Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

Autor: Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Raki Sudan, Elizabeth A. Luke, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Stéphane Schurmans, Benedict J. Chambers, John D. Chisholm, William G. Kerr

Publikováno v: iScience, Vol 26, Iss 2, Pp 106071- (2023)

Summary: Here we extend the understanding of how chemical inhibition of SHIP paralogs controls obesity. We compare different classes of SHIP inhibitors and find that selective inhibitors of SHIP1 or SHIP2 are unable to prevent weight gain and body fa

Externí odkaz: https://doaj.org/article/193eb622fd5540ccb7390064bb00037e

INPP5K controls the dynamic structure and signaling of wild-type and mutated, leukemia-associated IL-7 receptors

Autor: Bastien Moës, Hua Li, Patricia Molina-Ortiz, Coraline Radermecker, Adeline Rosu, Charles-Andrew Vande Catsyne, Sufyan Ali Sayyed, João Fontela, Mafalda Duque, Alice Mostafa, Abdelhalim Azzi, João T. Barata, Ramon Merino, Chenqi Xu, Christophe J. Desmet, Stéphane Schurmans

© 2023 by The American Society of Hematology.
The downstream signaling of the interleukin-7 (IL-7) receptor (IL-7R) plays important physiological and pathological roles, including the differentiation of lymphoid cells and proliferation of acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f9fcd890a705808b71f4b24b189789
https://hdl.handle.net/10451/57105

Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet.

Autor: Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans

Publikováno v: PLoS Genetics, Vol 10, Iss 6, p e1004420 (2014)

Rasa3 is a GTPase activating protein of the GAP1 family which targets Ras and Rap1. Ubiquitous Rasa3 catalytic inactivation in mouse results in early embryonic lethality. Here, we show that Rasa3 catalytic inactivation in mouse hematopoietic cells re

Externí odkaz: https://doaj.org/article/9763e739b9604a65a866f66730834f48

The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment

Autor: Stéphane Schurmans, Karen E. Anderson, Utsa Karmakar, Augustin Amour, Barry McCormick, Melina Michael, Sonja Vermeren, Matthieu Vermeren

Publikováno v: Michael, M, Mccormick, B, Anderson, K E, Karmakar, U, Vermeren, M, Schurmans, S, Amour, A & Vermeren, S 2021, ' The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment ', Frontiers in Immunology, vol. 12 . https://doi.org/10.3389/fimmu.2021.671756
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of neutrophil biology. PIP3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3245c88952a0b524d39c09248f76aadd
https://doi.org/10.3389/fimmu.2021.671756

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+mobilization and the inflammatory activity of dendritic cells

Autor: Laura Marongiu, Reiko Sakaguchi, Takashi Morii, Tiziano Catelani, Miriam Colombo, Davide Prosperi, Francesca Mingozzi, Rany Rotem, Massimiliano Garrè, Dario Parazzoli, Francesca Granucci, Monica Moro, Stéphane Schurmans, Roberta Marzi, Clara Cigni, Laura Sironi, Maddalena Collini, Marco Di Gioia, Mariacristina Crosti, Stephen B. Shears, Ivan Zanoni

Innate immune responses to Gram-negative bacteria depend on the recognition of lipopolysaccharide (LPS) by a receptor complex that includes CD14 and TLR4. In dendritic cells (DCs), CD14 enhances the activation not only of TLR4 but also that of the NF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14f92b88a1f9a875aa8f2d180ac2605
http://hdl.handle.net/10281/313899