Výsledky vyhledávání - "Stéphanie, Vougier"

Akademický článek

AI4DR: Development and implementation of an annotation system for high-throughput dose-response experiments

Autor: Marc Bianciotto, Lionel Colliandre, Kun Mi, Isabelle Schreiber, Cécile Delorme, Stéphanie Vougier, Hervé Minoux

Publikováno v: Artificial Intelligence in the Life Sciences, Vol 3, Iss , Pp 100063- (2023)

One of the common strategies to identify novel chemical matter in drug discovery consists in performing a High Throughput Screening (HTS). However, the large amount of data generated at the dose-response (DR) step of an HTS campaign requires a carefu

Externí odkaz: https://doaj.org/article/4b1eeeb21d1d47e49e0b39e46a0c147d

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Integration of protein kinases into transcription complexes: identifying components of immobilised in vitro pre-initiation complexes

Autor: Hong-Mei, Zhang, Stéphanie, Vougier, Glenn, Hodgson, Peter E, Shaw

Publikováno v: Methods in molecular biology (Clifton, N.J.). 647

Regulation of gene expression is essential for coordinated cell growth and development. The de-regulation of certain genes is also recognised to contribute to both heritable and acquired disease. Transcription factors influence the assembly and activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::867978902d9f06ae760bcb314a20473e
https://pubmed.ncbi.nlm.nih.gov/20694675

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Enzymatic reactions involved in the repair of oxidized proteins

Autor: Isabelle Petropoulos, Jean Yves Mary, Stéphanie Vougier, Bertrand Friguet, Martine Perichon, Cédric R. Picot

Publikováno v: Experimental gerontology. 39(8)

Proteins are the targets of reactive oxygen species, and cell aging is characterized by a build-up of oxidized proteins. Oxidized proteins tend to accumulate with age, due to either an increase in the rate of protein oxidation, a decrease in the rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c802a80dd83007a293b45ab6cabd069
https://pubmed.ncbi.nlm.nih.gov/15359468

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Essential Role of Methionine Residues in Calmodulin Binding to Bordetella pertussis Adenylate Cyclase, as Probed by Selective Oxidation and Repair by the Peptide Methionine Sulfoxide Reductases

Autor: Daniel Ladant, Nathalie Dautin, Stéphanie Vougier, Jean Yves Mary, Joëlle Vinh, Bertrand Friguet

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (29), pp.30210-30218. ⟨10.1074/jbc.M400604200⟩
Journal of Biological Chemistry, 2004, 279 (29), pp.30210-30218. ⟨10.1074/jbc.M400604200⟩

International audience; Bordetella pertussis, the causative agent of whooping cough, secretes among other virulence factors an adenylate cyclase (AC) toxin that is able to enter into eukaryotic cells where it is activated upon binding to endogenous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0172afad51831c905684fcd0736f0ea6
https://hal.archives-ouvertes.fr/hal-01636955

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Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells

Autor: Bertrand Friguet, Stéphanie Vougier, Jean Yves Mary

Proteins are sensitive to reactive oxygen species, and the accumulation of oxidized proteins has been implicated in the aging process and in other age-related pathologies. In proteins, methionine residues are especially sensitive to oxidation, leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8646c8271e44e9c2cd4e784b2dbc725e
https://europepmc.org/articles/PMC1223498/

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