Výsledky vyhledávání - "Stéphanie Julien"

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

Autor: Karl-Heinz Krause, Stéphanie Julien, Marilena Colaianna, Sieto Bosgra, Mathurin Baquié, Sten Ilmjärv, Giorgia Pallocca, Hedi Peterson, Ilse Kern, Jan G. Hengstler, Marcel Leist, Agapios Sachinidis

Publikováno v: Archives of Toxicology
Archives of Toxicology, Vol. 91, No 1 (2017) pp. 365-391
Archives of Toxicology, 1, 91, 365-391

Identification of neurotoxic drugs and environmental chemicals is an important challenge. However, only few tools to address this topic are available. The aim of this study was to develop a neurotoxicity/developmental neurotoxicity (DNT) test system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4222ba7375609ff92e87216ba7a41aab
http://europepmc.org/articles/PMC5225183

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Embryonic Stem Cell-Based Screen for Small Molecules: Cluster Analysis Reveals Four Response Patterns in Developing Neural Cells

Autor: Stéphanie Julien, Christophe Combescure, Ilse Kern, Luc Stoppini, Christoph van Thriel, Antoine Poncet, Ruodan Xu, Olivier Preynat-Seauve, Karl-Heinz Krause, Mathurin Baquié, David M. Suter

Publikováno v: Current Medicinal Chemistry; Vol 20
Current Medicinal Chemistry, Vol. 20, No 5 (2013) pp. 710-23
Current Medicinal Chemistry

Neural differentiation of embryonic stem cells (ESC) is considered a promising model to perform in vitro testing for neuroactive and neurotoxic compounds. We studied the potential of a dual reporter murine ESC line to identify bioactive and/or toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb616d765336278a3239d76751a652d2

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The long-term survival of in vitro engineered nervous tissue derived from the specific neural differentiation of mouse embryonic stem cells

Autor: Igor Charvet, Lars Sundstrom, Stéphanie Julien, Michel Dubois-Dauphin, Luc Stoppini, Nicolas Toni

Publikováno v: Biomaterials

Embryonic stem cells (ESCs) offer attractive prospective as potential source of neurons for cell replacement therapy in human neurodegenerative diseases. Besides, ESCs neural differentiation enables in vitro tissue engineering for fundamental researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c097675c6c9a6445775fce2e9358a5d9
https://doi.org/10.1016/j.biomaterials.2010.06.017

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Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5

Autor: Michel Dubois-Dauphin, Stéphanie Julien, N. Marq-Lin, Silvia Sorce, Karl-Heinz Krause, Jérôme Bonnefont, Ivan Rodriguez

Publikováno v: British Journal of Pharmacology. 160:311-321

Background and purpose: The chemokine receptor CCR5 is well known for its function in immune cells; however, it is also expressed in the brain, where its specific role remains to be elucidated. Because genetic factors may influence the risk of develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::542f904284bb012bcf29659a60de9dc0
https://doi.org/10.1111/j.1476-5381.2010.00697.x

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Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Autor: Tanja Waldmann, Agapios Sachinidis, C. van Thriel, Marcel Leist, Jan G. Hengstler, Nadine Dreser, Sunniva Foerster, Karl-Heinz Krause, Joost Westerhout, Giorgia Pallocca, Stéphanie Julien, Sieto Bosgra, Bastian Zimmer

Publikováno v: Archives of Toxicology, Vol. 88, No 5 (2014) pp. 1109-1126
Archives of Toxicology, 5, 88, 1109-1126
Archives of Toxicology

Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10110ed3cb5e364008815d998e19e22e
https://doi.org/10.1007/s00204-014-1231-9

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Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay

Autor: Andras Dinnyes, Csilla Nemes, Maxime Feyeux, Morten Albrechtsen, Stéphanie Julien, Ruodan Xu, Karl-Heinz Krause

Publikováno v: The AAPS Journal, Vol. 16, No 3 (2014) pp. 400-412

Differentiation of pluripotent stem cells, PSCs, towards neural lineages has attracted significant attention, given the potential use of such cells for in vitro studies and for regenerative medicine. The present experiments were designed to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f68886ab8eb80454e0f640298eff79
https://pubmed.ncbi.nlm.nih.gov/24557747

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Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

Publikováno v: Archives of Toxicology, Vol. 87, No 1 (2013) pp. 123-43
Archives of Toxicology 87 (2013), Nr. 1
Archives of Toxicology; Vol 87
Archives of Toxicology, 1, 87, 123-143
Archives of Toxicology

Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell differentiation or communicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a602b12a62e475fcb7126908e3355f8
https://archive-ouverte.unige.ch/unige:32464

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Stem cell-derived neurons grafted in the striatum are expelled out of the brain after chronic cortical stroke

Autor: Stéphanie Julien, Michel Dubois-Dauphin

Publikováno v: Stroke, a journal of cerebral circulation

Background and Purpose— In humans and rodents, cortical stroke can lead to cortex atrophy in long-term survivors. In the rodent, fetal brain neural precursors or stem cell–derived neurons grafted in the stroke-lesioned brain integrate successfull

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f141c0749716c5418f79bcab9d9a8ce2
https://pubmed.ncbi.nlm.nih.gov/20576956

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