The Bicyclic Form of

Autor: Agnete, Viuff, Stéphane, Salamone, Joseph, McLoughlin, Janet E, Deane, Henrik H, Jensen

Publikováno v: ACS Med Chem Lett

[Image: see text] Competitive inhibitors of galactocerebrosidase (GALC) could be candidates for pharmacological chaperone therapy of patients with Krabbe disease. The known and selective nortropane-type iminosugar galacto-noeurostegine has been found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3625c7dd73b5783d2fa059dc06295126
https://pubmed.ncbi.nlm.nih.gov/33488964

Azasugar inhibitors as pharmacological chaperones for Krabbe disease

Autor: Janet E. Deane, Stig H. Christensen, Randy J. Read, Samantha J. Spratley, Nigel W. Moriarty, Chris H. Hill, Agnete H. Viuff, Henrik H. Jensen, Stéphane Salamone

Publikováno v: Chemical Science

Modified azasugar molecules have been synthesized and characterized as excellent pharmacological chaperone candidates to treat the neurodegenerative disorder Krabbe disease.
Krabbe disease is a devastating neurodegenerative disorder characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051f3f4ab60ed240ba330e828ff0f3d
https://doi.org/10.1039/c5sc00754b

New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines

Autor: Stéphane Flament, Julie Lecomte, Christelle Colin, Sandra Kuntz, Michel Boisbrun, Stéphane Salamone, Isabelle Grillier-Vuissoz, Yves Chapleur

Publikováno v: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2010, 124 (1), pp.101-110. ⟨10.1007/s10549-009-0700-y⟩

International audience; Numerous recent studies indicate that most anticancer effects of PPARγ agonists like thiazolidinediones are the result of PPARγ-independent pathways. These conclusions were obtained by several approaches including the use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbe84f368d892451c315923e4a7b4ee
https://doi.org/10.1007/s10549-009-0700-y

Synthesis and evaluation of galacto-noeurostegine and its 2-deoxy analogue as glycosidase inhibitors

Autor: Ole Juul Andersen, Stéphane Salamone, Frank Jensen, Henrik H. Jensen, Lise L. Clement, Agnete H. Viuff

Publikováno v: Salamone, S, Clement, L L, Viuff, A H, Andersen, O J, Jensen, F & Jensen, H H 2015, ' Synthesis and evaluation of galacto-noeurostegine and its 2-deoxy analogue as glycosidase inhibitors ', Organic & Biomolecular Chemistry, vol. 13, no. 29, pp. 7979-7992 . https://doi.org/10.1039/c5ob01062d

An epimer of the known glycosidase inhibitor noeurostegine, galacto-noeurostegine, was synthesised in 21 steps from levoglucosan and found to be a potent, competitive and highly selective galactosidase inhibitor of Aspergillus oryzae β-galactosidase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa3cf5280999e76ef6669a5c86e98ea
https://pure.au.dk/portal/da/publications/synthesis-and-evaluation-of-galactonoeurostegine-and-its-2deoxy-analogue-as-glycosidase-inhibitors(fed116d8-cff6-4b7a-88e1-38b7ce3b3336).html

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

Autor: Isabelle André, Laurence A. Mulard, Emmanuelle Cambon, Magali Remaud-Simeon, Catherine Guerreiro, Stéphane Salamone

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2015, 51 (13), pp.2581-2584. ⟨10.1039/c4cc08805k⟩
Chemical Communications, 2015, 51 (13), pp.2581-2584. ⟨10.1039/c4cc08805k⟩

The powerful chemo-enzymatic synthesis of the pentadecasaccharide hapten involved in the first synthetic carbohydrate-based vaccine candidate against endemic shigellosis is reported. The high yielding site-selective alpha-D-glucosylation of a lightly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb6b078fe28ad02c619b1db457191fb
https://hal.archives-ouvertes.fr/hal-01269073