Zobrazeno 1 - 10 of 426 pro vyhledávání: '"Stéphane Mandard"'
1
Akademický článek
Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation
Autor: Ali Tawbeh, Quentin Raas, Mounia Tahri-Joutey, Céline Keime, Romain Kaiser, Doriane Trompier, Boubker Nasser, Emma Bellanger, Marie Dessard, Yannick Hamon, Alexandre Benani, Francesca Di Cara, Tânia Cunha Alves, Johannes Berger, Isabelle Weinhofer, Stéphane Mandard, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Catherine Gondcaille, Stéphane Savary
Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)
Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked adrenoleukodystrophy (X-ALD), a neuroinflammatory disorder, very long-
Externí odkaz: https://doaj.org/article/911be27ef95548c485aa7100b731715f
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2
Akademický článek
Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice
Autor: Aloïs Dusuel, Valérie Deckert, Jean-Paul Pais de Barros, Kevin van Dongen, Hélène Choubley, Émilie Charron, Naig Le Guern, Jérôme Labbé, Stéphane Mandard, Jacques Grober, Laurent Lagrost, Thomas Gautier
Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100011- (2021)
Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflammatory cascade or LPS bin
Externí odkaz: https://doaj.org/article/44bb1260f336492c90708a2cd50fdd02
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3
Akademický článek
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion
Autor: Lorène J. Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H.C. Dejong, Matthijs Kox, Inca H.R. Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J. Drucker, Laurent Lagrost, Jacques Grober
Publikováno v: Cell Reports, Vol 21, Iss 5, Pp 1160-1168 (2017)
Summary: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that
Externí odkaz: https://doaj.org/article/54c442ddf2554e8d93b3af382d5f41cd
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4
Akademický článek
Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids
Autor: Aafke W.F. Janssen, Tom Houben, Saeed Katiraei, Wieneke Dijk, Lily Boutens, Nieke van der Bolt, Zeneng Wang, J. Mark Brown, Stanley L. Hazen, Stéphane Mandard, Ronit Shiri-Sverdlov, Folkert Kuipers, Ko Willems van Dijk, Jacques Vervoort, Rinke Stienstra, Guido J.E.J. Hooiveld, Sander Kersten
Publikováno v: Journal of Lipid Research, Vol 58, Iss 7, Pp 1399-1416 (2017)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding m
Externí odkaz: https://doaj.org/article/2286f7d2573e4f138729a349daad9513
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5
Akademický článek
Antibody Treatment against Angiopoietin-Like 4 Reduces Pulmonary Edema and Injury in Secondary Pneumococcal Pneumonia
Autor: Liang Li, Benjamin Jie Wei Foo, Ka Wai Kwok, Noriho Sakamoto, Hiroshi Mukae, Koichi Izumikawa, Stéphane Mandard, Jean-Pierre Quenot, Laurent Lagrost, Wooi Keong Teh, Gurjeet Singh Kohli, Pengcheng Zhu, Hyungwon Choi, Martin Lindsay Buist, Ju Ee Seet, Liang Yang, Fang He, Vincent Tak Kwong Chow, Nguan Soon Tan
Publikováno v: mBio, Vol 10, Iss 3 (2019)
ABSTRACT Secondary bacterial lung infection by Streptococcus pneumoniae (S. pneumoniae) poses a serious health concern, especially in developing countries. We posit that the emergence of multiantibiotic-resistant strains will jeopardize current treat
Externí odkaz: https://doaj.org/article/1bf0767f133a40f4a35769c99d508b56
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6
Akademický článek
Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides
Autor: Fatima-Ezzahra Saih, Pierre Andreoletti, Stéphane Mandard, Norbert Latruffe, M’Hammed Saïd El Kebbaj, Gérard Lizard, Boubker Nasser, Mustapha Cherkaoui-Malki
Publikováno v: Molecules, Vol 22, Iss 1, p 102 (2017)
In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of Opuntia ficus-indica cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS
Externí odkaz: https://doaj.org/article/9d2f5adb166741c8b6577c75d889f462
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7
Akademický článek
Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors
Autor: Stéphane Mandard, David Patsouris
Publikováno v: PPAR Research, Vol 2013 (2013)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that play pivotal roles in the regulation of a very large number of biological processes including inflammation. Using specific examples, this paper focuse
Externí odkaz: https://doaj.org/article/56e2b65a32834e84a4a0738a986e1840
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9
Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis
Autor: Danish, Patoli, Franck, Mignotte, Valérie, Deckert, Alois, Dusuel, Adélie, Dumont, Aurélie, Rieu, Antoine, Jalil, Kevin, Van Dongen, Thibaut, Bourgeois, Thomas, Gautier, Charlène, Magnani, Naig, Le Guern, Stéphane, Mandard, Jean, Bastin, Fatima, Djouadi, Christine, Schaeffer, Nina, Guillaumot, Michel, Narce, Maxime, Nguyen, Julien, Guy, Auguste, Dargent, Jean-Pierre, Quenot, Mickaël, Rialland, David, Masson, Johan, Auwerx, Laurent, Lagrost, Charles, Thomas
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2020, 130996, Online ahead of print. ⟨10.1172/JCI130996⟩
Journal of Clinical Investigation, 2020, 130996, Online ahead of print. ⟨10.1172/JCI130996⟩
J Clin Invest
International audience; Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis but its contribution to macrophage functions and host defense remains to be delineated. Here we showed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6d51b08d85cf60fc9a121f9576d08480
https://www.hal.inserm.fr/inserm-02926629
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10
Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice
Autor: Thomas Gautier, Kevin van Dongen, Émilie Charron, Stéphane Mandard, Valérie Deckert, Jean-Paul Pais de Barros, Hélène Choubley, Jérôme Labbé, Naig Le Guern, Jacques Grober, Alois Dusuel, Laurent Lagrost
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100011-(2021)
Journal of Lipid Research, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩
International audience; Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflamm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd34527c453da1363375ba2659935a9
https://www.hal.inserm.fr/inserm-03052637
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