Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sriram Aravamudhan"'
Autor:
Theresa Bock, Clara Türk, Sriram Aravamudhan, Lena Keufgens, Wilhelm Bloch, Dieu Hien Rozsivalova, Vanina Romanello, Leonardo Nogara, Bert Blaauw, Aleksandra Trifunovic, Thomas Braun, Marcus Krüger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B, s
Externí odkaz:
https://doaj.org/article/388735121d3e40b9adaa050527702242
Autor:
Franziska Lang, Sriram Aravamudhan, Hendrik Nolte, Clara Türk, Soraya Hölper, Stefan Müller, Stefan Günther, Bert Blaauw, Thomas Braun, Marcus Krüger
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 881-896 (2017)
Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spec
Externí odkaz:
https://doaj.org/article/d21884356e0f497c8ab97e2ecf126f94
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73998 (2013)
Neutrophil granulocytes are pivotal cells within the first line of host defense of the innate immune system. In this study, we have used a gel-based LC-MS/MS approach to explore the proteome of primary marrow neutrophils from adult zebrafish. The ide
Externí odkaz:
https://doaj.org/article/a2c74f3aba704cab872d32d89976d72f
Autor:
Vanina Romanello, Thomas Braun, Clara Türk, Bert Blaauw, Dieu Hien Rozsivalova, Lena Keufgens, Wilhelm Bloch, Marcus Krüger, Aleksandra Trifunovic, Leonardo Nogara, Theresa Bock, Sriram Aravamudhan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood.
Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein
Autor:
Thomas Braun, Theresa Bock, Susanne Brodesser, Philipp Hammerschmidt, Sriram Aravamudhan, Tim König, Ramesh K. Krishnan, Dieu Hien Rozsivalova, Franziska Lang, Marcus Krüger, Clara Türk, Aleksandra Trifunovic, Jens C. Brüning, Lena Keufgens, Natalie Schindler, Elena I. Rugarli, Thomas Langer, Hendrik Nolte
Publikováno v:
J Mol Cell Cardiol
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,
Autor:
Bert Blaauw, Stefan Müller, Sriram Aravamudhan, Hendrik Nolte, Franziska Lang, Marcus Krüger, Stefan Günther, Thomas Braun, Soraya Hölper, Clara Türk
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 7, Pp 881-896 (2017)
Disease Models & Mechanisms
Disease Models & Mechanisms
Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spec
Autor:
Manuel Mayr, Alexandra J. Candasamy, Cesare M. Terracciano, Sriram Aravamudhan, Mark R. Holt, Michael Ibrahim, Mathias Gautel, Robert S. Haworth, Metin Avkiran, Friederike Cuello, Marcus Krüger
Publikováno v:
The Journal of Biological Chemistry
Candasamy, A J, Haworth, R S, Cuello, F, Ibrahim, M, Aravamudhan, S, Krueger, M, Holt, M R, Terracciano, C M N, Mayr, M, Gautel, M & Avkiran, M 2014, ' Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes ', Journal of Biological Chemistry, vol. 289, no. 3, pp. 1282-1293 . https://doi.org/10.1074/jbc.M113.479030
Candasamy, A J, Haworth, R S, Cuello, F, Ibrahim, M, Aravamudhan, S, Krueger, M, Holt, M R, Terracciano, C M N, Mayr, M, Gautel, M & Avkiran, M 2014, ' Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes ', Journal of Biological Chemistry, vol. 289, no. 3, pp. 1282-1293 . https://doi.org/10.1074/jbc.M113.479030
Background: Telethonin mutations are associated with cardiomyopathy through unknown mechanisms. Results: Telethonin is a substrate for CaMK family kinases and exists in a bis-phosphorylated state in cardiomyocytes, in which non-phosphorylated teletho
Autor:
Priyanka Kohli, Bernard R. Brooks, Markus M. Rinschen, Marcus Krüger, Xiongwu Wu, Puneet Bharill, Matthäus J. Reinert, Isabel Saez, Martin Höhne, Oliver Kretz, Bernhard Schermer, Roman-Ulrich Müller, Thomas Benzing, Malte P. Bartram, Tobias B. Huber, Sriram Aravamudhan, David Vilchez
Publikováno v:
Rinschen, M M, Bharill, P, Wu, X, Kohli, P, Reinert, M J, Kretz, O, Saez, I, Schermer, B, Höhne, M, Bartram, M P, Aravamudhan, S, Brooks, B R, Vilchez, D, Huber, T B, Müller, R U, Krüger, M & Benzing, T 2016, ' The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes ', Human Molecular Genetics, vol. 25, no. 7, ddw016, pp. 1328-1344 . https://doi.org/10.1093/hmg/ddw016
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4580de14010ac6431363a5f34977dc3a
https://pure.au.dk/portal/da/publications/the-ubiquitin-ligase-ubr4-controls-stability-of-podocinmec2-supercomplexes(7576f44b-d303-4119-b1e2-b45520303e66).html
https://pure.au.dk/portal/da/publications/the-ubiquitin-ligase-ubr4-controls-stability-of-podocinmec2-supercomplexes(7576f44b-d303-4119-b1e2-b45520303e66).html
Publikováno v:
Fishshellfish immunology. 40(1)
Neutrophils are the most abundant polymorphonuclear leukocytes, presenting the first line of defence against infection or tissue damage. To characterize the molecular changes on the protein level in neutrophils during sterile inflammation we establis
Publikováno v:
Journal of Magnetic Resonance
By increasing the pulse rate in WHH-type multiple-pulse sequences we have succeeded in qualitatively improving the resolution in high-resolution proton magnetic resonance (PMR) spectroscopy in solids. WHH-type sequences are characterized by pulse spa