Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly

Autor: Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin, Jean-Pol Frippiat

Publikováno v: Immunity & Ageing, Vol 20, Iss 1, Pp 1-17 (2023)

Abstract Background The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration missions, such as the deployment of the Lunar Gateway and possible interplanetary

Externí odkaz: https://doaj.org/article/5487ef889dc74769913ee3cad7c1e2d4

B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation

Autor: Julie Bonnefoy, Bjorn Baselet, Dominique Moser, Stéphanie Ghislin, Silvana Miranda, Elodie Riant, Randy Vermeesen, Annekathrin M. Keiler, Sarah Baatout, Alexander Choukér, Jean-Pol Frippiat

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Alterations of the immune system could seriously impair the ability to combat infections during future long-duration space missions. However, little is known about the effects of spaceflight on the B-cell compartment. Given the limited access to astr

Externí odkaz: https://doaj.org/article/7b5e58cd47a6479995705ecf6fc97af0

Gravitational Experimental Platform for Animal Models, a New Platform at ESA’s Terrestrial Facilities to Study the Effects of Micro- and Hypergravity on Aquatic and Rodent Animal Models

Autor: Julie Bonnefoy, Stéphanie Ghislin, Jérôme Beyrend, Florence Coste, Gaetano Calcagno, Isabelle Lartaud, Guillemette Gauquelin-Koch, Sylvain Poussier, Jean-Pol Frippiat

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6, p 2961 (2021)

Using rotors to expose animals to different levels of hypergravity is an efficient means of understanding how altered gravity affects physiological functions, interactions between physiological systems and animal development. Furthermore, rotors can

Externí odkaz: https://doaj.org/article/0f9f0bacff4647b79d2f24d35a3f6bf8

Analysis of femurs from mice embarked on board BION‐M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on Earth

Autor: Blandine Chazarin, Nassima Ouzren-Zarhloul, Maude Gerbaix, Georg Tascher, Fabrice Bertile, Pauline Maes, Stéphanie Ghislin, Evgenia Antropova, Jean-Pol Frippiat, Galina Vassilieva, Laurence Vico, Guillemette Gauquelin-Koch

Publikováno v: FASEB Journal
FASEB Journal, 2019, 33 (3), pp.3772-3783. ⟨10.1096/fj.201801463R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (3), pp.3772-3783. ⟨10.1096/fj.201801463R⟩

Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronauts' health and safety. However, consequences on B-cell development and responses are still under-investigated. To fill this gap, we used advance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a43b785ed33c872a80c4f7b07c9bfc
https://doi.org/10.1096/fj.201801463r

Socioenvironmental stressors encountered during spaceflight partially affect the murine TCR‐β repertoire and increase its self‐reactivity

Autor: Laurence Lanfumey, Sandra Kaminski, Jean-Pol Frippiat, Charles Cohen-Salmon, Anne Vanet, Stéphanie Ghislin, Coralie Fonte

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (1), pp.896-908. ⟨10.1096/fj.201800969R⟩
FASEB Journal, 2019, 33 (1), pp.896-908. ⟨10.1096/fj.201800969R⟩

Spaceflights are known to affect the immune system. In a previous study, we demonstrated that hypergravity exposure during murine development modified 85% of the T-cell receptor (TCR)-β repertoire. In this study, we investigated whether socioenviron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc2b1304647f9792b4529b4b49bc297
https://doi.org/10.1096/fj.201800969r