Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Sriram, Neelamegham"'
Autor:
Yayu Liu, Pedro Lei, Ronel Z. Samuel, Anagha M. Kashyap, Theodore Groth, Wiam Bshara, Sriram Neelamegham, Stelios T. Andreadis
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2056-2073 (2023)
During epithelial–mesenchymal transition (EMT) in cancer progression, tumor cells switch cadherin profile from E‐cadherin to cadherin‐11 (CDH11), which is accompanied by increased invasiveness and metastatic activity. However, the mechanism thr
Externí odkaz:
https://doaj.org/article/61a8c0a37da6437793ec0e2602e16bc1
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1712-1724 (2021)
Glycosylation is a common posttranslational modification, and glycan biosynthesis is regulated by a set of glycogenes. The role of transcription factors (TFs) in regulating the glycogenes and related glycosylation pathways is largely unknown. In this
Externí odkaz:
https://doaj.org/article/1c56f9f0067d441eb6e5e04a676fb922
Autor:
Benjamin P. Kellman, Yujie Zhang, Emma Logomasini, Eric Meinhardt, Karla P. Godinez-Macias, Austin W. T. Chiang, James T. Sorrentino, Chenguang Liang, Bokan Bao, Yusen Zhou, Sachiko Akase, Isami Sogabe, Thukaa Kouka, Elizabeth A. Winzeler, Iain B. H. Wilson, Matthew P. Campbell, Sriram Neelamegham, Frederick J. Krambeck, Kiyoko F. Aoki-Kinoshita, Nathan E. Lewis
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2645-2662 (2020)
Systems glycobiology aims to provide models and analysis tools that account for the biosynthesis, regulation, and interactions with glycoconjugates. To facilitate these methods, there is a need for a clear glycan representation accessible to both com
Externí odkaz:
https://doaj.org/article/d2673eab9e7b4440a013dfc392b24604
Autor:
Zhaowei Chen, Jiankai Lu, Changjie Zhang, Isaac Hsia, Xinheng Yu, Leo Marecki, Eric Marecki, Mohammadnabi Asmani, Shilpa Jain, Sriram Neelamegham, Ruogang Zhao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Blood clotting is a complex process involving platelet adhesion and clot stiffening. Here the authors present a microfluidic system to recapitulate the dynamic changes in clot mechanics under physiological shear.
Externí odkaz:
https://doaj.org/article/7a3a33d9afd740029c0735340ec2278f
Autor:
Sunanda Kumar, Dawei Jiang, Boyang Sun, Kaelyn V. Seeley, Jonathan W. Engle, Zachary Sia, Xuedan He, Sriram Neelamegham, Weibo Cai, Jonathan F. Lovell
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 1, Pp n/a-n/a (2021)
A method is developed for membrane labeling of erythrocytes with porphyrin‐phospholipid (PoP). To generate a concentrated PoP solution for labeling human red blood cells (RBCs), various surfactants and solvents are screened to identify conditions t
Externí odkaz:
https://doaj.org/article/8dd28602128c4b629d8c2367071a11bb
Publikováno v:
Glycobiology. 33:99-103
Nonulosonic acids or non-2-ulosonic acids (NulOs) are an ancient family of 2-ketoaldonic acids (α-ketoaldonic acids) with a 9-carbon backbone. In nature, these monosaccharides occur either in a 3-deoxy form (referred to as “sialic acids”) or in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::094474051ed295069c28320c8f2a7d13
https://doi.org/10.1093/glycob/cwac072
https://doi.org/10.1093/glycob/cwac072
Autor:
Qi Yang, Thomas A Hughes, Anju Kelkar, Xinheng Yu, Kai Cheng, Sheldon Park, Wei-Chiao Huang, Jonathan F Lovell, Sriram Neelamegham
Publikováno v:
eLife, Vol 9 (2020)
The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished. We expressed different glycoforms
Externí odkaz:
https://doaj.org/article/06cab1d1207041ffa2c5904dd82958ee
Publikováno v:
Molecules, Vol 26, Iss 19, p 5950 (2021)
Glycans have been shown to play a key role in many biological processes, such as signal transduction, immunogenicity, and disease progression. Among the various glycosylation modifications found on cell surfaces and in biomolecules, sialylation is es
Externí odkaz:
https://doaj.org/article/3c32069573ba4475921954d58c784f28
Autor:
Shobhit Gogia, Anju Kelkar, Changjie Zhang, Kannayakanahalli M. Dayananda, Sriram Neelamegham
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2063-2074 (2017)
Abstract: von Willebrand factor (VWF) and the metalloprotease a disintegrin and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) are present both within endothelial cells (ECs) and in peripheral blood. Calcium concentrations are lower i
Externí odkaz:
https://doaj.org/article/cf7795ed5a274442be538de4846616f5
Autor:
Changjie Zhang, Sriram Neelamegham
Publikováno v:
Platelets, Vol 28, Iss 5, Pp 434-440 (2017)
Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses
Externí odkaz:
https://doaj.org/article/90a87ecd6f0e43e1aa3930d265d0bac6