Design of a Zinc-Finger Hydrolase with a Synthetic alpha beta beta Protein

Autor: SRIVASTAVA, KR, DURANI, S

Publikováno v: IndraStra Global.

Recent advances in protein design have opened avenues for the creation of artificial enzymes needed for biotechnological and pharmaceutical applications. However, designing efficient enzymes remains an unrealized ambition, as the design must incorpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=issn23813652::4479607c73858ae7aca1e781e1bb4294
http://dspace.library.iitb.ac.in/jspui/handle/100/17311

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Therapeutic targeting of Wnt antagonists by small molecules for treatment of osteoporosis.

Autor: Abhishek Shah A; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India., Chand D; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Ahamad S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India., Porwal K; Division of Endocrinology and Center for Research on Anabolic Skeletal Targets for Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226031, India., Chourasia MK; Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Mohanan K; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Srivastava KR; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: kinshuk.srivastava@cdri.res.in., Chattopadhyay N; Division of Endocrinology and Center for Research on Anabolic Skeletal Targets for Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: n_chattopadhyay@cdri.res.in.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct 22; Vol. 230 (Pt 2), pp. 116587. Date of Electronic Publication: 2024 Oct 22.

Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists.

Autor: Kumar S; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Rastogi SK; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Roy S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India., Sharma K; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Kumar S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Maity D; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Chand D; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Vishwakarma S; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Gayen JR; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India; Pharmaceutics & Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, U.P., (226031), India., Srivastava KR; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India., Kumar R; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India. Electronic address: ravindra.kumar1@cdri.res.in., Yadav PN; Neuroscience and Ageing Biology Division, CSIR-Central Drug Research Institute, Lucknow, U.P., (226031), India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P., (201002), India. Electronic address: pn.yadav@cdri.res.in.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Sep 07; Vol. 153, pp. 107809. Date of Electronic Publication: 2024 Sep 07.

Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations.

Autor: Werren EA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Advanced Precision Medicine Laboratory, The Jackson Laboratory for Genomic Medicine, Farmington, CTt, 06032, USA., Peirent ER; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA., Jantti H; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Guxholli A; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Srivastava KR; Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India., Orenstein N; Schneider Children's Medical Center of Israel, Petah Tikva, 4920235, Israel., Narayanan V; Center for Rare Childhood Disorders, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Wiszniewski W; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA., Dawidziuk M; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Gawlinski P; Department of Medical Genetics, Institute of Mother and Child, Warsaw, 01-211, Poland., Umair M; Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, 11481, Saudi Arabia.; Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Punjab, 54770, Pakistan., Khan A; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA.; Department of Zoology, University of Lakki Marwat, Lakki Marwat, Khyber Pakhtunkhwa, 28420, Pakistan., Khan SN; Department of Zoology, Kohat University of Science and Technology, Kohat, Pakistan., Geneviève D; Montpellier University, Inserm Unit U1183, Reference Center for Rare Diseases and Developmental Anomalies, CHU, 34000, Montpellier, France., Lehalle D; Sorbonne University, Department of Medical Genetics, Hospital Armand Trousseau, 75012, Paris, France., van Gassen KLI; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Giltay JC; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Oegema R; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., van Jaarsveld RH; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 EA, The Netherlands., Rafiullah R; Department of Biotechnology, Faculty of Life Sciences, BUITEMS, Quetta, 87300, Pakistan., Rappold GA; Department of Human Molecular Genetics, Institute of Human Genetics, Ruprecht-Karls-University, Heidelberg, 69120, Germany., Rabin R; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, 10016, USA., Pappas JG; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, 10016, USA., Wheeler MM; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA., Bamshad MJ; Department of Pediatrics, University of Washington, Seattle, WA, 98195, USA.; Brotman Baty Institute, Washington, 98195, USA., Tsan YC; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Johnson MB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Keegan CE; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Srivastava A; Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India. asrivastavapgi@gmail.com., Bielas SL; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. sbielas@umich.edu.; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. sbielas@umich.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2024 May 30; Vol. 15 (5), pp. 379. Date of Electronic Publication: 2024 May 30.