Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

Autor: Alexander Rouvinski, Wanwisa Dejnirattisai, Pablo Guardado-Calvo, Marie-Christine Vaney, Arvind Sharma, Stéphane Duquerroy, Piyada Supasa, Wiyada Wongwiwat, Ahmed Haouz, Giovanna Barba-Spaeth, Juthathip Mongkolsapaya, Félix A. Rey, Gavin R. Screaton

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to in

Externí odkaz: https://doaj.org/article/c0392b2c359d48c4a3fd76ff74086826

The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses

Autor: Gavin R. Screaton, Pablo Guardado-Calvo, Félix A. Rey, Xinghong Dai, Danyang Gong, Patrick England, Alexander Rouvinski, Marie-Christine Vaney, Ahmed Haouz, Z. Hong Zhou, Wanwisa Dejnirattisai, Stéphane Duquerroy, Ren Sun, Arvind Sharma, Xiaokang Zhang, Wiyada Wongwiwat, Juthathip Mongkolsapaya

Publikováno v: Cell
Cell, 2021, 184 (25), pp.6052-6066.e18. ⟨10.1016/j.cell.2021.11.010⟩
'Cell ', vol: 184, pages: 6052-6066 (2021)

International audience; The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1-DENV4). Here we describe a comparative structure-function analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed324443d134d4421f6eaae4a0c0717
https://hal-pasteur.archives-ouvertes.fr/pasteur-03524447/document

Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak.

Autor: Isabelle Schuffenecker, Isabelle Iteman, Alain Michault, Séverine Murri, Lionel Frangeul, Marie-Christine Vaney, Rachel Lavenir, Nathalie Pardigon, Jean-Marc Reynes, François Pettinelli, Leon Biscornet, Laure Diancourt, Stéphanie Michel, Stéphane Duquerroy, Ghislaine Guigon, Marie-Pascale Frenkiel, Anne-Claire Bréhin, Nadège Cubito, Philippe Desprès, Frank Kunst, Félix A Rey, Hervé Zeller, Sylvain Brisse

Publikováno v: PLoS Medicine, Vol 3, Iss 7, p e263 (2006)

BackgroundA chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the dis

Externí odkaz: https://doaj.org/article/ee8541a6393444fb982fd7eae5c51499

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

Autor: Mohamed Ouizougun-Oubari, Patrick England, Patrick Couvreur, Sylviane Hoos, Safa Lassoued, Jenna Fix, Félix A. Rey, Christina Sizun, M. Alejandra Tortorici, Bogdan Tarus, Jean-François Eléouët, François Bontems, Bruno Baron, Anny Slama-Schwok, Marie Galloux, N. Pereira, Stéphane Duquerroy, Didier Desmaële

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2015, 89 (21), pp.11129-11143. ⟨10.1128/JVI.01612-15⟩
Journal of Virology, 2015, 89 (21), pp.11129-11143. ⟨10.1128/JVI.01612-15⟩

Presently, respiratory syncytial virus (RSV), the main cause of severe respiratory infections in infants, cannot be treated efficiently with antivirals. However, its RNA-dependent polymerase complex offers potential targets for RSV-specific drugs. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86554ccaf6f4bd9b41293f3b104e8ce1
https://doi.org/10.1128/jvi.01612-15

Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

Autor: Theodoros Goulas, Stéphane Duquerroy, F. Xavier Gomis-Rüth, Josué Gómez-Blanco, Irene Garcia-Ferrer, Daniel Luque, José R. Castón, Pedro Arêde

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)

This article contains supporting information online (a detailed description of the experimental procedures is provided in the SI Appendix. The latter also includes four supplementary tables, 10 supplementary figures, the Acknowledgments, and SI Appen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea04e1d656ebe46cfbf255058808bdd1
https://pubmed.ncbi.nlm.nih.gov/26100869