Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Srividya Balasubramanian"'
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Lysine-specific demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and repression of gene expression, depending upon context. KDM1A plays an important role in hematopoiesis and was identified as a dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa8a610fc2d1e8853a7290e6d74095e
https://doi.org/10.1158/0008-5472.c.6507927.v1
https://doi.org/10.1158/0008-5472.c.6507927.v1
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Includes Supplementary Methods, Supplementary Tables and Figures and References Supplementary Figure 1: Structure and enzyme inhibitory activity of the KDM1A tool compounds. Supplementary Figure 2: CETSA shows thermal stabilization of KDM1A in intact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad7b062c053bb3b56ba1bd985056d8
https://doi.org/10.1158/0008-5472.22410150
https://doi.org/10.1158/0008-5472.22410150
Autor:
Patrick Trojer, Barbara M. Bryant, Danette L. Daniels, David Stokoe, Steven Magnuson, Thomas O'Brien, Thomas M. Edwards, Charlie Hatton, Shilpi Arora, Shobu Odate, Srividya Balasubramanian, Kaylyn E. Williamson, John P. McGrath
Supplementary Table S1: Gene expression changes in Kasumi-1 and SKNO-1 cells upon treatment with RN-1, GSK690 and GSK690* for 24 and 72 hours compared to DMSO-treated controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86203d415f557a18d1d7d1c33c2e01b1
https://doi.org/10.1158/0008-5472.22410147.v1
https://doi.org/10.1158/0008-5472.22410147.v1
Autor:
Venita G. Watson, Richard T. Cummings, Victor S. Gehling, Andrew C. Good, Brian K. Albrecht, Priyanka Sawant, John P. McGrath, James E. Audia, Jean-Christophe Harmange, Priyadarshini Iyer, Rishi G. Vaswani, Srividya Balasubramanian, Alexandre Côté, Avinash Khanna, Steven Bellon, Francois Brucelle, Julian Levell, Patrick Trojer, Jacob I. Stuckey, Martin Duplessis
Publikováno v:
ACS Med Chem Lett
[Image: see text] Leveraging the catalytic machinery of LSD1 (KDM1A), a series of covalent styrenylcyclopropane LSD1 inhibitors were identified. These inhibitors represent a new class of mechanism-based inhibitors that target and covalently label the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8bd700da48c22429c52efbf950d81b
https://pubmed.ncbi.nlm.nih.gov/32551003
https://pubmed.ncbi.nlm.nih.gov/32551003
Autor:
Srividya Balasubramanian, Robert K. Campbell, Patrick Trojer, Christina O. Lee, Jon R. Wilson, Emmanuel Normant, Les A. Dakin, Martin Duplessis, Brian K. Albrecht, Jean-Christophe Harmange, Rishi G. Vaswani, James E. Audia, Priyadarshini Iyer, Andrew Simon Cook, Neil Justin, Steven J. Gamblin, Nico Cantone, Andrew C. Good, Feng Zhao, Richard T. Cummings, Steven F. Bellon, Christopher G. Nasveschuk, Shuyang Chen, Ying Zhang, Victor S. Gehling
Publikováno v:
Journal of Medicinal Chemistry. 59:9928-9941
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b439dd2f817b39a50f28ca2f51086f0
https://doi.org/10.1021/acs.jmedchem.6b01315
https://doi.org/10.1021/acs.jmedchem.6b01315
Autor:
Barbara M. Bryant, Patrick Trojer, Emmanuel Normant, Richard T. Cummings, Nico Cantone, Victor S. Gehling, William D. Bradley, Les A. Dakin, Rishi G. Vaswani, Chih-Chi Yuan, Kaylyn E. Williamson, Robert E. Campbell, Jean-Christophe Harmange, James E. Audia, Jacqui Méndez, Jennifer Busby, Christopher G. Nasveschuk, Feng Zhao, Danette L. Daniels, Brian K. Albrecht, Shivani Garapaty-Rao, Andrew S. Cook, Charlie Hatton, Srividya Balasubramanian, Shilpi Arora, Priyadarshini Iyer
Publikováno v:
Chemistry & Biology. 21(11):1463-1475
SummaryThe histone lysine methyltransferase (MT) Enhancer of Zeste Homolog 2 (EZH2) is considered an oncogenic driver in a subset of germinal center B-cell-like diffuse large B cell lymphoma (GCB-DLBCL) and follicular lymphoma due to the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46c41b4dade71656e822cd7aa8a7bb0
Autor:
Richard D. Cummings, Jennifer Busby, Alexandre Gagnon, Jean-Christophe Harmange, Christopher G. Nasveschuk, Eric Y. Chan, Srividya Balasubramanian, Patrick Trojer, Brian K. Albrecht, Peter Sandy, Shivani Garapaty-Rao, Robert M. Campbell, Louise Bergeron, Feng Zhao, James E. Audia
Publikováno v:
Chemistry & Biology. 20:1329-1339
SummaryThe histone methyltransferase enhancer of Zeste homolog 2 (EZH2) is a candidate oncogene due to its prevalent overexpression in malignant diseases, including late stage prostate and breast cancers. The dependency of cancer cells on EZH2 activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575a004730d4a63e4a0127ab5a46e524
https://doi.org/10.1016/j.chembiol.2013.09.013
https://doi.org/10.1016/j.chembiol.2013.09.013
Autor:
Deanna A. Mele, Robert J. Sims, Louise Bergeron, Jennifer A. Mertz, Srividya Balasubramanian, Peter Sandy, Andrew R. Conery, Barbara M. Bryant
Publikováno v:
Proceedings of the National Academy of Sciences. 108:16669-16674
The MYC transcription factor is a master regulator of diverse cellular functions and has been long considered a compelling therapeutic target because of its role in a range of human malignancies. However, pharmacologic inhibition of MYC function has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6342673556a3eb7f3e5882d367dce2
https://doi.org/10.1073/pnas.1108190108
https://doi.org/10.1073/pnas.1108190108
Autor:
Margaret A. Thompson, Yoojin Choi, Jennifer A. Chan, Rosalind A. Segal, Carolyn O Walsh, Maria F. Pazyra-Murphy, Srividya Balasubramanian, Rochelle M. Witt, Kellie J. Nazemi
Publikováno v:
Nature neuroscience
Sonic Hedgehog (Shh) has dual roles in vertebrate development, promoting progenitor cell proliferation and inducing tissue patterning. We found that the mitogenic and patterning functions of Shh can be uncoupled from one another. Using a genetic appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82374bc4058254f6476bbbeef2e38983
http://europepmc.org/articles/PMC2676236
http://europepmc.org/articles/PMC2676236
Autor:
David Stokoe, Kaylyn E. Williamson, Srividya Balasubramanian, Thomas O'Brien, Charlie Hatton, Steven Magnuson, Patrick Trojer, Shilpi Arora, Thomas M. Edwards, Barbara M. Bryant, Shobu Odate, John P. McGrath, Danette L. Daniels
Publikováno v:
Cancer research. 76(7)
Lysine-specific demethylase 1 (KDM1A) is a transcriptional coregulator that can function in both the activation and repression of gene expression, depending upon context. KDM1A plays an important role in hematopoiesis and was identified as a dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1746f97bb34dfd50a3fd37443829d81
https://pubmed.ncbi.nlm.nih.gov/26837761
https://pubmed.ncbi.nlm.nih.gov/26837761