Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Srividya, Neelakantan"'
Disease progression modeling of the North Star Ambulatory Assessment for Duchenne Muscular Dystrophy
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 375-386 (2023)
Abstract Duchenne muscular dystrophy (DMD) is a rare genetic disorder caused by decreased or absent dystrophin gene leading to progressive muscle degeneration and weakness in young boys. Disease progression models for the North Star Ambulatory Assess
Externí odkaz:
https://doaj.org/article/eec9b2ee80954fc29c1fa3a1f3337e51
Autor:
Xingpeng Li, Mary Lynn Baniecki, Maria Kłopocka, Uwe Schoenbeck, Christopher Lepsy, Zhan Ye, Craig L. Hyde, Michael S. Vincent, Ellen Scherl, Randy S. Longman, Mina Hassan-Zahraee, Srividya Neelakantan, Silvio Danese, Deepa E. Chandra, Jessica R. Allegretti, Jie Quan, Fridrik Karlsson, Nancy Raha, Jacek Romatowski, Li Xi, Kenneth E. Hung, Daniel Ziemek, Jenny Zhang
Publikováno v:
Inflammatory Bowel Diseases. 28:434-446
Background The first-in-class treatment PF-06480605 targets the tumor necrosis factor-like ligand 1A (TL1A) molecule in humans. Results from the phase 2a TUSCANY trial highlighted the safety and efficacy of PF-06480605 in ulcerative colitis. Preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e98bcf6a53549f7ab72476adb6edbc5
https://doi.org/10.1093/ibd/izab193
https://doi.org/10.1093/ibd/izab193
Publikováno v:
Journal of Scientific Dentistry. 11:16-18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478aab3947e229a11c4294bcf1d9b4b4
https://doi.org/10.5005/jp-journals-10083-0941
https://doi.org/10.5005/jp-journals-10083-0941
Autor:
Mina Hassan-Zahraee, Srividya Neelakantan, Kenneth E. Hung, Christopher Banfield, Silvio Danese, J Romatowski, Li Xi, Elena Peeva, Zhan Ye, Ellen Scherl, Christopher Lepsy, Deepa E. Chandra, Maria Kłopocka, Gang Li, Uwe Schoenbeck, Natalie Rath, Michael S. Vincent, Jessica R. Allegretti
Publikováno v:
Journal of Crohn's and Colitis. 14:S108-S110
Background Widespread disruption of the mucosal immune system is central to the pathogenesis of ulcerative colitis (UC). One component, tumour necrosis factor (TNF) α-like ligand 1A (TL1A), is upregulated at the site of active disease in UC. Treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d331153012ebf942fc8c0f37f55b2b
https://doi.org/10.1093/ecco-jcc/jjz203.111
https://doi.org/10.1093/ecco-jcc/jjz203.111
Autor:
Christopher Lepsy, Jacek Romatowski, Maria Kłopocka, Mina Hassan-Zahraee, Ellen Scherl, Silvio Danese, Natalie Rath, Jessica R. Allegretti, Kenneth E. Hung, Deepa E. Chandra, Uwe Schoenbeck, Zhan Ye, Christopher Banfield, Gang Li, Srividya Neelakantan, Elena Peeva, Michael S. Vincent
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 19(11)
Background & Aims An immune component of inflammatory bowel disease is up-regulated tumor necrosis factor-like ligand 1A (TL1A). Anti-TL1A antibodies such as PF-06480605, a fully human immunoglobulin G1 monoclonal antibody, may have therapeutic poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66a93080729d60e564b71e5eb0a951a
https://pubmed.ncbi.nlm.nih.gov/34126262
https://pubmed.ncbi.nlm.nih.gov/34126262
Autor:
Vahid Farrokhi, Hendrik Neubert, Pinky Dua, Florence H. Yong, Teresa M Caiazzo, Srividya Neelakantan, Jane Owens, Michael Binks, Caroline Le Guiner, Jason Walsh, Joanne Brodfuehrer, Joe Palandra
Publikováno v:
Gene therapy. 29(10-11)
Duchenne muscular dystrophy (DMD) is a lethal, degenerative muscle disorder caused by mutations in the DMD gene, leading to severe reduction or absence of the protein dystrophin. Gene therapy strategies that aim to increase expression of a functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ab2bb4b6587fcf44028ba1df34b0bc
https://pubmed.ncbi.nlm.nih.gov/34737451
https://pubmed.ncbi.nlm.nih.gov/34737451
Publikováno v:
Journal of clinical pharmacologyReferences. 61(7)
Recombinant factor VIII Fc fusion protein (rFVIIIFc) has been indicated for adults and children with hemophilia A. The objective of this article was to build a population pharmacokinetic (PK) model using adult and pediatric data sets and explore rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132f1f0762ab5b55a01386e4833f28d2
https://pubmed.ncbi.nlm.nih.gov/33719084
https://pubmed.ncbi.nlm.nih.gov/33719084
Autor:
Barry Oemar, Gabe Berman, Lori Ann Cox, Natalie Rath, Kathleen Pelletier, Mikhail Salganik, Sanela Tarabar, Kristen Johnson, Karen Page, Srividya Neelakantan, Dean Messing
Publikováno v:
Clinical pharmacology in drug developmentReferences. 10(3)
This double-blind, randomized, placebo-controlled, dose-ascending, first-in-human study (NCT02766621) assessed the safety, tolerability, and pharmacokinetics (PK) of PF-06823859, an anti-interferon β monoclonal antibody. Healthy subjects were random
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee3d55d275c5bebea170466bf27d24b
https://pubmed.ncbi.nlm.nih.gov/33352008
https://pubmed.ncbi.nlm.nih.gov/33352008
Autor:
Michio Sakai, Katsuyuki Fukutake, Masashi Taki, Glenn F. Pierce, Tadashi Matsushita, Baisong Mei, Yingwen Dong, Srividya Neelakantan, Lynda M. Cristiano, Keiji Nogami, Midori Shima, Hideji Hanabusa
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 27:665-677
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d133da7f79c6eb574137c2d8e1d5ecd
https://doi.org/10.2491/jjsth.27.665
https://doi.org/10.2491/jjsth.27.665
Autor:
Christopher Lepsy, Elena Peeva, Christopher Banfield, Natalie Rath, Deepa E. Chandra, Jessica R. Allegretti, Jacek Romatowski, Kenneth E. Hung, Srividya Neelakantan, Ellen Scherl, Uwe Schoenbeck, Maria Kłopocka, Mina Hassan-Zahraee, Michael S. Vincent, Silvio Danese, Zhan Ye, Gang Li, Li Xi
Publikováno v:
Gastroenterology. 158:S-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf7534c7c9301b6f03d7213a04884c72
https://doi.org/10.1016/s0016-5085(20)31203-8
https://doi.org/10.1016/s0016-5085(20)31203-8