Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Stéphanie Beaucourt"'
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Akademický článek
Mixed Infections Unravel Novel HCV Inter-Genotypic Recombinant Forms within the Conserved IRES Region
Autor: Natalia Echeverría, Fabiana Gámbaro, Stéphanie Beaucourt, Martín Soñora, Nelia Hernández, Juan Cristina, Gonzalo Moratorio, Pilar Moreno
Publikováno v: Viruses, Vol 16, Iss 4, p 560 (2024)
Hepatitis C virus (HCV) remains a significant global health challenge, affecting millions of people worldwide, with chronic infection a persistent threat. Despite the advent of direct-acting antivirals (DAAs), challenges in diagnosis and treatment re
Externí odkaz: https://doaj.org/article/e45035bacf0d42f9aaacf53da5d6d269
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2
Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases
Autor: Stéphanie Beaucourt, Colleen L. Watkins, Brian J. Kempf, David J. Barton, Olve B. Peersen
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (31), pp.10624-10637. ⟨10.1074/jbc.RA120.013906⟩
Journal of Biological Chemistry, 2020, 295 (31), pp.10624-10637. ⟨10.1074/jbc.RA120.013906⟩
J Biol Chem
International audience; Picornaviral RNA-dependent RNA polymerases (RdRPs) have low replication fidelity that is essential for viral fitness and evolution. Their global fold consists of the classical "cupped right hand" structure with palm, fingers,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3fad718547c0ef67fb1fe4dcfc91b0
https://hal-pasteur.archives-ouvertes.fr/pasteur-03216660
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3
Akademický článek
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.
Autor: Laura I Levi, Nina F Gnädig, Stéphanie Beaucourt, Malia J McPherson, Bruno Baron, Jamie J Arnold, Marco Vignuzzi
Publikováno v: PLoS Pathogens, Vol 6, Iss 10, p e1001163 (2010)
In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize that amiloride has a previously
Externí odkaz: https://doaj.org/article/b8763665235e41dca5c8d5331893504c
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4
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase
Autor: Mathy Froeyen, Leen Delang, Stéphanie Beaucourt, Bruno Canard, Ana Theresa Silveira de Morais, Isabelle Imbert, Johan Neyts, Marco Vignuzzi, Hervé Blanc, Pieter Leyssen, Rana Abdelnabi
Publikováno v: Journal of Virology
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ec8ca79e6936169943b98e6fae68ff
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928
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5
Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo
Autor: Marco Vignuzzi, Olve B. Peersen, Seth McDonald, Gonzalo Moratorio, Stéphanie Beaucourt, Andrew Block
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
COLIBRI
Universidad de la República
instacron:Universidad de la República
Journal of Biological Chemistry, 2016, 291 (27), pp.13999-14011. ⟨10.1074/jbc.M116.726596⟩
International audience; Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc79364b4ebc9b544b7b581079965a03
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545937
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6
Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases
Autor: Seth McDonald, Stéphanie Beaucourt, Grace Campagnola, Olve B. Peersen, Marco Vignuzzi
Publikováno v: Journal of Virology
Journal of Virology, 2015, 89 (1), pp.275-286. ⟨10.1128/JVI.01574-14⟩
Journal of Virology, American Society for Microbiology, 2015, 89 (1), pp.275-286. ⟨10.1128/JVI.01574-14⟩
Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b348407b013c131c7d5bc4edd90e8
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545941
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7
Molecular epidemiology of hepatitis C virus subtype 3a in injecting drug users
Autor: Robert G. Gish, Jean-François Cantaloube, Erwin Sablon, Michel Beaugrand, Daniel Dhumeaux, Sija De Gendt, Laetitia Barbotte, L. A. Butterworth, Fernando L. Gonçales, Regina Maria Bringel Martins, Fabian Fay, Oscar Fay, Jean-Michel Pawlotsky, Yoann Morice, Bart Vanderborght, Jorge E. González, Xavier de Lamballerie, Stéphanie Beaucourt, Graham Cooksley, Lieven Stuyver
Publikováno v: Journal of Medical Virology
Journal of Medical Virology, Wiley-Blackwell, 2006, 78, pp.1296-1303
International audience; Hepatitis C virus subtype 3a (HCV-3a) originates from Asia and has spread widely among injecting drug users as well as other patient groups in industrialized countries. HCV subtype 3a infection remains highly prevalent and fre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18635869082aec6d3a59c3a51d8d30c
https://doi.org/10.1002/jmv.20692
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8
Clinical utility of total HCV core antigen quantification: A new indirect marker of HCV replication
Autor: Gaston Picchio, Patrick Larderie, Jean-Michel Pawlotsky, Christophe Hézode, Harel Dahari, Lawrence M. Blatt, Daniel Dhumeaux, Keyur Patel, Magali Bouvier-Alias, Stéphanie Beaucourt, Avidan U. Neumann, John G. McHutchison
Publikováno v: Hepatology. 36:211-218
Hepatitis C virus (HCV) RNA detection, viral load quantification, and HCV genotyping are widely used in clinical practice. Recently, the availability of an anticore antigen (Ag) monoclonal antibody allowed development of an enzyme-linked immunosorben
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::309cfd458fb57acc47730ac8c634e563
https://doi.org/10.1053/jhep.2002.34130
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9
Ribavirin: a drug active against many viruses with multiple effects on virus replication and propagation. Molecular basis of ribavirin resistance
Autor: Marco Vignuzzi, Stéphanie Beaucourt
Publikováno v: Current Opinion in Virology
Current Opinion in Virology, Elsevier, 2014, 8, pp.10-15. ⟨10.1016/j.coviro.2014.04.011⟩
Current Opinion in Virology, 2014, 8, pp.10-15. ⟨10.1016/j.coviro.2014.04.011⟩
Highlights • A broad spectrum antiviral effective against virtually all viruses tested in vitro. • Mechanism of action varies with virus and cell type. • Virus resistance often involves increase in replication fidelity. • Cell host resistance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90edbb53fefe39947878863f2199bebd
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545948
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10
Coxsackievirus B3 mutator strains are attenuated in vivo
Autor: Hervé Blanc, Stéphanie Beaucourt, Nina F. Gnädig, Grace Campagnola, Antonio V. Bordería, Marta Sanz-Ramos, Peng Gong, Olve B. Peersen, Marco Vignuzzi
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (34), pp.E2294-303. ⟨10.1073/pnas.1204022109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (34), pp.E2294-303. ⟨10.1073/pnas.1204022109⟩
Proceedings of the National Academy of Sciences
International audience; Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb7ef443aaf1be4e0ca56a44ca13595
https://hal-pasteur.archives-ouvertes.fr/pasteur-00918212
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