Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Stéphane ANSIEAU"'
Autor:
François Virard, Stéphane Giraud, Mélanie Bonnet, Léa Magadoux, Laetitia Martin, Thuy Ha Pham, Najwa Skafi, Sophie Deneuve, Rita Frem, Bruno O. Villoutreix, Nawal Hajj Sleiman, Jonathan Reboulet, Samir Merabet, Vincent Chaptal, Cédric Chaveroux, Nader Hussein, Nicolas Aznar, Tanguy Fenouil, Isabelle Treilleux, Pierre Saintigny, Stéphane Ansieau, Serge Manié, Serge Lebecque, Toufic Renno, Isabelle Coste
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The quest for targeted therapies is critical in the battle against cancer. The RAS/MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous
Externí odkaz:
https://doaj.org/article/5f91f695de8442caa6ead3b1243c6294
Autor:
Geoffrey Richard, Stéphane Dalle, Marie‐Ambre Monet, Maud Ligier, Amélie Boespflug, Roxane M Pommier, Arnaud de la Fouchardière, Marie Perier‐Muzet, Lauriane Depaepe, Romain Barnault, Garance Tondeur, Stéphane Ansieau, Emilie Thomas, Corine Bertolotto, Robert Ballotti, Samia Mourah, Maxime Battistella, Céleste Lebbé, Luc Thomas, Alain Puisieux, Julie Caramel
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 10, Pp 1143-1161 (2016)
Abstract Targeted therapies with MAPK inhibitors (MAPKi) are faced with severe problems of resistance in BRAF‐mutant melanoma. In parallel to the acquisition of genetic mutations, melanoma cells may also adapt to the drugs through phenotype switchi
Externí odkaz:
https://doaj.org/article/0023004682874f4b9e536fd58b70cb1e
Autor:
Laurent Jacqueroud, Charlotte Bouard, Geoffrey Richard, Léa Payen, Mojgan Devouassoux-Shisheboran, Douglas B. Spicer, Julie Caramel, Guillaume Collin, Alain Puisieux, Agnès Tissier, Stéphane Ansieau
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 5, Pp 317-327 (2016)
The TWIST1 embryonic transcription factor displays biphasic functions during the course of carcinogenesis. It facilitates the escape of cells from oncogene-induced fail-safe programs (senescence, apoptosis) and their consequent neoplastic transformat
Externí odkaz:
https://doaj.org/article/37d9570f42444163885d0460850f63e5
Autor:
Baptiste Gras, Laurent Jacqueroud, Anne Wierinckx, Christelle Lamblot, Frédérique Fauvet, Joël Lachuer, Alain Puisieux, Stéphane Ansieau
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92254 (2014)
By fostering cell commitment to the epithelial-to-mesenchymal transition (EMT), SNAIL proteins endow cells with motility, thereby favoring the metastatic spread of tumor cells. Whether the phenotypic change additionally facilitates tumor initiation h
Externí odkaz:
https://doaj.org/article/1632780bb24d49aaacefdffef0c2f107
Autor:
Nicolas Floc'h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stéphane Ansieau, Alain Puisieux, Urszula Hibner, Patrice Lassus
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72490 (2013)
Expression of developmental genes Twist1 and Twist2 is reactivated in many human tumors. Among their oncogenic activities, induction of epithelial to mesenchymal transition is believed to increase cell motility and invasiveness and may be related to
Externí odkaz:
https://doaj.org/article/b2d23ee5fc534f148181b316840bb382
Autor:
Anne-Pierre Morel, George W Hinkal, Clémence Thomas, Frédérique Fauvet, Stéphanie Courtois-Cox, Anne Wierinckx, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Agnès Tissier, Baptiste Gras, Julie Pourchet, Isabelle Puisieux, Gareth J Browne, Douglas B Spicer, Joël Lachuer, Stéphane Ansieau, Alain Puisieux
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002723 (2012)
The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor
Externí odkaz:
https://doaj.org/article/cea742889eda4b7e8c8e6148940ce073
Autor:
Karine Pallier, Anatole Cessot, Jean-Francois Côté, Pierre-Alexandre Just, Aurélie Cazes, Elizabeth Fabre, Claire Danel, Marc Riquet, Mojgan Devouassoux-Shisheboran, Stéphane Ansieau, Alain Puisieux, Pierre Laurent-Puig, Hélène Blons
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29954 (2012)
Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with a copy number gain at a locus encompassing the TWIST1 gene on chromosome 7. TWIST1 is a highly co
Externí odkaz:
https://doaj.org/article/0d3acebae6dd446db855594dedf8253d
Autor:
Anne-Pierre Morel, Marjory Lièvre, Clémence Thomas, George Hinkal, Stéphane Ansieau, Alain Puisieux
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2888 (2008)
Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells.
Externí odkaz:
https://doaj.org/article/c33f7ae14e62445289cf95511a9e7efb
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 2 (2008)
Cancers have long been described as the result of successive selections of somatic cells progressively acquiring growth and survival advantages. Such a model was hardly compatible with the obvious heterogeneity of the cancer cell population present i
Externí odkaz:
https://doaj.org/article/ca01ca909be349e784e85abffe447032
Autor:
Laurent Bartholin, Stéphanie Sentis, Ulrich Valcourt, Alain Puisieux, Stéphane Ansieau, Caroline Moyret-Lalle, Pascal Bernard, Geneviève Fourel, Guillaume Devailly, Bastien Kaniewski, Sylvie Martel, Vanessa Arfi, Nicolas Chuvin, Lindsay B. Alcaraz, David F. Vincent, Johann Gout, Roxane M. Pommier
Inactivation of Tif1γ in spontaneously immortalized mouse embryonic fibroblasts rapidly results in cell cycle blockade in G2/M phases, spindle checkpoint activation and mitotic catastrophe events.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055ca147c8a3066ea076a907a2cf7e3b
https://doi.org/10.1158/0008-5472.22404647.v1
https://doi.org/10.1158/0008-5472.22404647.v1
