Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stéphane Koundrioukoff"'
Autor:
Olivier Brison, Sami El-Hilali, Dana Azar, Stéphane Koundrioukoff, Mélanie Schmidt, Viola Nähse, Yan Jaszczyszyn, Anne-Marie Lachages, Bernard Dutrillaux, Claude Thermes, Michelle Debatisse, Chun-Long Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Common Fragile Sites (CFSs) are chromosome regions prone to breakage upon replication stress known to drive chromosome rearrangements during oncogenesis. Here the authors use genome-wide and single cell techniques to assess how replication timing and
Externí odkaz:
https://doaj.org/article/faa892657e9143c2a1486f882b9f0db1
Autor:
Hervé Técher, Stéphane Koundrioukoff, Sandra Carignon, Therese Wilhelm, Gaël A. Millot, Bernard S. Lopez, Olivier Brison, Michelle Debatisse
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1114-1127 (2016)
Summary: Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have remained unclear. We show that exogenous deoxyribonucleosides suppress both replication p
Externí odkaz:
https://doaj.org/article/3948f05e96414462b215d0227997ff4b
Autor:
Benoit Miotto, Moredreck Chibi, Ping Xie, Stéphane Koundrioukoff, Hanlie Moolman-Smook, David Pugh, Michelle Debatisse, Fuchu He, Lingqiang Zhang, Pierre-Antoine Defossez
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 575-587 (2014)
Summary: Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete genome replication leads to DNA breaks and chromosomal rearrangements, which are causal factors in cancer and other human diseases. Despite their impor
Externí odkaz:
https://doaj.org/article/f4d98e21d46c47f69fdb4ef660128230
Autor:
Stéphane Koundrioukoff, Sandra Carignon, Hervé Técher, Anne Letessier, Olivier Brison, Michelle Debatisse
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003643 (2013)
Breaks at common fragile sites (CFS) are a recognized source of genome instability in pre-neoplastic lesions, but how such checkpoint-proficient cells escape surveillance and continue cycling is unknown. Here we show, in lymphocytes and fibroblasts,
Externí odkaz:
https://doaj.org/article/d484528a1312455ea70ca5c9b00c4e0a
Autor:
Olivier Brison, Stefano Gnan, Dana Azar, Stéphane Koundrioukoff, Rodrigo Melendez-Garcia, Su-Jung Kim, Mélanie Schmidt, Sami El-Hilali, Yan Jaszczyszyn, Anne-Marie Lachages, Claude Thermes, Chun-Long Chen, Michelle Debatisse
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2023
Nature Structural and Molecular Biology, 2023
International audience; Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this coordination by inhibiting CDK1, which delays mitotic onset. Under-replication of Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decdf956c27dcb59f8e2922bec790aab
https://doi.org/10.1038/s41594-023-00949-1
https://doi.org/10.1038/s41594-023-00949-1
Autor:
Cadoret, Su-Jung Kim, Chrystelle Maric, Lina-Marie Briu, Fabien Fauchereau, Giuseppe Baldacci, Michelle Debatisse, Stéphane Koundrioukoff, Jean-Charles
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10629
Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce cell cycle arrest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::376575cb2c78e74f20a1c249c23b1e3f
Autor:
Fabio Hecht, Laura Valerio, Carlos Frederico Lima Gonçalves, Marylin Harinquet, Rabii Ameziane El Hassani, Denise P Carvalho, Stephane Koundrioukoff, Jean-Charles Cadoret, Corinne Dupuy
Publikováno v:
European Thyroid Journal, Vol 13, Iss 4, Pp 1-9 (2024)
Objective: Ionizing radiation generates genomic instability by promoting the accumulation of chromosomal rearrangements. The oncogenic translocation RET/PTC1 is present in more than 70% of radiation-induced thyroid cancers. Both RET and CCDC6, the ge
Externí odkaz:
https://doaj.org/article/3f7d45cd41f1485cb517d7dde280a482
Autor:
Elie Saliba, Stéphane Koundrioukoff, Gordon C. Tucker, David Gentien, Leanne De Koning, Sergio Roman-Roman, Thierry Dubois, Stéphane Depil, Didier Meseure, Didier Decaudin, André Nicolas, Mengliang Ye, Michelle Debatisse, Guillem Rigaill, Amélie Brisson, Alain Pierré, Francisco Cruzalegui, Bruno Tesson, Céline Baldeyron, Fariba Nemati, Elise Martel
Publikováno v:
Molecular Oncology
Molecular Oncology, Elsevier, 2015, 9 (8), pp.1580-1598. ⟨10.1016/j.molonc.2015.04.010⟩
Molecular Oncology, 2015, 9 (8), pp.1580-1598. ⟨10.1016/j.molonc.2015.04.010⟩
Molecular Oncology, Elsevier, 2015, 9 (8), pp.1580-1598. ⟨10.1016/j.molonc.2015.04.010⟩
Molecular Oncology, 2015, 9 (8), pp.1580-1598. ⟨10.1016/j.molonc.2015.04.010⟩
International audience; Triple-negative breast cancer (TNBC) is the breast cancer subgroup with the most aggressive clinical behavior. Alternatives to conventional chemotherapy are required to improve the survival of TNBC patients. Gene-expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c13b5aa19440d325d4b3761f7d44e3
https://doi.org/10.1016/j.molonc.2015.04.010
https://doi.org/10.1016/j.molonc.2015.04.010
Autor:
Therese Wilhelm, Olivier Brison, Bernard S. Lopez, Gaël A. Millot, Stéphane Koundrioukoff, Hervé Técher, Michelle Debatisse, Sandra Carignon
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2016, 14 (5), pp. 1114-1127. ⟨10.1016/j.celrep.2015.12.093⟩
Cell Reports, Vol 14, Iss 5, Pp 1114-1127 (2016)
Cell Reports, 2016, 14 (5), pp. 1114-1127. ⟨10.1016/j.celrep.2015.12.093⟩
Cell Reports, Elsevier Inc, 2016, 14 (5), pp. 1114-1127. ⟨10.1016/j.celrep.2015.12.093⟩
Cell Reports, Vol 14, Iss 5, Pp 1114-1127 (2016)
Cell Reports, 2016, 14 (5), pp. 1114-1127. ⟨10.1016/j.celrep.2015.12.093⟩
Summary: Mammalian cells deficient in ATR or Chk1 display moderate replication fork slowing and increased initiation density, but the underlying mechanisms have remained unclear. We show that exogenous deoxyribonucleosides suppress both replication p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d192d627b0f53e452cd6c632720d7f8
https://hal.sorbonne-universite.fr/hal-01284494
https://hal.sorbonne-universite.fr/hal-01284494
Autor:
Stéphane Koundrioukoff, Michelle Debatisse, Marcus B. Smolka, S Hernández-Pérez, Elisa Cabrera, David A. Gillespie, Raimundo Freire, Dongsung Kim
Publikováno v:
Oncogene. 36(5)
Stresses such as hypoxia, nutrient deprivation and acidification disturb protein folding in the endoplasmic reticulum (ER) and activate the Unfolded Protein Response (UPR) to trigger adaptive responses through the effectors, PERK, IRE1 and ATF6. Most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a9b485c74a040c0565b4e16c41222
https://pubmed.ncbi.nlm.nih.gov/27375025
https://pubmed.ncbi.nlm.nih.gov/27375025