The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice

Autor: Mathieu Favier, Elena Martin Garcia, Romain Icick, Camille de Almeida, Joachim Jehl, Mazarine Desplanque, Johannes Zimmermann, Annabelle Henrion, Nina Mansouri-Guilani, Coline Mounier, Svethna Ribeiro, Fiona Henderson, Andrea Geoffroy, Sebastien Mella, Odile Poirel, Véronique Bernard, Véronique Fabre, Yulong Li, Christian Rosenmund, Stéphane Jamain, Florence Vorspan, Alexandre Mourot, Philibert Duriez, Leora Pinhas, Rafael Maldonado, Nicolas Pietrancosta, Stéphanie Daumas, Salah El Mestikawy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh

Externí odkaz: https://doaj.org/article/92f0421dd9334d49b5771f81a762f0c7

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling

Autor: Ana Sofia Lima Estevao de Oliveira, Giovanna Bloise, Chiara Moltrasio, Antonio Coelho, Almerinda Agrelli, Ronald Moura, Paola Maura Tricarico, Stéphane Jamain, Angelo Valerio Marzano, Sergio Crovella, Lucas André Cavalcanti Brandão

Publikováno v: Biomolecules, Vol 12, Iss 10, p 1371 (2022)

Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, groins, and buttocks. Despite m

Externí odkaz: https://doaj.org/article/266bcbb36c9146a19b170f66ec872e38

Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders

Autor: Cécile Pagan, Hany Goubran-Botros, Richard Delorme, Marion Benabou, Nathalie Lemière, Kerren Murray, Frédérique Amsellem, Jacques Callebert, Pauline Chaste, Stéphane Jamain, Fabien Fauchereau, Guillaume Huguet, Erik Maronde, Marion Leboyer, Jean-Marie Launay, Thomas Bourgeron

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical heterogeneity. However, some biochemical impairments, including decreased melatonin (crucial for circadian regulation) and elevated platelet N-acetylserotonin (

Externí odkaz: https://doaj.org/article/f46cefc850c64dbfa6f36f39d8a0b82c

Risperidone response in patients with schizophrenia drives DNA methylation changes in immune and neuronal systems

Autor: Ana Lokmer, Charanraj Goud Alladi, Réjane Troudet, Delphine Bacq-Daian, Anne Boland-Auge, Violaine Latapie, Jean-François Deleuze, Ravi Philip RajKumar, Deepak Gopal Shewade, Frank Bélivier, Cynthia Marie-Claire, Stéphane Jamain

Publikováno v: Epigenomics
Epigenomics, 2023, ⟨10.2217/epi-2023-0017⟩

Background: The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens of the disease call for faster alternatives. Material \& methods: In a search for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6c94243c03876464b988f55d6a7217
https://www.hal.inserm.fr/inserm-04044562

Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder

Autor: Céline S. Reinbold, Andreas J. Forstner, Julian Hecker, Janice M. Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Antonio Benabarre, Susanne Bengesser, Abesh K. Bhattacharjee, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Scott R. Clark, Francesc Colom, David A. Cousins, Cristiana Cruceanu, Piotr M. Czerski, Alexandre Dayer, Bruno Étain, Peter Falkai, Louise Frisén, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Stéphane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Carlos A. López Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J. McCarthy, Susan L. McElroy, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Urban Ösby, Norio Ozaki, Roy H. Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A. Rouleau, Peter R. Schofield, K. Oliver Schubert, Barbara W. Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M. Slaney, Jordan W. Smoller, Alessio Squassina, Thomas J. Stamm, Pavla Stopkova, Sarah K. Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H. Witt, Adam J. Wright, L. Trevor Young, Peter P. Zandi, James B. Potash, J. Raymond DePaulo, Michael Bauer, Eva Reininghaus, Tomáš Novák, Jean-Michel Aubry, Mario Maj, Bernhard T. Baune, Philip B. Mitchell, Eduard Vieta, Mark A. Frye, Janusz K. Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R. Wray, John R. Kelsoe, Martin Alda, Francis J. McMahon, Thomas G. Schulze, Marcella Rietschel, Markus M. Nöthen, Sven Cichon

Publikováno v: Frontiers in Psychiatry, Vol 9 (2018)

Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable.

Externí odkaz: https://doaj.org/article/cf4d7f7f904e46868d9066fab442be7b