Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stéphanie, Tardif"'
Publikováno v:
European Journal of Pharmacology. 669:51-58
N-desmethylclozapine (NDMC or norclozapine) is the major active metabolite of the antipsychotic clozapine in humans. The activity of NDMC differs from clozapine at a number of neurotransmitter receptors, probably influencing the pharmacological effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7390587887ae1e905c24b0d2a063dbdf
https://doi.org/10.1016/j.ejphar.2011.07.031
https://doi.org/10.1016/j.ejphar.2011.07.031
Publikováno v:
Journal of receptor and signal transduction research. 36(2)
The appearance of "bell"- (or "inverted U"-) shaped agonist concentration-response curves (CRCs) in in vitro pharmacological experiments is a frequently observed but poorly communicated phenomenon. In the context of G protein coupled receptor researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b611256d993f826ba3904bf428368e93
https://pubmed.ncbi.nlm.nih.gov/26466637
https://pubmed.ncbi.nlm.nih.gov/26466637
Autor:
Stéphanie Tardif, Amélie Tourette, David Troulier, Antoine Dumoulin, Marie‐Thérèse Calmettes, Delphine Denais-Lalieve, Marie-Christine Ailhaud, Claudie Cathala, Luc De Vries, Isabelle Rauly-Lestienne, Anne-Dominique Degryse, Emilie Lauressergues, Didier Cussac, Fabrice Lestienne, Peter Heusler
Publikováno v:
Pharmacology Research & Perspectives
The Hedgehog (HH) pathway has been linked to the formation of basal cell carcinoma (BCC), medulloblastoma, and other cancers. The recently approved orally active drugs vismodegib (GDC‐0449) and sonidegib (LDE–225) were not only efficacious for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58dcc34913644c8ac672599699b2397
https://pubmed.ncbi.nlm.nih.gov/27069629
https://pubmed.ncbi.nlm.nih.gov/27069629
Autor:
Emmanuel Naline, Peter Heusler, Thierry Clerc, Didier Cussac, Stéphanie Tardif, Philippe Devillier
Publikováno v:
Pharmacological research. 100
The anticholinergic properties of the mequitazine enantiomer V0162 make it a drug candidate for the treatment of chronic obstructive airway diseases. Here, we compared V0162’s in vitro pharmacological activity at recombinant human M 3 muscarinic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c8f9911abf9163ba67d5b34ac77312
https://pubmed.ncbi.nlm.nih.gov/26241178
https://pubmed.ncbi.nlm.nih.gov/26241178
Autor:
Stéphanie Tardif, Petrus J. Pauwels
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 366:134-141
The hypothesis that prolonged treatment of a constitutively active receptor with inverse agonists may lead to increased receptor density was tested for the alpha(2)-adrenoceptor (AR) inverse agonist (+)-RX 811059 at both the wild-type (WT) and Thr(37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21ac3cc5612be1a9af1cf0043037182
https://doi.org/10.1007/s00210-002-0562-x
https://doi.org/10.1007/s00210-002-0562-x
Publikováno v:
Biochemical Pharmacology. 62:723-732
G-protein activation and Ca 2+ responses by the wild-type D 2short receptor and a mutation Thr 343 Arg, in the distal BBX X B motif of its third intracellular loop, were investigated in CHO-K1 cells in terms of ligand:receptor:G-protein interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5df064b3aa822a81d0c4d4151312436
https://doi.org/10.1016/s0006-2952(01)00717-1
https://doi.org/10.1016/s0006-2952(01)00717-1
Publikováno v:
British Journal of Pharmacology. 134:88-97
Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4444e0b3ccfc12828f6af624d936e7b3
https://doi.org/10.1038/sj.bjp.0704243
https://doi.org/10.1038/sj.bjp.0704243
Publikováno v:
Neuropharmacology. 38:1035-1041
The activity state of G proteins is involved in the ligands' maximal responses that can be produced by activating the 5-HT1A receptor (Pauwels et al., 1997). The present study investigated the ligand responses at the recombinant h 5-HT1A receptor (RC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bbac13914644124947a04ebaaa3984
https://doi.org/10.1016/s0028-3908(99)00033-7
https://doi.org/10.1016/s0028-3908(99)00033-7
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 356:551-561
G-protein activation by different 5-HT receptor ligands was investigated in h5-HT1A receptor-transfected C6-glial and HeLa cells using agonist-stimulated [35S]GTPγS binding to membranes in the presence of excess GDP. 5-HT (10 μM) stimulated [35S]GT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e4c361dbc6e41887f0ce9e77e9e49a
https://doi.org/10.1007/pl00005090
https://doi.org/10.1007/pl00005090
Publikováno v:
European journal of pharmacology. 669(1-3)
N-desmethylclozapine (NDMC or norclozapine) is the major active metabolite of the antipsychotic clozapine in humans. The activity of NDMC differs from clozapine at a number of neurotransmitter receptors, probably influencing the pharmacological effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4082ae967fc0b337c7c344dee7cc132f
https://pubmed.ncbi.nlm.nih.gov/21835172
https://pubmed.ncbi.nlm.nih.gov/21835172