Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Stéphanie Le Guen"'
Publikováno v:
British Journal of Pharmacology. 140:831-838
Little is known about the cellular effects induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), although changes in gene expression have been observed following treatments with other psychostimulants. Thus, the aim of this study was to inves
Autor:
Annie Cupo, Corinne Canestrelli, Rafael Maldonado, Magdalena Mas Nieto, Huixiong Chen, Marie-Claude Fournie-Zaluski, Bernard P. Roques, Florence Noble, Stéphanie Le Guen
Publikováno v:
Pain. 104:139-148
The discovery that the endogenous morphine-like peptides named enkephalins are inactivated by two metallopeptidases, neutral endopeptidase and aminopeptidase N, which can be blocked by dual inhibitors, represents a promising way to develop ‘physiol
Autor:
Jean-Marie Besson, Marie-Claude Fournie-Zaluski, Jaroslava Buritova, Stéphanie Le Guen, Bernard P. Roques
Publikováno v:
European Journal of Pain. 7:241-249
The effects of the S enantiomer of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, alone or in combination with a functional NMDA receptor antagonist, (+)-HA966 were studied on the spinal c-Fos protein expression in the carrageenan mo
Publikováno v:
European Journal of Neuroscience. 17:2425-2437
We have recently shown concurrent changes in behavioural responses and c-Fos protein expression in the central nervous system in both naive and morphine-dependent rats after systemic administration of the opioid antagonist naloxone. However, because
Autor:
Jaroslava Buritova, Stéphanie Le Guen, Gwénaëlle Catheline, Jean Marie Besson, Marie Claude Fournie-Zaluski, Bernard P. Roques
Publikováno v:
Brain Research. 967:106-112
We have previously shown that RB101, a dual inhibitor of enkephalin-degrading enzymes, decreased carrageenin-evoked c-Fos protein expression at the spinal cord level in awake rats. Moreover, we have also shown that c-Fos expression is a useful marker
Publikováno v:
The Journal of Comparative Neurology. 427:285-301
This study examined the possibility that a tonic activity in the endogenous opioid systems (EO systems) exists in animals under normal conditions. In a first set of experiments, concurrent changes in behavioral responses and in the numbers of c-Fos-l
Publikováno v:
European Journal of Pharmacology. 373:1-11
This study investigated the contribution of NMDA receptors to the development of tolerance to the antinociceptive properties of morphine at the level of the spinal cord dorsal horn. The expression of c-Fos protein following intraplantar (i.pl.) injec
Publikováno v:
European Journal of Pharmacology. 370:287-296
In an attempt to study the anti-inflammatory and the antinociceptive effects of a kappa1-opioid receptor agonist (U-69,593: trans-3,4-dichloro-N-methyl-N-[7-(1-pyrrolidinyl)cycloexil]benzene acetamide methanesulfonate), we used a combination of the m
Publikováno v:
Brain Research. 824:105-111
This study performed in freely moving rats evaluated the ability of specific opioid receptor antagonists to reverse the inhibitory effects of morphine on carrageenin-induced c-Fos expression in the spinal cord. Our study focused on the superficial do
Publikováno v:
Pain. 80:347-357
The long-term changes in Fos like-immunoreactivity (Fos-LI) in the dorsal horn of the spinal cord following various peripheral nerve lesions remain controversial. This study considers such an approach with chronic constriction injury rats (CCI: loose