicin B, a natural macrolide whose remarkable antibiotic properties are used to treat severe intestinal infections. The strategy is in part based on our experience of the synthesis of the ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c19af86d0ae67b1c097a7bc0a26f5ba
https://hal.archives-ouvertes.fr/hal-02560216

From Chitin to α-Glycosides of N -Acetylglucosamine Using Catalytic Copper Triflate in a Heated Sealed-Vessel Reactor

Autor: Stéphanie Norsikian, Jean-Marie Beau, Dany Frem, Dominique Urban

Publikováno v: European Journal of Organic Chemistry. 2017:5094-5101

The selective preparation of α-glycosides of GlcNAc has been accomplished using a direct copper(II) triflate-catalyzed glycosylation between the α-D-glucosamine pentaacetate, readily available from chitin, and a range of alcohol acceptors. The α-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0489aa529fdfe797a6a2360686c154ed
https://doi.org/10.1002/ejoc.201700933

Iron(III)-Triflate-Catalyzed Multiple Glycosylations with Peracetylated β-d-Glucosamine

Autor: Jean-Marie Beau, Amandine Xolin, François-Didier Boyer, Stéphanie Norsikian

Publikováno v: European Journal of Organic Chemistry. 2016:3408-3418

Direct multiple glycosylations of thioaryl and propargyl mannopyranosides with peracetylated β-d-glucosamine have been carried out using catalytic iron(III) triflate as a promoter in the presence of 2,4,6-tri-tert-butylpyrimidine under microwave irr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43aef3a349fbe73f117d68183db7b4e1
https://doi.org/10.1002/ejoc.201600457

Stereocontrolled glycoside synthesis by activation of glycosyl sulfone donors with scandium( iii ) triflate

Autor: Romain Losa, Amandine Xolin, Aicha Kaid, Jean-Marie Beau, Stéphanie Norsikian, Cédric Tresse, François-Didier Boyer

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (2), pp.325-335. ⟨10.1039/c7ob02792c⟩

International audience; The activation of aryl glycosyl sulfone donors has been achieved using scandium(III) triflate and has led to the selective preparation of alpha-mannosides resulting from a post-glycosylation anomerization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996a9abaf596695ae54af979a2aa0708
https://hal.archives-ouvertes.fr/hal-02324785