Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Srividhya Iyer"'
Autor:
Filipa Ponte, Ha-Neui Kim, Aaron Warren, Srividhya Iyer, Li Han, Erin Mannen, Horacio Gomez-Acevedo, Intawat Nookaew, Maria Almeida, Stavros C. Manolagas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge. We report that the matrix metall
Externí odkaz:
https://doaj.org/article/efdc91c3db6e4638a849c4d127d65410
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) t
Externí odkaz:
https://doaj.org/article/a54a3d70b3254f2d8cfecbddf28dceb2
Autor:
Srividhya Iyer, Christian Melendez‐Suchi, Li Han, Giulia Baldini, Maria Almeida, Robert L. Jilka
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 4, Pp 207-218 (2020)
Abstract Increased production of the osteoclastogenic cytokine RANKL is a common feature of pathologic bone loss, but the underlying cause of this increase is poorly understood. The unfolded protein response (UPR) is activated in response to accumula
Externí odkaz:
https://doaj.org/article/5cb1f287abc348089efda90356d74c39
Autor:
Samantha H. Landgrave, Toru Ishii, Robert Maynard, Andrew Wu, Dana Godfrey, Terrin Manes, Veronica Butler, David Villani, Honey Hendesi, Rachel Frank, Srividhya Iyer, Karin Payne, Douglas J. Adams, Lacey Favazzo, Beate Lanske, Michael J. Zuscik
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 53-53 (2022)
OBJECTIVES/GOALS: Osteoarthritis (OA) is a cartilage destroying disease. We are investigating abaloparatide (ABL) activation of parathyroid hormone receptor type 1 (PTH1R), which is expressed by articular chondrocytes in OA. We propose ABL treatment
Externí odkaz:
https://doaj.org/article/eae651ba28a74f96a5f4c54514534c22
Autor:
Ha-Neui Kim, Jinhu Xiong, Ryan S. MacLeod, Srividhya Iyer, Yuko Fujiwara, Keisha M. Cawley, Li Han, Yonghan He, Jeff D. Thostenson, Elisabeth Ferreira, Robert L. Jilka, Daohong Zhou, Maria Almeida, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod
Externí odkaz:
https://doaj.org/article/657c52f5dd0742dba28700a3da2de806
Autor:
Srividhya Iyer, Douglas J. Adams
Publikováno v:
Calcified Tissue International.
Differentiation and optimal function of osteoblasts and osteoclasts are contingent on synthesis and maintenance of a healthy proteome. Impaired and/or altered secretory capacity of these skeletal cells is a primary driver of most skeletal diseases. T
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-11 (2021)
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease
Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) transcript
Autor:
Filipa Ponte, Ha-Neui Kim, Aaron Warren, Srividhya Iyer, Li Han, Erin Mannen, Horacio Gomez-Acevedo, Intawat Nookaew, Maria Almeida, Stavros C. Manolagas
The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge. We report that the matrix metalloproteina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503870e0ce33cecb41179692d2822225
https://doi.org/10.21203/rs.3.rs-1431477/v1
https://doi.org/10.21203/rs.3.rs-1431477/v1
Autor:
G. Srividhya Iyer
We live in the age where research on time travel is being carried out. The world has seen the famous mathematician Mrs. Shakunthala Devi who is popularly known as the human computer. Currently the world is witnessing a machine being conferred with ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee5ff087ec20747e2d225e3ed6b6de2
Autor:
G. Srividhya Iyer
In the 21st Century in the world of computers everything is digitalized. This is an era of smart phones, smart classes and smart contracts. The world is being held in our palms. Contracts are being entered into across the globe day in a day out. Smar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96612b8f27222c3babaa8c679e707456