Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stéphane Angers"'
Autor:
Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The release of Ca2+ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca2+ often occurs through inositol 1,4,5-triphos
Externí odkaz:
https://doaj.org/article/621bb704143344139070befe42b1c5d8
Autor:
Junfeng Han, Ming Zhang, Sean Froese, Feihan F Dai, Mélanie Robitaille, Alpana Bhattacharjee, Xinyi Huang, Weiping Jia, Stéphane Angers, Michael B Wheeler, Li Wei
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129226 (2015)
Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important to unders
Externí odkaz:
https://doaj.org/article/a19615632d2d4745b3ae5d21afc23784
Autor:
Yassine El Bakkouri, Rony Chidiac, Chantal Delisle, Jeanne Corriveau, Gael Cagnone, Vanda Gaonac’h-Lovejoy, Ashley Chin, Éric Lécuyer, Stephane Angers, Jean-Sébastien Joyal, Ivan Topisirovic, Laura Hulea, Alexandre Dubrac, Jean-Philippe Gratton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions with RNA-binding proteins that are part of stress gra
Externí odkaz:
https://doaj.org/article/95ff214a0fa9446fbd3a459e08308533
Autor:
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA polymerase II (Pol II), and t
Externí odkaz:
https://doaj.org/article/29852213a0ff4f3898e31bb9afc0393f
Autor:
Benoît Vanderperre, Amitha Muraleedharan, Frédérique Larroquette, Rony Chidiac, Charlotte Tardif, Nishani Rajakulendran, Graham Macleod, Roxanne Larivière, Esther Del Cid Pellitero, Rhalena Thomas, Thomas Durcan, Stephane Angers, Edward Fon
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S459- (2023)
Externí odkaz:
https://doaj.org/article/f0de68d0b5dc43609a5dcbcc8605236a
Autor:
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target whic
Externí odkaz:
https://doaj.org/article/875e347a38ed42f697dc3427cce904d4
Autor:
Lingling Zhang, Md. Abedin, Ha-Neul Jo, Jacklyn Levey, Quynh Chau Dinh, Zhe Chen, Stephane Angers, Harald J. Junge
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107415- (2023)
Summary: Norrin (NDP) and WNT7A/B induce and maintain the blood-brain and blood-retina barrier (BBB, BRB) by stimulating the Frizzled4-LDL receptor related protein 5/6 (FZD4-LRP5/6) complex to induce beta-catenin-dependent signaling in endothelial ce
Externí odkaz:
https://doaj.org/article/fffa45f051214dd5a60a83b32119997b
Autor:
Rhiannon, Campden, Darlaine, Pétrin, Mélanie, Robitaille, Nicolas, Audet, Sarah, Gora, Stéphane, Angers, Terence E, Hébert
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1234
It has become clear in recent years that the Gβγ subunits of heterotrimeric proteins serve broad roles in the regulation of cellular activity and interact with many proteins in different subcellular locations including the nucleus. Protein affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99bd253c4a8fc7b5f61bd0a102525066
https://pubmed.ncbi.nlm.nih.gov/25304356
https://pubmed.ncbi.nlm.nih.gov/25304356
Autor:
David N. Philpott, Surath Gomis, Hansen Wang, Randy Atwal, Abdellali Kelil, Tanja Sack, Brandon Morningstar, Chris Burnie, Edward H. Sargent, Stephane Angers, Sachdev Sidhu, Shana O. Kelley
Publikováno v:
ACS Central Science, Vol 8, Iss 1, Pp 102-109 (2021)
Externí odkaz:
https://doaj.org/article/1018965999b24e8ba5d6ffcea7f2789f
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy
Autor:
Rony Chidiac, Md. Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha‐Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-16 (2021)
Abstract The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of the blood–retina–barrier during development and its homeostasis in adults. Mu
Externí odkaz:
https://doaj.org/article/823716d920524f3b8debfe84b49df873