Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Stéphane, Massé"'
Autor:
Yanan Zhao, Beibei Du, Praloy Chakraborty, Nathan Denham, Stéphane Massé, Patrick F.H. Lai, Mohammed Ali Azam, Filio Billia, Paaladinesh Thavendiranathan, Husam Abdel‐Qadir, Gary D. Lopaschuk, Kumaraswamy Nanthakumar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Background We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability. A pathway of ibrutinib‐induced vulner
Externí odkaz:
https://doaj.org/article/b2f674f7a00f4bfabfc90509645f8705
Autor:
Keith Dadson, PhD, Paaladinesh Thavendiranathan, MD, SM, Ludger Hauck, PhD, Daniela Grothe, Mohammed Ali Azam, MBBS, PhD, Shanna Stanley-Hasnain, MSc, Donya Mahiny-Shahmohammady, BSc, Daoyuan Si, MD, PhD, Mahmoud Bokhari, MD, Patrick F.H. Lai, MSc, Stéphane Massé, MASc, Kumaraswamy Nanthakumar, MD, Filio Billia, MD, PhD
Publikováno v:
CJC Open, Vol 4, Iss 12, Pp 1043-1052 (2022)
Background: Doxorubicin-induced cardiomyopathy (DICM) is one of the complications that can limit treatment for a significant number of cancer patients. In animal models, the administration of statins can prevent the development of DICM. Therefore, th
Externí odkaz:
https://doaj.org/article/c86b0b14759e4a9d902608a4ef2a3376
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290676 (2023)
Chronic stress among young patients (≤ 45 years old) could result in autonomic dysfunction. Autonomic dysfunction could be exhibited via sympathetic hyperactivity, sympathetic nerve sprouting, and diffuse adrenergic stimulation in the atria. Adrene
Externí odkaz:
https://doaj.org/article/9993a507927b4a4c9de804051fdc76d5
Autor:
Mohammed Ali Azam, MBBS, PhD, Praloy Chakraborty, MD, Mahmoud M. Bokhari, MBBS, Keith Dadson, PhD, Beibei Du, MD, PhD, Stéphane Massé, MASc, Daoyuan Si, MD, PhD, Ahmed Niri, BEng, Arjun K. Aggarwal, Patrick F.H. Lai, MSc, Sheila Riazi, MD, MSc, Filio Billia, MD, PhD, Kumaraswamy Nanthakumar, MD
Publikováno v:
Heart Rhythm O2, Vol 2, Iss 6, Pp 733-741 (2021)
Background: Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardio
Externí odkaz:
https://doaj.org/article/520ddf0a2c92488dace35e0269037145
Autor:
Rocco Romagnuolo, Hassan Masoudpour, Andreu Porta-Sánchez, Beiping Qiang, Jennifer Barry, Andrew Laskary, Xiuling Qi, Stéphane Massé, Karl Magtibay, Hiroyuki Kawajiri, Jun Wu, Tamilla Valdman Sadikov, Janet Rothberg, Krishna M. Panchalingam, Emily Titus, Ren-Ke Li, Peter W. Zandstra, Graham A. Wright, Kumaraswamy Nanthakumar, Nilesh R. Ghugre, Gordon Keller, Michael A. Laflamme
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 967-981 (2019)
Summary: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show considerable promise for regenerating injured hearts, and we therefore tested their capacity to stably engraft in a translationally relevant preclinical model, the infarcted pi
Externí odkaz:
https://doaj.org/article/ad093f74841a4338ad1827950acddd0d
Autor:
Maroosh Mumtaz, Eugene Downar, Satoshi Kawada, Melanie Zammit-Burg, Robert Anderson, Stéphane Massé, Madhav Krishna Kumar Nair, Jared Nanthakumar, Fateh Muhammad Ghauri, Andreu Porta- Sánchez, Abhishek Bhaskaran
Publikováno v:
Canadian Journal of Cardiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb64a0d9ba64483cd7384aafbabefacc
https://doi.org/10.1016/j.cjca.2023.02.074
https://doi.org/10.1016/j.cjca.2023.02.074
Autor:
Robert D. Anderson, Stéphane Massé, John Asta, Patrick F.H. Lai, Praloy Chakraborty, Mohammed Ali Azam, Eugene Downar, Kumaraswamy Nanthakumar
Publikováno v:
Pacing and Clinical Electrophysiology. 45:742-751
The role of the Purkinje network in triggering ventricular fibrillation (VF) has been studied; however, its involvement after onset and in early maintenance of VF is controversial.We studied the role of the Purkinje-muscle junctions (PMJ) on epicardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c80f38febb2f571aae652335147a71
https://doi.org/10.1111/pace.14453
https://doi.org/10.1111/pace.14453
Autor:
Praloy Chakraborty, Stéphane Massé, Mohammed Ali Azam, Catherine Thollon, Ahmed Niri, Patrick F.H. Lai, Muriel Bouly, Sheila Riazi, Kumaraswamy Nanthakumar
Publikováno v:
Biochemical and Biophysical Research Communications. 600:123-129
Proarrhythmic risk of conventional anti-arrhythmic agents is linked to unintended modulation of membrane voltage dynamics. We have demonstrated that the anti-fibrillatory effect of azumolene is mediated via stabilization of the hyperphosphorylated ry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4042b3bde1a8a5ce080db6e74908c5c5
https://doi.org/10.1016/j.bbrc.2022.02.031
https://doi.org/10.1016/j.bbrc.2022.02.031
Autor:
Karl Magtibay, Stéphane Massé, Kumaraswamy Nanthakumar, Ahmed Niri, Robert D. Anderson, Ram B. Kumar, D. Curtis Deno
Publikováno v:
Heart Rhythm O2
Background Sites of local abnormal ventricular activation (LAVA) are ventricular tachycardia (VT) ablation targets. In nonischemic cardiomyopathy (NICM), minute and sparse LAVA potentials are mapped with difficulty with direction-sensitive bipolar el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a428cb9ffd112c15b6d3ee169d32a11
http://europepmc.org/articles/PMC8505212
http://europepmc.org/articles/PMC8505212
Autor:
Arulalan Velluppillai, Abhishek Bhaskaran, Eugene Downar, Ahmed Niri, Michiel J Janse, Kumaraswamy Nanthakumar, Stéphane Massé
Publikováno v:
Pacing and Clinical Electrophysiology. 44:1781-1785
Background Spontaneous ventricular premature contractions (PVCs) and ventricular tachycardia (VT) in the acute post infarct milieu is assumed to be due to automaticity. However, the mechanism has not been studied with intramural mapping. Objective To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edde41fad9082daaddbea93731241859
https://doi.org/10.1111/pace.14326
https://doi.org/10.1111/pace.14326