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Rationally Designed G-Quadruplex Selective "Turn-On" NIR Fluorescent Probe with Large Stokes Shift for Nucleic Acid Research-Based Applications.

Autor: Parveen S; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Chaurasia N; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Gupta S; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India., Vidyarthi S; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Gupta N; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Pandey P; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India., Pant B; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Srivastava KR; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Kumar N; Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India., Goel A; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.; Academy of Scientific and Innovative Research, Ghaziabad 201002, India.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2024 Nov 18; Vol. 7 (11), pp. 7233-7243. Date of Electronic Publication: 2024 Oct 28.

Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis.

Autor: Abhishek Shah A; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India., Chand D; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Ahamad S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India., Porwal K; Division of Endocrinology and Center for Research on Anabolic Skeletal Targets for Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226031, India., Chourasia MK; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mohanan K; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Srivastava KR; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: kinshuk.srivastava@cdri.res.in., Chattopadhyay N; Division of Endocrinology and Center for Research on Anabolic Skeletal Targets for Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: n_chattopadhyay@cdri.res.in.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct 22; Vol. 230 (Pt 2), pp. 116587. Date of Electronic Publication: 2024 Oct 22.

Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists.

Autor: Kumar S; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Rastogi SK; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Roy S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India., Sharma K; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Kumar S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Maity D; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Chand D; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Vishwakarma S; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Gayen JR; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Srivastava KR; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Kumar R; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India. Electronic address: ravindra.kumar1@cdri.res.in., Yadav PN; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India. Electronic address: pn.yadav@cdri.res.in.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Sep 07; Vol. 153, pp. 107809. Date of Electronic Publication: 2024 Sep 07.

Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations.

Autor: Werren EA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Advanced Precision Medicine Laboratory, The Jackson Laboratory for Genomic Medicine, Farmington, CTt, 06032, USA., Peirent ER; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA., Jantti H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Guxholli A; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Srivastava KR; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India., Orenstein N; Schneider Children's Medical Center of Israel, Petah Tikva, 4920235, Israel., Narayanan V; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Wiszniewski W; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA., Dawidziuk M; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Gawlinski P; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Umair M; Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, 11481, Saudi Arabia.; Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Punjab, 54770, Pakistan., Khan A; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA.; Department of Zoology, University of Lakki Marwat, Lakki Marwat, Khyber Pakhtunkhwa, 28420, Pakistan., Khan SN; Department of Zoology, Kohat University of Science and Technology, Kohat, Pakistan., Geneviève D; Montpellier University, Inserm Unit U1183, Reference Center for Rare Diseases and Developmental Anomalies, CHU, 34000, Montpellier, France., Lehalle D; Sorbonne University, Department of Medical Genetics, Hospital Armand Trousseau, 75012, Paris, France., van Gassen KLI; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Giltay JC; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Oegema R; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., van Jaarsveld RH; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Rafiullah R; Department of Biotechnology, Faculty of Life Sciences, BUITEMS, Quetta, 87300, Pakistan., Rappold GA; Department of Human Molecular Genetics, Institute of Human Genetics, Ruprecht-Karls-University, Heidelberg, 69120, Germany., Rabin R; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, 10016, USA., Pappas JG; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, 10016, USA., Wheeler MM; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA., Bamshad MJ; Department of Pediatrics, University of Washington, Seattle, WA, 98195, USA.; Brotman Baty Institute, Washington, 98195, USA., Tsan YC; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Johnson MB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Keegan CE; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Srivastava A; Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India. asrivastavapgi@gmail.com., Bielas SL; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. sbielas@umich.edu.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. sbielas@umich.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 May 30; Vol. 15 (5), pp. 379. Date of Electronic Publication: 2024 May 30.