Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Stéphane Depil"'
Autor:
Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot, Julien Valton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Engineered T cells work as living therapeutics, but are prone to hyperreactivity and exhaustion. Here the authors improve CAR T cell antitumor responses by simultaneously targeting a CAR to TCR locus and IL-12 to PD1 locus, placing the transgenes und
Externí odkaz:
https://doaj.org/article/981675c72a9b4f029d140df08e0be5fe
Autor:
Alexandre Juillerat, Diane Tkach, Brian W. Busser, Sonal Temburni, Julien Valton, Aymeric Duclert, Laurent Poirot, Stéphane Depil, Philippe Duchateau
Publikováno v:
BMC Biotechnology, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Engineered therapeutic cells have attracted a great deal of interest due to their potential applications in treating a wide range of diseases, including cancer and autoimmunity. Chimeric antigen receptor (CAR) T-cells are designed
Externí odkaz:
https://doaj.org/article/380bd0d729ef46438acb5f2ab48d53a9
Autor:
Paola Bonaventura, Tala Shekarian, Vincent Alcazer, Jenny Valladeau-Guilemond, Sandrine Valsesia-Wittmann, Sebastian Amigorena, Christophe Caux, Stéphane Depil
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains relatively low in most cases. A major factor involved in initial resistance to ICP inhibitors is
Externí odkaz:
https://doaj.org/article/f5194aaa4fd842d8b84b2a03d16652fb
Autor:
Mohit Sachdeva, Brian W. Busser, Sonal Temburni, Billal Jahangiri, Anne-Sophie Gautron, Alan Maréchal, Alexandre Juillerat, Alan Williams, Stéphane Depil, Philippe Duchateau, Laurent Poirot, Julien Valton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/e8570c25336b48d493105f24be42908c
Autor:
Fariba Némati, Catherine de Montrion, Guillaume Lang, Laurence Kraus-Berthier, Guillaume Carita, Xavier Sastre-Garau, Aurélie Berniard, David Vallerand, Olivier Geneste, Ludmilla de Plater, Alain Pierré, Brian Lockhart, Laurence Desjardins, Sophie Piperno-Neumann, Stéphane Depil, Didier Decaudin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e80836 (2014)
PurposeUveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression
Externí odkaz:
https://doaj.org/article/76fbfa490b634f1296b2e0f84faf5e90
Autor:
Mélanie Gressette, Benjamin Vérillaud, Anne-Sophie Jimenez-Pailhès, Hélène Lelièvre, Kwok-Wai Lo, François-Régis Ferrand, Charles-Henry Gattolliat, Anne Jacquet-Bescond, Laurence Kraus-Berthier, Stéphane Depil, Pierre Busson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91325 (2014)
EBV-related nasopharyngeal carcinomas (NPCs) still raise serious therapeutic problems. The therapeutic potential of the histone-deacetylase (HDAC) inhibitor Abexinostat was investigated using 5 preclinical NPC models including 2 patient-derived xenog
Externí odkaz:
https://doaj.org/article/ac873fcec6e74f7cbea460e0e8f5acb4
Autor:
Virginie Maire, Céline Baldeyron, Marion Richardson, Bruno Tesson, Anne Vincent-Salomon, Eléonore Gravier, Bérengère Marty-Prouvost, Leanne De Koning, Guillem Rigaill, Aurélie Dumont, David Gentien, Emmanuel Barillot, Sergio Roman-Roman, Stéphane Depil, Francisco Cruzalegui, Alain Pierré, Gordon C Tucker, Thierry Dubois
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63712 (2013)
Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potentia
Externí odkaz:
https://doaj.org/article/dcb4815980244faa8e17e979409ecdb7
Autor:
Marion Mallet, Rasha E. Boulos, Vincent Alcazer, Paola Bonaventura, Yann Estornes, Nicolas Chuvin, Stéphane Depil
Publikováno v:
European Journal of Cancer. 171:96-105
Cancer vaccines and T-cell receptor (TCR) engineered T cells (Tg-T cell) represent two different therapeutic strategies that can target the same tumour epitopes. The first approach requires the induction of a specific immune response in patients, whi
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Pharmacokinetic parameters of S49076 administered orally to female balb/c nu/nu mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d85780489a7d5f2f98bfaf00e0d717
https://doi.org/10.1158/1535-7163.22500580.v1
https://doi.org/10.1158/1535-7163.22500580.v1
Autor:
Stéphane Depil, Francisco H. Cruzalegui, John A. Hickman, Alain Pierré, Jean-Claude Ortuno, Alex Cordi, Jean A. Boutin, Brian P. Lockhart, Paolo M. Comoglio, Anne Jacquet-Bescond, Valérie Cattan, François Bouzom, Georges Da Violante, Gilles Ferry, Stéphane Léonce, Alain Bruno, Imre Fejes, Carine Saunier, Céline J. Bossard, Mike F. Burbridge
Aberrant activity of the receptor tyrosine kinases MET, AXL, and FGFR1/2/3 has been associated with tumor progression in a wide variety of human malignancies, notably in instances of primary or acquired resistance to existing or emerging anticancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430099b575997bc84c21ebae598114d2
https://doi.org/10.1158/1535-7163.c.6536506.v1
https://doi.org/10.1158/1535-7163.c.6536506.v1