Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Srividya Sriskantharajah"'
Autor:
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G. Richter, Edward Banham-Hall, Menna R. Clatworthy, Sergey Nejentsev, J. Nicole Hamblin, Edith M. Hessel, Alison M. Condliffe, Klaus Okkenhaug
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Antibody mediated immune responses to Streptococcus pneumoniae are crucial for the immune response to infection. Here the authors show hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-ind
Externí odkaz:
https://doaj.org/article/c9aa4017c3b04e369742fcdb03fa2a6c
Autor:
Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
Publikováno v:
Journal of medicinal chemistry. 64(18)
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonam
Autor:
Rainard Fuhr, L. Dunsire, Julie Nicole Hamblin, Anne Kirsten, Anthony Cahn, Claudia Leemereise, Henrik Watz, Edith M. Hessel, Srividya Sriskantharajah, L. Galinanes-Garcia, Robert Wilson, Mickael Montembault, Malcolm Begg
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 46:69-77
Background While current therapies reduce symptoms in chronic obstructive pulmonary disease (COPD) patients, substantial unmet need remains and novel treatments are highly desired. Phosphoinositide 3-kinase δ (PI3Kδ) is a lipid kinase specifically
Autor:
Alison M. Condliffe, Srividya Sriskantharajah, Rafeah Alam, Klaus Okkenhaug, Glyn Bradley, Krishnendu Chakraborty, Jonathan Clark, Valentina Carbonaro, Anita Chandra, Menna R. Clatworthy, Edward Banham-Hall, J. Nicole Hamblin, Sergey Nejentsev, Alex G. Richter, Edith M. Hessel, Anne-Katrien Stark
Streptococcus pneumoniaeis a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can offer protection against repeated exposure toS. pneumoniae, yet vaccines only offer partial protection. Patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250419a8fc282cee00248885c88c453f
Autor:
Thomas Southworth, Aoibheann F. Mullan, Antonia Banyard, Dave Singh, Vandana Gupta, Srividya Sriskantharajah
Publikováno v:
British Journal of Clinical Pharmacology. 79:767-776
Aims Lipopolysaccharide (LPS) inhalation causes increased airway and systemic inflammation. We investigated LPS inhalation in patients with chronic obstructive pulmonary disease (COPD) as a model of bacterial exacerbations. We studied safety, changes
Autor:
Srividya Sriskantharajah, Dave Singh, Thomas Southworth, Abid Khan, Edith M. Hessel, Augustin Amour, Sally Worsley
Publikováno v:
Clinical and experimental pharmacologyphysiology. 44(9)
Lymphocyte numbers are increased in the lungs of chronic obstructive pulmonary disease (COPD) patients. Phosphatidylinositol-3-kinase delta (PI3Kδ) is involved in lymphocyte activation. We investigated the effect of PI3Kδ inhibition on cytokine rel
Autor:
Eva Gückel, Mark S. Wilson, Stephanie Czieso, Isobel S. Okoye, Andrew S. MacDonald, Victoria S. Pelly, Yanda Li, Yashaswini Kannan, Stephanie M. Coomes, Nikolay Nikolov, Lauren M. Webb, Srividya Sriskantharajah, Steven C. Ley
Publikováno v:
Kannan, Y, Li, Y, Coomes, S M, Okoye, I S, Pelly, V, Sriskantharajah, S, Gückel, E, Webb, L, Czieso, S, Nikolov, N, MacDonald, A, Ley, S C & Wilson, M S 2017, ' Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells ', Journal of Allergy and Clinical Immunology, vol. 139, no. 2 . https://doi.org/10.1016/j.jaci.2016.05.031
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
BACKGROUND: The molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. Tumor progression locus 2 (TPL-2) (COT, MAP3K8) kinase activates the MEK1/2-extracellular-signal regulated kinase 1/2 MAP kinase signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bb032d36ffee65605f85a8574718ae
https://www.research.manchester.ac.uk/portal/en/publications/tumor-progression-locus-2-reduces-severe-allergic-airway-inflammation-by-inhibiting-ccl24-production-in-dendritic-cells(0a09f5db-2bf3-4f69-859a-08a968ec9c87).html
https://www.research.manchester.ac.uk/portal/en/publications/tumor-progression-locus-2-reduces-severe-allergic-airway-inflammation-by-inhibiting-ccl24-production-in-dendritic-cells(0a09f5db-2bf3-4f69-859a-08a968ec9c87).html
Autor:
George Kollias, Eva Gückel, Steven C. Ley, Marc Veldhoen, Katrin Kierdorf, Anne O'Garra, Abduelhakem Ben-Addi, Philip N. Tsichlis, Christine Brender, Marco Prinz, Brigitta Stockinger, Srividya Sriskantharajah, Niki Tsakiri
Publikováno v:
The Journal of Immunology; Vol 192
Tumor progression locus 2 (TPL-2) expression is required for efficient polarization of naive T cells to Th1 effector cells in vitro, as well as for Th1-mediated immune responses. In the present study, we investigated the potential role of TPL-2 in Th
Autor:
Andrew R. Calver, Edith M. Hessel, Augustin Amour, Sally Worsley, Nicole Hamblin, Srividya Sriskantharajah
Publikováno v:
Annals of the New York Academy of Sciences. 1280:35-39
Asthma and chronic obstructive pulmonary disease (COPD) are characterized in their pathogenesis by chronic inflammation in the airways. Phosphoinositide 3-kinase δ (PI3Kδ), a lipid kinase expressed predominantly in leukocytes, is thought to hold mu
Publikováno v:
Immunological Reviews. 246:168-182
Nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) activation play central roles in the induction of gene expression in innate immune cells following pathogen recognition. TPL-2 (tumor progression locus 2) is the MAP 3-kinase com