Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stéphane Lopes-Paciencia"'
Autor:
Stéphane Lopes-Paciencia, Véronique Bourdeau, Marie-Camille Rowell, Davoud Amirimehr, Jordan Guillon, Paloma Kalegari, Arnab Barua, Vincent Quoc-Huy Trinh, Feryel Azzi, Simon Turcotte, Adrian Serohijos, Gerardo Ferbeyre
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114044- (2024)
Summary: We identify a senescence restriction point (SeRP) as a critical event for cells to commit to senescence. The SeRP integrates the intensity and duration of oncogenic stress, keeps a memory of previous stresses, and combines oncogenic signals
Externí odkaz:
https://doaj.org/article/991cc27b36934f9e9ca9610edd8935ba
Autor:
Gerardo Ferbeyre, Paloma Kalegari, Lian Mignacca, Frédéric Lessard, Jan Pencik, Geneviève Huot, Jordan Quenneville, Marie-Camille Rowell, Laura Hulea, Jacob Bouchard, Stéphane Lopes-Paciencia, Michael Pollak, Oro Uchenunu, Ana Fernandez-Ruiz, Katja Julissa Ponce, Etienne Gagnon, Nhung Vuong, Véronique Bourdeau, Mehdi Benfdil, Haytham M. Wahba, Ivan Topisitrovic, James G. Omichinski, Richard Moriggl, Antonio Nanci, Sebastian Igelmann, Aurélien Fouillen, David Papadopoli, Lukas Kenner
Publikováno v:
SSRN Electronic Journal.
Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a novel multi-enzymatic complex that reprograms NAD metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ba7a35c7f68a80a84e12eade3c594f
https://doi.org/10.2139/ssrn.3753808
https://doi.org/10.2139/ssrn.3753808
Autor:
Alexios N. Matralis, Geneviève Huot, Hugo de Vries, Stéphane Lopes-Paciencia, Youla S. Tsantrizos, Charles Cole, Dimitrios Xanthopoulos, Gerardo Ferbeyre
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:5547-5554
Lamin A contributes to the structure of nuclei in all mammalian cells and plays an important role in cell division and migration. Mature lamin A is derived from a farnesylated precursor protein, known as prelamin A, which undergoes post-translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c3de7bb9701b8a4e3fd82b3351296a
https://doi.org/10.1016/j.bmc.2018.10.001
https://doi.org/10.1016/j.bmc.2018.10.001
Autor:
Xavier Deschênes-Simard, Marlene Oeffinger, Cornelia E. Zorca, Sebastian Igelmann, Léa Brakier-Gingras, Daniel Zenklusen, Emmanuelle Saint-Germain, Olga Moiseeva, Geneviève Huot, Neylen Del Toro, Lian Mignacca, Benjamin Le Calvé, Marinieve Montero, Marie-Camille Rowell, Frédéric Lessard, Véronique Bourdeau, Gerardo Ferbeyre, Christian Trahan, Marina Bury, Stéphane Lopes-Paciencia
Publikováno v:
Nature Cell Biology. 20:789-799
Cellular senescence is a tumour suppressor programme characterized by a stable cell cycle arrest. Here we report that cellular senescence triggered by a variety of stimuli leads to diminished ribosome biogenesis and the accumulation of both rRNA prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73568848198ad7a458ebe043b524f17e
https://doi.org/10.1038/s41556-018-0127-y
https://doi.org/10.1038/s41556-018-0127-y
Autor:
Oro Uchenunu, Gerardo Ferbeyre, James G. Omichinski, Paloma Kalegari, David Papadopoli, Antonio Nanci, Ivan Topisirovic, Jordan Quenneville, Sebastian Igelmann, Laura Hulea, Aurélien Fouillen, Lukas Kenner, Jordan Guillon, Véronique Bourdeau, Haytham M. Wahba, Jacob Bouchard, Etienne Gagnon, Richard Moriggl, Mehdi Benfdil, Jan Pencik, Marie-Camille Rowell, Katia Julissa Ponce, Frédéric Lessard, Lian Mignacca, Stéphane Lopes-Paciencia, Michael Pollak, Ana Fernandez-Ruiz, Geneviève Huot, Nhung Vuong
Publikováno v:
Molecular Cell. 81:3848-3865.e19
Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex that reprograms NAD metabolism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd9ac33bfd391617e3ed4d32b35759f
https://doi.org/10.1016/j.molcel.2021.08.028
https://doi.org/10.1016/j.molcel.2021.08.028
Autor:
Gerardo Ferbeyre, Paloma Kalegari, Léa Brakier-Gingras, Emmanuelle Saint-Germain, Sebastian Igelmann, Mehdi Benfdil, Lian Mignacca, Véronique Bourdeau, Marie-Camille Rowell, Neylen Del Toro, Ana Fernandez-Ruiz, Frédéric Lessard, Stéphane Lopes-Paciencia
Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba23de22e1eda67ba431f1b1cd846602
https://europepmc.org/articles/PMC6464582/
https://europepmc.org/articles/PMC6464582/
Publikováno v:
Aging (Albany NY)
Mutants of lamin A cause diseases including the Hutchinson-Gilford progeria syndrome (HGPS) characterized by premature aging. Lamin A undergoes a series of processing reactions, including farnesylation and proteolytic cleavage of the farnesylated C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d4f85412c9f8058a3ec46b24d24eaa
http://europepmc.org/articles/PMC4789588
http://europepmc.org/articles/PMC4789588
Autor:
Gerardo Ferbeyre, Frédéric Lamoliatte, Mariana Acevedo, Lian Mignacca, Francis P. McManus, Pierre Thibault, Véronique Bourdeau, Stéphane Lopes-Paciencia, John W. Rojas Pino
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Several regulators of SUMOylation have been previously linked to senescence but most targets of this modification in senescent cells remain unidentified. Using a two-step purification of a modified SUMO3, we profiled the SUMO proteome of senescent ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ea8d5f0dab8c915dd85b1c57c18550
http://europepmc.org/articles/PMC5958138
http://europepmc.org/articles/PMC5958138
Autor:
Bernhard Lehnertz, Stéphane Lopes-Paciencia, Nadine Mayotte, Romain Aucagne, Jalila Chagraoui, Geneviève Boucher, Patrick Gendron, Guy Sauvageau, Simon Girard
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (11), pp.5012-5018. 〈http://www.fasebj.org/content/31/11/5012.short〉. 〈10.1096/fj.201601219RRR〉
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (11), pp.5012-5018. ⟨10.1096/fj.201601219RRR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (11), pp.5012-5018. 〈http://www.fasebj.org/content/31/11/5012.short〉. 〈10.1096/fj.201601219RRR〉
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (11), pp.5012-5018. ⟨10.1096/fj.201601219RRR⟩
International audience; The ubiquitin-associated protein 2-like (UBAP2L) gene remains poorly studied in human and mouse development. UBAP2L interacts with the Polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and determines t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3e04193b961b8d98038c1c1922058
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01680746
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01680746
Autor:
Ana Fernandez Ruiz, Filippos Kottakis, Benjamin Le Calvé, Stéphane Lopes-Paciencia, Nabeel Bardeesy, Xavier Deschênes-Simard, Marie-Camille Rowell, Gerardo Ferbeyre
Publikováno v:
Cancer Research. 78:462-462
This study aims to better understand the loss of tumor -uppression functions of ERK in pancreatic cancer progression. Pancreatic cancer is the 4th leading cause of death by cancer in Canada and USA with a 5-year survival rate below 7%. We have identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e5d80dd2ba655ca2b82e0e7f8765962
https://doi.org/10.1158/1538-7445.am2018-462
https://doi.org/10.1158/1538-7445.am2018-462