Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Sripad Ram"'
Autor:
Sripad Ram, Sepideh Mojtahedzadeh, Joan-Kristel Aguilar, Timothy Coskran, Eric L. Powell, Shawn P. O’Neil
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract We present a rigorous validation strategy to evaluate the performance of Ultivue multiplex immunofluorescence panels. We have quantified the accuracy and precision of four different multiplex panels (three human and one mouse) in tumor speci
Externí odkaz:
https://doaj.org/article/77deb466dce447ac8adccfed7c31650a
Autor:
Yeon Hee Park, Seock-Ah Im, Kyunghee Park, Ji Wen, Kyung-Hun Lee, Yoon-La Choi, Won-Chul Lee, Ahrum Min, Vinicius Bonato, Seri Park, Sripad Ram, Dae-Won Lee, Ji-Yeon Kim, Su Kyeong Lee, Won-Woo Lee, Jisook Lee, Miso Kim, Hyun Seon Kim, Scott L. Weinrich, Han Suk Ryu, Tae Yong Kim, Stephen Dann, Yu-Jin Kim, Diane R. Fernandez, Jiwon Koh, Shuoguo Wang, Song Yi Park, Shibing Deng, Eric Powell, Rupesh Kanchi Ravi, Jadwiga Bienkowska, Paul A. Rejto, Woong-Yang Park, Zhengyan Kan
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine therapy (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast cancer (HR+/HER2− MBC
Externí odkaz:
https://doaj.org/article/e43bea5e36154033b3975c0ba6d40d38
Autor:
Yeon Hee Park, Samir Lal, Jeong Eon Lee, Yoon-La Choi, Ji Wen, Sripad Ram, Ying Ding, Soo-Hyeon Lee, Eric Powell, Se Kyung Lee, Jong Han Yu, Keith A. Ching, Jae-Yong Nam, Seok Won Kim, Seok Jin Nam, Ji-Yeon Kim, Soo Youn Cho, Seri Park, Jinho Kim, Soohyn Hwang, Yu Jin Kim, Vinicius Bonato, Diane Fernandez, Shibing Deng, Shuoguo Wang, Hyuntae Shin, Eun-Suk Kang, Woong-Yang Park, Paul A. Rejto, Jadwiga Bienkowska, Zhengyan Kan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neoadjuvant chemotherapy is a therapeutic option for the treatment of breast cancer. Here, the authors characterize changes in the gene expression profiles and immune microenvironment in serial breast cancer biopsies taken before, during and after ne
Externí odkaz:
https://doaj.org/article/d34ef5fb3216481893b451cd685dff30
Autor:
Sripad Ram, Pamela Vizcarra, Pamela Whalen, Shibing Deng, C L Painter, Amy Jackson-Fisher, Steven Pirie-Shepherd, Xiaoling Xia, Eric L Powell
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0245638 (2021)
Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression in tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard of practice, is known to have several sh
Externí odkaz:
https://doaj.org/article/b8922c40f36d48b9a4bdddcab8658a90
Autor:
Mary Katherine Montgomery, John David, Haikuo Zhang, Sripad Ram, Shibing Deng, Vidya Premkumar, Lisa Manzuk, Ziyue Karen Jiang, Anand Giddabasappa
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252950 (2021)
Unlike the majority of cancers, survival for lung cancer has not shown much improvement since the early 1970s and survival rates remain low. Genetically engineered mice tumor models are of high translational relevance as we can generate tissue specif
Externí odkaz:
https://doaj.org/article/9e68815adf6744f5993de637520b8051
Autor:
Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K. Manzuk, Roberto Ortiz, Michael Hall, Kavon Noorbehesht, Sripad Ram, Timothy Affolter, Gabriel E. Troche, Nathan T. Ihle, Theodore Johnson, Youngwook Ahn, Manfred Kraus, Anand Giddabasappa
Publikováno v:
Molecular Cancer Therapeutics.
KRAS is one of the most commonly mutated oncogenes in lung, colorectal, and pancreatic cancers. Recent clinical trials directly targeting KRAS G12C presented encouraging results for a large population of non-small cell lung cancer (NSCLC), but resist
Two-color live cell imaging of a J774A.1 macrophage phagocytosing MDA-MB-453 cancer cells. Macrophages with surface-labeled CD45 (green) engulf three trastuzumab-opsonized MDA-MB-453 cells (red). Time is indicated at the top left in minutes:seconds f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb6bad3220ce20d8ba2f3fb507d1c32
https://doi.org/10.1158/1535-7163.22506069.v1
https://doi.org/10.1158/1535-7163.22506069.v1
Document containing supplementary methods, supplementary figure legends for supplementary movies and figures; Figure S1. Harvesting efficiency of cancer cells in macrophage:cancer cell co-cultures; Figure S2. Macrophage-mediated reduction of opsonize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285e9703e3d7d65438339efc3723743e
https://doi.org/10.1158/1535-7163.22506051.v1
https://doi.org/10.1158/1535-7163.22506051.v1
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Table S1. Mean ({plus minus}SD) Toxicokinetic Parameters for Ipilimumab and Novolumab in Cynomolgus Monkeys Table S2 - Differentially expressed genes in the heart of ipilimumab and nivolumab treated cynos (adjusted P-value {less than or equal to} 0.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3942b4f23d29af0107356ea8a8bc653c
https://doi.org/10.1158/1078-0432.22469919.v1
https://doi.org/10.1158/1078-0432.22469919.v1
Autor:
Bernard S. Buetow, Magali Guffroy, Martin Finkelstein, Nasir K. Khan, Puja Sapra, Andrea T. Hooper, William A. Meier, Frank Barletta, Matthew Martin, Steven W. Kumpf, Sripad Ram, Allison Vitsky, Jonathan Golas, Marc D. Roy, Changhua Ji
Supplemental Figure S1. Concentration versus time profiles of ipilimumab and nivolumab following four weekly intravenous dose administrations of 15 mg/kg or 20 mg/kg, respectively. Supplementary Figure S2. Hematoxylin and eosin stained sections of ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027a7f5962acdd0744c93d4421f906a4
https://doi.org/10.1158/1078-0432.22469916
https://doi.org/10.1158/1078-0432.22469916