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of 320
pro vyhledávání: '"Srs2"'
Akademický článek
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Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT DNA-damage tolerance (DDT) is a mechanism by which eukaryotes bypass replication-blocking lesions to resume DNA synthesis and maintain cell viability. In Saccharomyces cerevisiae, DDT is mediated by sequential ubiquitination and sumoylation
Externí odkaz:
https://doaj.org/article/9068e6ca5a7f4ff2be6e8d2917db5345
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1450 (2023)
The proper maintenance of genetic material is essential for the survival of living organisms. One of the main safeguards of genome stability is homologous recombination involved in the faithful repair of DNA double-strand breaks, the restoration of c
Externí odkaz:
https://doaj.org/article/c1a65d2435924993a15b308af2c7dad1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct . 115(43), E10041-E10048.
Externí odkaz:
https://www.jstor.org/stable/26532378
Autor:
Pu Wang, Xiaocen Wang, Weirong Wang, Pengtao Gong, Nan Zhang, Renzhe Zhang, Huan Zeng, Qian Sun, Wanqing Li, Xin Li, Shuqin Cheng, Xu Zhang, Xinyi Huang, Chenyang Gao, Yadong Zheng, Jianhua Li, Xichen Zhang
Publikováno v:
Animals, Vol 12, Iss 21, p 2952 (2022)
Neosporosis is caused by Neospora caninum (N. caninum), which mainly infects cattle and goats and severely threatens the animal industry. In this study, the inhibitory effects of polyclonal antiserum anti-NcSRS17, NcSRS2 and NcSRS52 were explored. Cy
Externí odkaz:
https://doaj.org/article/56b7cf16aeaf4a29ba151674e6af99d8
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage
Externí odkaz:
https://doaj.org/article/c6fb9d83f3524b178fcfaa153a1f91ba
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1615-1626 (2018)
Proper DNA damage repair is one of the most vital and fundamental functions of every cell. Several different repair mechanisms exist to deal with various types of DNA damage, in various stages of the cell cycle and under different conditions. Homolog
Externí odkaz:
https://doaj.org/article/35de99e9b2824893b958b1af6f6a43cb
Autor:
Hunt, L.J., Ahmed, E.A., Kaur, H., Ahuja, J.S., Hulme, L., Chou, T.C., Lichten, M., Goldman, Alastair S.H.
Yes
We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilises Rad51-DNA filaments and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find tha
We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilises Rad51-DNA filaments and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find tha
Externí odkaz:
http://hdl.handle.net/10454/17048
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3166-3177 (2017)
Srs2 is a superfamily 1 (SF1) helicase and antirecombinase that is required for genome integrity. However, the mechanisms that regulate Srs2 remain poorly understood. Here, we visualize Srs2 as it acts upon single-stranded DNA (ssDNA) bound by the Ra
Externí odkaz:
https://doaj.org/article/a07f8631a2fb4ef5b5c35d232be50c04