Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sriraghavan, Kamaraj"'
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
Autor:
Nada Abla, Yuxiang Dong, Daniel Hunziker, Jörg J. Möhrle, André Alker, Jenna McLaren, Hugues Matile, Jonathan L. Vennerstrom, Kasiram Katneni, Christian Scheurer, Susan A. Charman, Sriraghavan Kamaraj, Scott Blundell, Xiaofang Wang, Sergio Wittlin, Lin Zhou, Francis C. K. Chiu, David M. Shackleford, Qingjie Zhao
Publikováno v:
ACS Infect Dis
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS, chemical derivatization, and metabolite synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3be4a450af4d05a8bd5e3a45a546d15
https://doi.org/10.1021/acsinfecdis.1c00225
https://doi.org/10.1021/acsinfecdis.1c00225
Autor:
Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2011 Mar . 108(11), 4400-4405.
Externí odkaz:
https://www.jstor.org/stable/41061126
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Francis C. K. Chiu, David M. Shackleford, Jianbo Wu, Karen L. White, Paul H. Davis, Alexander I. Wallick, Yuxiang Dong, Eileen Ryan, Jonathan L. Vennerstrom, Sriraghavan Kamaraj, Cécile Häberli, Susan A. Charman, Jennifer Keiser, Vivek J. Bulbule, Xiaofang Wang
Publikováno v:
J Med Chem
Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another hemoglobin-degrading pathogen. Building on this discovery, we now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e45a723a4bfa09fada381455c6650b9
https://europepmc.org/articles/PMC7182039/
https://europepmc.org/articles/PMC7182039/
Autor:
Yuxiang Dong, Sonawane, Yogesh, Maher, Steven P., Zeeman, Anne-Marie, Chaumeau, Victor, Vantaux, Amélie, Cooper, Caitlin A., Chiu, Francis C. K., Ryan, Eileen, McLaren, Jenna, Chen Gong, Wittlin, Sergio, Witkowski, Benoît, Nosten, François, Sriraghavan, Kamaraj, Kyle, Dennis E., Kocken, Clemens H. M., Charman, Susan A., Vennerstrom, Jonathan L.
Publikováno v:
ACS Omega; 4/12/2022, Vol. 7 Issue 14, p12401-12411, 11p
Autor:
Francis C. K. Chiu, David M. Shackleford, Karen L. White, Sergio Wittlin, Sriraghavan Kamaraj, Qingjie Zhao, Petros Papastogiannidis, Jonathan L. Vennerstrom, Eileen Ryan, Heinrich Urwyler, Christian Scheurer, Christopher D. Hein, Manickam Dhanasekaran, Vivek J. Bulbule, Lin Zhou, Helena Barker, Yuxiang Dong, Julia Morizzi, Susan A. Charman, Jacques Chollet, Xiaofang Wang, William N. Charman, Hugues Matile, Yuanqing Tang
Publikováno v:
Journal of Medicinal Chemistry. 60:2654-2668
Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure–activity relationship (SAR) of the antimalarial ozonide artefenomel (OZ439). Primary and secondary amino ozonides had highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5d0e4db318313ac45676fe7371d64d
https://doi.org/10.1021/acs.jmedchem.6b01586
https://doi.org/10.1021/acs.jmedchem.6b01586
Autor:
Sriraghavan Kamaraj, K. Chandrasekara Pillai, Annamalai Senthil Kumar, Nandimalla Vishnu, Ranganathan Shanmugam
Publikováno v:
Journal of Electroanalytical Chemistry. 782:215-224
Ellagic acid (EA) is a lactone and polyphenolic functional groups-containing phyto-chemical that has been widely used as an anti-oxidant, anti-cancer and anti-aging cosmetic agent. EA is known as a stable redox active system only in organic medium, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49c4957a2916350712030da8b2b7635
https://doi.org/10.1016/j.jelechem.2016.10.010
https://doi.org/10.1016/j.jelechem.2016.10.010
Publikováno v:
In Tetrahedron 2003 59(10):1791-1796