Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Stéphane P. Roche"'
Autor:
Stéphane P. Roche
Publikováno v:
Organics, Vol 2, Iss 4, Pp 376-387 (2021)
The stunning advances in understanding the reactivity and selectivity principles of asymmetric pericyclic reactions have had a profound impact on the synthetic planning of complex natural products. Indeed, electrocyclizations, cycloadditions, and sig
Externí odkaz:
https://doaj.org/article/e34854fd418c4d278e7e33db49186a17
Autor:
Jillene Moxam, Sarah Naylon, Alexis D. Richaud, Guangkuan Zhao, Alberto Padilla, Stéphane P. Roche
Publikováno v:
ACS Medicinal Chemistry Letters. 14:278-284
Publikováno v:
J Org Chem
Despite their pivotal role in defining antibody affinity and protein function, β-hairpins harboring long noncanonical loops remain synthetically challenging because of the large entropic penalty associated with their conformational folding. Little i
Autor:
Alexis D. Richaud, Mehdi Zaghouani, Guangkuan Zhao, Medhi Wangpaichitr, Niramol Savaraj, Stéphane P. Roche
Publikováno v:
ChemBioChem. 23
Checkpoint blockade of the immunoreceptor programmed cell death-1 (PD1) with its ligand-1 (PDL1) by monoclonal antibodies such as pembrolizumab provided compelling clinical results in various cancer types, yet the molecular mechanism by which this dr
Autor:
Stéphane P. Roche, Shyam S. Samanta
Publikováno v:
European Journal of Organic Chemistry. 2019:6597-6605
A general and efficient synthesis of α-haloglycine esters from commercially available feedstock chemicals, in a single step, is reported. The reactivity of these α-haloglycine esters with various nucleophiles was studied as surrogates of α-iminoes
Publikováno v:
J Am Chem Soc
We report a chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible α-chloro glyci
Checkpoint blockade of the Programmed cell Death-1 (PD-1) immunoreceptor with its ligand 1 (PD-L1) by the monoclonal antibody pembrolizumab provided compelling clinical results among various cancer types, yet the molecular mechanism by which this dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c12f84f66628dcd4675f925254f131
https://doi.org/10.26434/chemrxiv.14477730.v1
https://doi.org/10.26434/chemrxiv.14477730.v1
Macrocyclic furanobutenolide-derived cembranoids (FBCs) are the biosynthetic precursors to a wide variety of highly congested and oxygenated polycyclic (nor)diterpenes (e.g. plumarellide, verrillin, and bielschowskysin). These architecturally complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f82dbec7559c819be9290b219101fe
https://doi.org/10.26434/chemrxiv.13377173.v1
https://doi.org/10.26434/chemrxiv.13377173.v1
Autor:
Alexis D. Richaud, Stéphane P. Roche
Publikováno v:
J Org Chem
The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a short b-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6fb1f2a80337f3e8e619fc00415dec
https://europepmc.org/articles/PMC7659681/
https://europepmc.org/articles/PMC7659681/
Publikováno v:
Org Lett
A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an