Autophagy compensates for defects in mitochondrial dynamics.

Autor: Simon Haeussler, Fabian Köhler, Michael Witting, Madeleine F Premm, Stéphane G Rolland, Christian Fischer, Laetitia Chauve, Olivia Casanueva, Barbara Conradt

Publikováno v: PLoS Genetics, Vol 16, Iss 3, p e1008638 (2020)

Compromising mitochondrial fusion or fission disrupts cellular homeostasis; however, the underlying mechanism(s) are not fully understood. The loss of C. elegans fzo-1MFN results in mitochondrial fragmentation, decreased mitochondrial membrane potent

Externí odkaz: https://doaj.org/article/5eb7912696fe4e9a82e7cd058c0493d6

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

Autor: Stéphane G. Rolland, Sandra Schneid, Melanie Schwarz, Elisabeth Rackles, Christian Fischer, Simon Haeussler, Saroj G. Regmi, Assa Yeroslaviz, Bianca Habermann, Dejana Mokranjac, Eric Lambie, Barbara Conradt

Publikováno v: Cell Reports, Vol 28, Iss 7, Pp 1659-1669.e5 (2019)

Summary: The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C. elegans genome and identified 171 genes that, w

Externí odkaz: https://doaj.org/article/bb9e8700709048ba97d48a57f558b8ab

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

Autor: Barbara Conradt, Christian Fischer, Assa Yeroslaviz, Elisabeth Rackles, Saroj G. Regmi, Sandra Schneid, Eric J. Lambie, Simon Haeussler, Bianca Habermann, Dejana Mokranjac, Stéphane G. Rolland, Melanie Schwarz

Publikováno v: Cell Reports, Vol 28, Iss 7, Pp 1659-1669.e5 (2019)
Cell Reports
Cell Reports, Elsevier Inc, 2019, 28 (7), pp.1659-1669.e5. ⟨10.1016/j.celrep.2019.07.049⟩
Cell Reports, 2019, 28 (7), pp.1659-1669.e5. ⟨10.1016/j.celrep.2019.07.049⟩

Summary: The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C. elegans genome and identified 171 genes that, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba6e19b77a83c3a5e1fe1def25bfd78
http://www.sciencedirect.com/science/article/pii/S2211124719309532

MitoSegNet: Easy-to-use Deep Learning Segmentation for Analyzing Mitochondrial Morphology

Autor: Carsten Marr, Christian Fischer, Stéphane G. Rolland, Laura Besora-Casals, Kritarth Singh, Barbara Conradt, Michael R. Duchen, Simon Haeussler

Publikováno v: iScience, Vol 23, Iss 10, Pp 101601-(2020)
iScience
iScience 23:101601 (2020)

Summary While the analysis of mitochondrial morphology has emerged as a key tool in the study of mitochondrial function, efficient quantification of mitochondrial microscopy images presents a challenging task and bottleneck for statistically robust c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2e4b36046bdb3a21e5c9531b8de0f6
http://www.sciencedirect.com/science/article/pii/S2589004220307938

Reduced peroxisomal import triggers peroxisomal retrograde signaling

Autor: Axel Imhof, Judith Zacherl, Elisabeth Rackles, Christian Fischer, Jonathan J. Ewbank, Michael Witting, Ignasi Forné, Stéphane G. Rolland, Christof Osman, Simon Schrott, Xing Zhang

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 34, ⟨10.1016/j.celrep.2020.108653⟩
Cell Reports, 2021, 34, ⟨10.1016/j.celrep.2020.108653⟩
Cell Rep. 34:108653 (2021)

Summary Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308daf5f86ef5f78c743d20bc209c613
https://pubmed.ncbi.nlm.nih.gov/33472070