Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stéphane Ciblat"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Publikováno v:
Tetrahedron: Asymmetry. 11:2211-2219
An improved enantioselective synthesis (five steps, 37–44% yield versus seven to 10 steps, 13.5 and 12% yield, respectively) of both enantiomers of keto-protected 4-amino-2-pentanone has been realized, the key step being the microbiological reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a955d2f20d02dab2d08f28f5bf6cd15
https://doi.org/10.1016/s0957-4166(00)00167-1
https://doi.org/10.1016/s0957-4166(00)00167-1
Publikováno v:
Tetrahedron: Asymmetry. 10:2213-2224
An acetal protected 4-amino-2-pentanone was synthesised by two different routes in 10 and seven steps, respectively, the key step being a microbiological reduction. Both enantiomers of the amine were obtained enantiomerically pure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa23deb2a8e0e97e473224f0310d62c5
https://doi.org/10.1016/s0957-4166(99)00234-7
https://doi.org/10.1016/s0957-4166(99)00234-7
Autor:
Francis, Arhin, Odette, Bélanger, Stéphane, Ciblat, Mohammed, Dehbi, Daniel, Delorme, Evelyne, Dietrich, Dilip, Dixit, Yanick, Lafontaine, Dario, Lehoux, Jing, Liu, Geoffrey A, McKay, Greg, Moeck, Ranga, Reddy, Yannick, Rose, Ramakrishnan, Srikumar, Kelly S E, Tanaka, Daniel M, Williams, Philippe, Gros, Jerry, Pelletier, Thomas R, Parr, Adel Rafai, Far
Publikováno v:
Bioorganicmedicinal chemistry. 14(17)
The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput screening program based on this enzyme from Staphylococcus aureus had previously identified a 2-ureidothiophene-3-carboxylate as a low micromolar inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98209a7c5a9bda3e658ad9cb8529f1f8
https://pubmed.ncbi.nlm.nih.gov/16759869
https://pubmed.ncbi.nlm.nih.gov/16759869