Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sriyani Pathirathna"'
Autor:
Vesna Jevtovic-Todorovic, Kathiresan Krishnan, Michaela E. Levin, Michael T. Nelson, Won Joo Choe, Woo Yong Lee, Miljen M. Jagodic, Sriyani Pathirathna, Douglas F. Covey, Janelle R. Latham, Slobodan M. Todorovic
Publikováno v:
Diabetes
OBJECTIVE Morbid obesity may be accompanied by diabetes and painful diabetic neuropathy, a poorly understood condition that is manifested by mechanical or thermal allodynia and hyperalgesia. Recent studies have highlighted the importance of T-type ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b9e10633e1bff6c2dc225f645c695f
https://doi.org/10.2337/db08-1763
https://doi.org/10.2337/db08-1763
Publikováno v:
Neuroscience. 154:1539-1553
Neuropathic pain (NPP) due to sensory nerve injury is, in part, the result of peripheral sensitization leading to a long-lasting increase in synaptic plasticity in the spinal dorsal horn. Thus, activation of GABA-mediated inhibitory inputs from senso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af9a5514b804d070f7be079776babed
https://doi.org/10.1016/j.neuroscience.2008.04.061
https://doi.org/10.1016/j.neuroscience.2008.04.061
Autor:
Slobodan M. Todorovic, Miljen M. Jagodic, Michael T. Nelson, Vesna Jevtovic-Todorovic, Peihan Su, Woo Yong Lee, Sriyani Pathirathna, Pavle M. Joksovic, Ajit K. Naik
Publikováno v:
Journal of Neurophysiology. 99:3151-3156
Recent data indicate that peripheral T-type Ca2+ channels are instrumental in supporting acute pain transmission. However, the function of these channels in chronic pain processing is less clear. To address this issue, we studied the expression of T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77297abd879aa13b2d0a29e5483faade
https://doi.org/10.1152/jn.01031.2007
https://doi.org/10.1152/jn.01031.2007
Autor:
Vesna Jevtovic-Todorovic, Kathiresan Krishnan, Miljen M. Jagodic, Steven Mennerick, Douglas F. Covey, Charles F. Zorumski, Barbara C. Brimelow, Slobodan M. Todorovic, Sriyani Pathirathna, Xin Jiang
Publikováno v:
Pain. 114:429-443
Neurosteroids are potent blockers of neuronal low-voltage activated (T-type) Ca(2+) channels and potentiators of GABA(A) ligand-gated channels, but their effects in peripheral pain pathways have not been studied previously. To investigate potential a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8282e35c1261eb50f4a6f3c5138d4
https://doi.org/10.1016/j.pain.2005.01.009
https://doi.org/10.1016/j.pain.2005.01.009
Autor:
Douglas A. Bayliss, Stefani Mancuso, Michael T. Nelson, Ethan R Rosenberg, Pavle M. Joksovic, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic, Sriyani Pathirathna, Miljen M. Jagodic
Recent data indicate that T-type Ca2+channels are amplifiers of peripheral pain signals, but their involvement in disorders of sensory neurons such as those associated with diabetes is poorly understood. To address this issue, we used a combination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93451e265c33430d83a6f03c58ce7aa4
https://europepmc.org/articles/PMC6672477/
https://europepmc.org/articles/PMC6672477/
Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats
Publikováno v:
Pain. 125(1-2)
Previous in vivo studies indicate that locally injected redox-modulating agents can sensitize polymodal peripheral skin nociceptors resulting in acute changes in pain perception. Since endogenous thiol-modifying redox agents are normally present in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d3d6d017ffedc028b3f050376e6e5d
https://pubmed.ncbi.nlm.nih.gov/16782275
https://pubmed.ncbi.nlm.nih.gov/16782275
Publikováno v:
PainReferences. 117(3)
5alpha-reduced neuroactive steroids with selective modulatory action in vitro on T or combined modulatory action on T and GABA(A) currents present in peripheral sensory neurons have been shown to induce potent peripheral analgesia in vivo in intact a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d78721fa19514d3674a00cfec1fee6e
https://pubmed.ncbi.nlm.nih.gov/16150542
https://pubmed.ncbi.nlm.nih.gov/16150542
Autor:
Vesna Jevtovic-Todorovic, Slobodan M. Todorovic, Charles F. Zorumski, Miljen M. Jagodic, Seong-Hoon Ko, Barbara C. Brimelow, Douglas F. Covey, Kent R. Nilsson, Xin Jiang, Sriyani Pathirathna
Publikováno v:
Molecular pharmacology. 66(5)
T-type Ca(2+) channels are believed to play an important role in pain perception, and anesthetic steroids such as alphaxalone and allopregnanolone, which have a 5alpha-configuration at the steroid A, B ring fusion, are known to inhibit T-type Ca(2+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864c219b66e8c1c77632203d087706f6
https://pubmed.ncbi.nlm.nih.gov/15280444
https://pubmed.ncbi.nlm.nih.gov/15280444
Publikováno v:
Neuroscience letters. 360(1-2)
Voltage-gated Ca2+ channels expressed in neurons may contribute to nociceptive information processing. However, the role of L-type Ca2+ channels in pain transmission is not well understood. In this study, we examined the effects of systemically admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50f48f549c3c4ad59994331b0a919af
https://pubmed.ncbi.nlm.nih.gov/15082178
https://pubmed.ncbi.nlm.nih.gov/15082178