Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Srirajan Vaidyanathan"'
Autor:
Marc B. Skaddan, Dustin W. Wooten, Kyle C. Wilcox, Martin J. Voorbach, David R. Reuter, Zhaozhong J. Jia, Kelly D. Foster-Duke, Jonathan A. Hickson, Srirajan Vaidyanathan, Aimee D. Reed, Ann E. Tovcimak, Qi Guo, Robert A. Comley, Lance Lee, Sjoerd J. Finnema, Sarah R. Mudd
Publikováno v:
Molecular Imaging and Biology. 24:830-841
Autor:
Paul Tempest, Chin‐Yin Tai, Maiko Ono, Marc B Skaddan, Kyle C Wilcox, Aimee Reed, Srirajan Vaidyanathan, Claus T Christoffersen, Pekka Kallunki, Benny Bang‐Andersen, Richard A Margolin, Tzu‐Huei Kao, Makoto Higuchi, Ming‐Kuei Jang
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Srirajan Vaidyanathan, Aimee Reed
Publikováno v:
ACS medicinal chemistry letters. 13(10)
The long-lived radionuclides tritium and carbon-14 have been used for many years in pharmaceutical research and development for making key efficacy and toxicological decisions. Early discovery utilizes radiolabels for compound selection through radio
Publikováno v:
Journal of labelled compoundsradiopharmaceuticalsREFERENCES. 64(9)
Veliparib, a potent PARP inhibitor used against multiple cancerous cells such as metastatic melanoma, breast, non-small cell lung cancer (NSCLC) and prostatic cancer, is required for absorption, distribution, metabolism and excretion (ADME) and envir
Autor:
Srirajan Vaidyanathan, Hong Liu, Martin Dunbar, Anthony J. Lee, Ahmed Salem, Katty Wan, Sonia Maria de Morais, Shekman Wong, Melissa J. Michmerhuizen, Jens Sydor, Michael Serby, James Sawicki, Suresh Agarwal, Yanbin Lao
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(3)
Venetoclax (ABT-199), a B-cell lymphoma-2 (Bcl-2) protein inhibitor, is currently in clinical development for the treatment of hematologic malignancies. We characterized the absorption, metabolism, and excretion of venetoclax in humans. After a singl
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:166-170
β-amino acids 1 and 2 are α2δ agonists, which were developed for the treatment of generalized anxiety disorder and insomnia. The stable and radioactive isotope-labeled β-amino acids were required to support pre-clinical and clinical studies. Asym
Autor:
Arturo Perez-Medrano, William A. Carroll, Diana L. Donnelly-Roberts, Srirajan Vaidyanathan, Bruce Surber, Michael F. Jarvis, Marian T. Namovic, Ying Wang
Publikováno v:
Neuropharmacology. 56:223-229
ATP-sensitive P2X7 receptors are localized on cells of immunological origin including peripheral macrophages and glial cells in the CNS. Activation of P2X7 receptors leads to rapid changes in intracellular calcium concentrations, release of the pro-i
Autor:
Srirajan Vaidyanathan, Bruce W. Surber
Publikováno v:
Tetrahedron Letters. 46:5195-5197
Deuterium aromatic substituted compounds were prepared by microwave irradiation of the parent unlabeled compounds in the presence of deuterium oxide and deuterium chloride. The percentage of deuterium incorporation was investigated under various reac
Autor:
Robert B. Moreland, Srirajan Vaidyanathan, Bruce W. Surber, Rachid El Kouhen, Bruce R. Bianchi, Shirish N. Raja, Chih-Hung Lee, Pamela S. Puttfarcken, Connie R. Faltynek
Publikováno v:
The FASEB Journal. 20
Autor:
Bose, Ajay K., Ganguly, Subhendu N., Manhas, Maghar S., Srirajan, Vaidyanathan, Bhattacharjee, Ashoke, Rumthao, Sochanchingwung, Sharma, Anju H.
Publikováno v:
In Tetrahedron Letters 2 February 2004 45(6):1179-1181