Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sruthi Alahari"'
Autor:
Miira M. Klemetti, Ante B. V. Pettersson, Aafaque Ahmad Khan, Leonardo Ermini, Tyler R. Porter, Michael L. Litvack, Sruthi Alahari, Stacy Zamudio, Nicholas P. Illsley, Hannes Röst, Martin Post, Isabella Caniggia
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 2, Pp n/a-n/a (2024)
Abstract Small‐for‐gestational age (SGA) neonates exhibit increased perinatal morbidity and mortality, and a greater risk of developing chronic diseases in adulthood. Currently, no effective maternal blood‐based screening methods for determinin
Externí odkaz:
https://doaj.org/article/a491fef6c9d940d9a363c9b72f9e7516
Autor:
Taylor Gillmore, Abby Farrell, Sruthi Alahari, Julien Sallais, Merve Kurt, Chanho Park, Jonathan Ausman, Michael Litvack, Martin Post, Isabella Caniggia
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-14 (2022)
Abstract Dynamic changes in physiologic oxygen are required for proper placenta development; yet, when low-oxygen levels persist, placental development is halted, culminating in preeclampsia (PE), a serious complication of pregnancy. Considering mito
Externí odkaz:
https://doaj.org/article/bc9b8f18cae94d5ca33e1885a48d154c
Autor:
Julien Sallais, Chanho Park, Sruthi Alahari, Tyler Porter, Ruizhe Liu, Merve Kurt, Abby Farrell, Martin Post, Isabella Caniggia
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Preeclampsia is a serious pregnancy disorder that lacks effective treatments other than delivery. Improper sensing of oxygen changes during placentation by prolyl hydroxylases (PHDs), specifically PHD2, causes placental hypoxia-inducible factor-1 (HI
Externí odkaz:
https://doaj.org/article/63c9bc2fca0f4efba3f1b76e4bef1d50
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 932 (2023)
Disturbances of lipid metabolism are typical in diabetes. Our objective was to characterize and compare placental sphingolipid metabolism in type 1 (T1D) and 2 (T2D) diabetic pregnancies and in non-diabetic controls. Placental samples from T1D, T2D,
Externí odkaz:
https://doaj.org/article/d8132ef4516244e3ab7173db692076e9
Autor:
Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report tha
Externí odkaz:
https://doaj.org/article/f8f3d49491b44be689810b9c6842639c
Autor:
Sruthi Alahari, Abby Farrell, Leonardo Ermini, Chanho Park, Julien Sallais, Sarah Roberts, Taylor Gillmore, Michael Litvack, Martin Post, Isabella Caniggia
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O2- and Fe2+-dependent enzyme, in mediating placental fibronectin processing and functio
Externí odkaz:
https://doaj.org/article/5e0a1521e14747388abe0a71afe80bbd
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28863 (2011)
BACKGROUND:Alcohol abuse is a leading cause of pancreatitis in humans. However, rodent models suggest that alcohol only sensitizes the pancreas to subsequent insult, indicating that additional factors play a role in alcohol-induced pancreatic injury.
Externí odkaz:
https://doaj.org/article/a325d9d09c49458b9133b782987c2a8c
Autor:
Sruthi Alahari, Jonathan Ausman, Tyler Porter, Chanho Park, Ante B V Pettersson, Miira M Klemetti, Jianhong Zhang, Martin Post, Isabella Caniggia
Preeclampsia (PE) is a major obstetric complication that is challenging to predict. Currently, there are limited tools to assess placental health/function in crucial gestational periods for diagnosis and early prediction. The glycoprotein fibronectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8546ed5489c94ae15bde0c3516c17ce3
Autor:
Sruthi Alahari, Martin Post, Jayonta Bhattacharjee, Julien Sallais, Isabella Caniggia, Andrea Tagliaferro
Publikováno v:
Oncotarget
Adaptations to changes in oxygen are critical to ensure proper placental development, and impairments in oxygen sensing mechanisms characterize placental pathologies such as preeclampsia. In this study, we examined the involvement of SUMOylation, a r
Publikováno v:
Placenta. 112:e44