Výsledky vyhledávání - "Stéphanie Letast"

Akademický článek

Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Autor: Camille Blouet, Stéphanie Letast, Thomas Robert, Stéphane Bach, Noël Pinaud, Nicolas Joubert, Marie-Claude Viaud-Massuard, Jean Guillon, Cédric Logé, Caroline Denevault-Sabourin

Publikováno v: Molbank, Vol 2023, Iss 4, p M1735 (2023)

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structu

Externí odkaz: https://doaj.org/article/eb3c8596c9f24290a70b6f4142e78806

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Akademický článek

Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment–Drug Conjugates (FDCs)

Autor: Louis Jolivet, Imène Ait Mohamed Amar, Catherine Horiot, Fanny Boursin, Cyril Colas, Stéphanie Letast, Caroline Denevault-Sabourin, Emilie Allard-Vannier, Nicolas Joubert, Nicolas Aubrey

Publikováno v: Pharmaceutics, Vol 14, Iss 8, p 1524 (2022)

Antibody–drug conjugates (ADCs) derived from a full immunoglobulin-G (IgG) are associated with suboptimal solid-tumor penetration and Fc-mediated toxicities. Antibody fragment–drug conjugates (FDCs) could be an alternative. Nevertheless, innovati

Externí odkaz: https://doaj.org/article/15b7c6d9bacf44478b679c4b9bf364c0

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Akademický článek

Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Autor: Valentina Corvaglia, Imène Ait Mohamed Amar, Véronique Garambois, Stéphanie Letast, Aurélie Garcin, Céline Gongora, Maguy Del Rio, Caroline Denevault-Sabourin, Nicolas Joubert, Ivan Huc, Philippe Pourquier

Publikováno v: Pharmaceuticals, Vol 14, Iss 7, p 624 (2021)

Inhibition of protein–DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique oligoamide-based foldamers that adopt single helical conformations and mimic the negatively charg

Externí odkaz: https://doaj.org/article/cf02bd029f4647c98225f8673b64d484

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Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment–Drug Conjugates (FDCs)

Autor: Aubrey, Louis Jolivet, Imène Ait Mohamed Amar, Catherine Horiot, Fanny Boursin, Cyril Colas, Stéphanie Letast, Caroline Denevault-Sabourin, Emilie Allard-Vannier, Nicolas Joubert, Nicolas

Publikováno v: Pharmaceutics; Volume 14; Issue 8; Pages: 1524

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::66c0f7274d315b7b9af5c4ab1244e1f9

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Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Autor: Ivan Huc, Maguy Del Rio, Céline Gongora, Philippe Pourquier, Caroline Denevault-Sabourin, Véronique Garambois, Valentina Corvaglia, Nicolas Joubert, Aurélie Garcin, Stéphanie Letast, Imène Ait Mohamed Amar

Publikováno v: Pharmaceuticals
Pharmaceuticals, MDPI, 2021, 14 (7), pp.624. ⟨10.3390/ph14070624⟩
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 624, p 624 (2021)
Pharmaceuticals, 2021, 14 (7), pp.624. ⟨10.3390/ph14070624⟩

International audience; Inhibition of protein–DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique oligoamide-based foldamers that adopt single helical conformations and mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561f3c6089555caba5efc96bc4ce2a45
https://hal.archives-ouvertes.fr/hal-03456576

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Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate

Autor: Imene Ait Mohamed Amar, Steve Huvelle, Emmanuel Douez, Stéphanie Letast, Sylvain Henrion, Marie-Claude Viaud-Massuard, Nicolas Aubrey, Emilie Allard-Vannier, Nicolas Joubert, Caroline Denevault-Sabourin

Publikováno v: European Journal of Medicinal Chemistry. 229:114063

Antibody-drug conjugates (ADCs) are targeted therapies, mainly used in oncology, consisting in a three-component molecular architecture combining a highly potent drug conjugated via a linker onto a monoclonal antibody (mAb), designed for the selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faaa5ea5206311fac941fcd83fc247c5
https://doi.org/10.1016/j.ejmech.2021.114063

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Impact of cathepsin B-sensitive triggers and hydrophilic linkers onin vitroefficacy of novel site-specific antibody–drug conjugates

Autor: Nicolas Joubert, Stéphanie Letast, Cyril Colas, Marie-Claude Viaud-Massuard, Eva Lles, Camille Martin, Christel Larbouret, Inmaculada Viéitez-Villemin, Emilie Allard-Vannier, Anaïs Rousseau, Marie Brachet-Botineau, Francesca Bryden

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2018, 16 (11), pp.1882-1889. ⟨10.1039/c7ob02780j⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (11), pp.1882-1889. 〈10.1039/c7ob02780j〉
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (11), pp.1882-1889. ⟨10.1039/c7ob02780j⟩

Herein we describe the synthesis and evaluation of four novel HER2-targeting, cathepsin B-sensitive antibody-drug conjugates bearing a monomethylauristatin E (MMAE) cytotoxic payload, constructed via the conjugation of cleavable linkers to trastuzuma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a68e540255ee8e685d66c7de56ab664
https://doi.org/10.1039/c7ob02780j

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Site-Specific Conjugation of Auristatins onto Engineered scFv Using Second Generation Maleimide to Target HER2-positive Breast Cancer in Vitro

Autor: Francesca Bryden, Stéphanie Letast, Nils Collinet, Igor Chourpa, Nicolas Joubert, Cyril Colas, Emilie Allard-Vannier, Camille Martin, Nicolas Aubrey, Zineb Lakhrif, Isabelle Dimier-Poisson, Marie-Claude Viaud-Massuard

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2018, 29 (11), pp.3516-3521. ⟨10.1021/acs.bioconjchem.8b00668⟩
Bioconjugate Chemistry, American Chemical Society, 2018, ⟨10.1021/acs.bioconjchem.8b00668⟩
Bioconjugate Chemistry, 2018, 29 (11), pp.3516-3521. ⟨10.1021/acs.bioconjchem.8b00668⟩

International audience; Antibody-drug conjugates (ADC) are spearheading vectorized chemotherapy against cancer, with 4 FDA-approved ADCs and 79 in clinical trials. However, most ADCs are produced using a stochastic bioconjugation method, target hemat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d653a50b401689c4d58405719505ca8
https://hal-univ-tours.archives-ouvertes.fr/hal-01907352

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