Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Stéphane A, Laporte"'
Autor:
Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesting
Externí odkaz:
https://doaj.org/article/00c1bfe069ce44fd80ee66e1ab0d2340
Autor:
Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H. Lee, David E. Gloriam, Stéphane A. Laporte, M. Madan Babu, Nagarajan Vaidehi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
G protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein i
Externí odkaz:
https://doaj.org/article/3f58c0dca0e94af083460b63eb5f6506
Autor:
Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K. Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A. Laporte, Terence E. Hébert, Arun K. Shukla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.
Externí odkaz:
https://doaj.org/article/b914c159b8f9404cb1ff77ff55de3886
Autor:
Jenna Giubilaro, Doris A. Schuetz, Tomasz M. Stepniewski, Yoon Namkung, Etienne Khoury, Mónica Lara-Márquez, Shirley Campbell, Alexandre Beautrait, Sylvain Armando, Olivier Radresa, Jean Duchaine, Nathalie Lamarche-Vane, Audrey Claing, Jana Selent, Michel Bouvier, Anne Marinier, Stéphane A. Laporte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
While Ras is a promising target for cancer therapy, development of inhibitors targeting Ras signaling has proven challenging. Here, the authors report the discovery of Rasarfin, a small molecule from a phenotypic screen on G protein-coupled receptor
Externí odkaz:
https://doaj.org/article/ec44bf6899064e34b2049b207a9e9931
Autor:
Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, w
Externí odkaz:
https://doaj.org/article/6eba6ba8e03a459fb317fb0b5ab08460
Autor:
Yoon Namkung, Christian Le Gouill, Viktoria Lukashova, Hiroyuki Kobayashi, Mireille Hogue, Etienne Khoury, Mideum Song, Michel Bouvier, Stéphane A. Laporte
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Cellular signaling processes often involve trafficking of receptors and other proteins between subcellular compartments. Here the authors demonstrate a method based on the concept of Enhanced bystander Bioluminescence Resonance Energy Transfer (EbBRE
Externí odkaz:
https://doaj.org/article/533dd58c08184acea1bdb815fa853d15
Autor:
Joshua E. Allen, Stéphane A. Laporte, J. Robert Lane, David R. Sibley, Yoon Namkung, R. Benjamin Free, Blair K. A. Willette, Bing Xie, Marta Sánchez-Soto, Caroline A. Cuoco, Varun V. Prabhu, Lei Shi, Marilyn M. Day
Publikováno v:
Mol Pharmacol
ONC201 is a first-in-class imipridone compound that is in clinical trials for the treatment of high-grade gliomas and other advanced cancers. Recent studies identified that ONC201 antagonizes D2-like dopamine receptors at therapeutically relevant con
Autor:
Parishmita Sarma, Hye-Jin Yoon, Carlo Marion C. Carino, Deeksha S, Ramanuj Banerjee, Yaejin Yun, Jeongsek Ji, Kyungjin Min, Shubhi Pandey, Hemlata Dwivedi-Agnihotri, Xue Rui, Yubo Cao, Kouki Kawakami, Poonam Kumari, Yu-Chih Chen, Kathryn E. Luker, Manish K. Yadav, Ashutosh Ranjan, Madhu Chaturvedi, Jagannath Maharana, Mithu Baidya, Prem N. Yadav, Gary D. Luker, Stéphane A. Laporte, Xin Chen, Asuka Inoue, Hyung Ho Lee, Arun K. Shukla
Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesting target t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b46111109a2a0f8be1f755063459da6
https://doi.org/10.1101/2022.06.06.494935
https://doi.org/10.1101/2022.06.06.494935
Autor:
Dana Sedki, Aaron Cho, Yubo Cao, Ljiljana Nikolajev, N. D. Prasad Atmuri, William D. Lubell, Stéphane A. Laporte
Publikováno v:
The Journal of biological chemistry. 298(9)
Promiscuous G protein-coupled receptors (GPCRs) engage multiple Gα subtypes with different efficacies to propagate signals in cells. A mechanistic understanding of Gα selectivity by GPCRs is critical for therapeutic design, since signaling can be r
Publikováno v:
J Biol Chem
The angiotensin II (AngII) type 1 receptor (AT1R), a member of the G protein–coupled receptor (GPCR) family, signals through G proteins and β-arrestins, which act as adaptors to regulate AT1R internalization and mitogen-activated protein kinase (M