Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Sruti Shiva"'
Autor:
Niranjana Natarajan, Jonathan Florentin, Ebin Johny, Hanxi Xiao, Scott Patrick O’Neil, Liqun Lei, Jixing Shen, Lee Ohayon, Aaron R. Johnson, Krithika Rao, Xiaoyun Li, Yanwu Zhao, Yingze Zhang, Sina Tavakoli, Sruti Shiva, Jishnu Das, Partha Dutta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract There is a large body of evidence that cellular metabolism governs inflammation, and that inflammation contributes to the progression of atherosclerosis. However, whether mitochondrial DNA synthesis affects macrophage function and atheroscle
Externí odkaz:
https://doaj.org/article/bde5cd6bc7f3482fbd56713b275d5b67
Autor:
Xiaotong Li, Xinlei Chen, David T Huang, Chung-Chou H Chang, John Kellum, Ivan E Saraiva, Natsumi Hamahata, Sandra L Kane-Gill, Ryan M Rivosecchi, Sruti Shiva, Thomas D Nolin, John Minturn, Hernando Gómez
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Acute kidney injury (AKI) is a common complication of sepsis associated with increased risk of death. Preclinical data and observational human studies suggest that activation of AMP-activated protein kinase, an ubiquitous master regulato
Externí odkaz:
https://doaj.org/article/ca1a7399ecd546d8bb89af1605429d21
Autor:
Krithika Rao, Elizabeth Rochon, Anuradha Singh, Rajaganapathi Jagannathan, Zishan Peng, Haris Mansoor, Bing Wang, Mousumi Moulik, Manling Zhang, Anita Saraf, Paola Corti, Sruti Shiva
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109146- (2024)
Summary: The endogenous mechanisms that propagate cardiomyocyte differentiation and prevent de-differentiation remain unclear. While the expression of the heme protein myoglobin increases by over 50% during cardiomyocyte differentiation, a role for m
Externí odkaz:
https://doaj.org/article/37c38e76530243ab8a47fc3827429492
Autor:
Stephanie M. Casillo, Taylor A. Gatesman, Akanksha Chilukuri, Srinidhi Varadharajan, Brenden J. Johnson, Daniel R. David Premkumar, Esther P. Jane, Tritan J. Plute, Robert F. Koncar, Ann-Catherine J. Stanton, Carlos A.O. Biagi-Junior, Callie S. Barber, Matthew E. Halbert, Brian J. Golbourn, Katharine Halligan, Andrea F. Cruz, Neveen M. Mansi, Allison Cheney, Steven J. Mullett, Clinton Van’t Land, Jennifer L. Perez, Max I. Myers, Nishant Agrawal, Joshua J. Michel, Yue-Fang Chang, Olena M. Vaske, Antony MichaelRaj, Frank S. Lieberman, James Felker, Sruti Shiva, Kelsey C. Bertrand, Nduka Amankulor, Costas G. Hadjipanayis, Kalil G. Abdullah, Pascal O. Zinn, Robert M. Friedlander, Taylor J. Abel, Javad Nazarian, Sriram Venneti, Mariella G. Filbin, Stacy L. Gelhaus, Stephen C. Mack, Ian F. Pollack, Sameer Agnihotri
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113557- (2024)
Summary: Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous stu
Externí odkaz:
https://doaj.org/article/a1cfb726d57743518bf0449e2947643f
Autor:
Grace P Carreno-Florez, Brian R Kocak, Matthew R Hendricks, Jeffrey A Melvin, Katrina B Mar, Jessica Kosanovich, Rachel L Cumberland, Greg M Delgoffe, Sruti Shiva, Kerry M Empey, John W Schoggins, Jennifer M Bomberger
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011719 (2023)
Clinical studies report that viral infections promote acute or chronic bacterial infections at multiple host sites. These viral-bacterial co-infections are widely linked to more severe clinical outcomes. In experimental models in vitro and in vivo, v
Externí odkaz:
https://doaj.org/article/bc271073a1df4e65b1bf723cc4ded213
Autor:
Manisha Jhamb, Susan M. Devaraj, Maryam Alemairi, Linda-Marie Lavenburg, Sruti Shiva, Jonathan G. Yabes, Daniel E. Forman, Andrea L. Hergenroeder
Publikováno v:
Kidney Medicine, Vol 5, Iss 11, Pp 100720- (2023)
Rationale & Objective: To address the need for an intradialytic exercise program that is easily delivered in clinical setting, engaging and scalable, we developed a novel COMprehensive EXercise (COMEX) program based on input from patients receiving h
Externí odkaz:
https://doaj.org/article/86bc0f90612840e8bfced0edd62319b7
Autor:
Manling Zhang, Ning Feng, Zishan Peng, Dharendra Thapa, Michael W. Stoner, Janet R. Manning, Charles F. McTiernan, Xue Yang, Michael J. Jurczak, Danielle Guimaraes, Krithika Rao, Sruti Shiva, Brett A. Kaufman, Michael N. Sack, Iain Scott
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106942- (2023)
Summary: General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation status and activity o
Externí odkaz:
https://doaj.org/article/8909375df39c4b46833adac7bdc0ad27
Autor:
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102636- (2023)
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); howev
Externí odkaz:
https://doaj.org/article/fc1d13f5ed7a4f76bf1f12017427f9c4
Autor:
Mathijs M. de Rijk, Amanda Wolf-Johnston, Aura F. Kullmann, Stephanie Taiclet, Anthony J. Kanai, Sruti Shiva, Lori A. Birder
Publikováno v:
International Neurourology Journal, Vol 26, Iss 2, Pp 111-118 (2022)
Purpose Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the underlying bladder tissue from the h
Externí odkaz:
https://doaj.org/article/2903b18874874b06ab8c3e5f8e1687dd
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/7242e82a4e6449928d8fc7b30cae3a8b