Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Srinu, Tumpara"'
Autor:
Jan D. Zemtsovski, Srinu Tumpara, Sonja Schmidt, Vijith Vijayan, Andreas Klos, Robert Laudeley, Julia Held, Stephan Immenschuh, Florian M. Wurm, Tobias Welte, Hermann Haller, Sabina Janciauskiene, Nelli Shushakova
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundExcessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capaci
Externí odkaz:
https://doaj.org/article/44b182a20fed4dd3a42717018dafa97b
Autor:
Sabina Janciauskiene, Srinu Tumpara, Nils Helge Schebb, Falk F. R. Buettner, Malwina Mainka, Kokilavani Sivaraman, Stephan Immenschuh, Veronika Grau, Tobias Welte, Beata Olejnicka
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β
Externí odkaz:
https://doaj.org/article/3982131efe1046f8be0af6fdc1b06265
Autor:
Natalie Schwarz, Srinu Tumpara, Sabine Wrenger, Evrim Ercetin, Jürg Hamacher, Tobias Welte, Sabina Janciauskiene
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Elevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of various cancers. Herein, we investigated effects of exogenous AAT on non-small lung cancer cell lines with high (H1975) and very low (H661) baseline expres
Externí odkaz:
https://doaj.org/article/8b7d2f4e35ab458e8b9d5642d0b16ac7
Autor:
Kukuh Madyaningrana, Vijith Vijayan, Christoph Nikolin, Abid Aljabri, Srinu Tumpara, Elena Korenbaum, Harshit Shah, Metodi Stankov, Heiko Fuchs, Sabina Janciauskiene, Stephan Immenschuh
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102060- (2021)
Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high
Externí odkaz:
https://doaj.org/article/7ccb96f4d37c4118904fd1cf743814d1
Autor:
Srinu Tumpara, Matthias Ballmaier, Sabine Wrenger, Mandy König, Matthias Lehmann, Ralf Lichtinghagen, Beatriz Martinez-Delgado, Elena Korenbaum, David DeLuca, Nils Jedicke, Tobias Welte, Malin Fromme, Pavel Strnad, Jan Stolk, Sabina Janciauskiene
Publikováno v:
eLife, Vol 10 (2021)
Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its
Externí odkaz:
https://doaj.org/article/6bbbe2d057b14eb88142e880aeb3a6e6
Autor:
Lena Ostermann, Regina Maus, Jennifer Stolper, Lisanne Schütte, Konstantina Katsarou, Srinu Tumpara, Andreas Pich, Christian Mueller, Sabina Janciauskiene, Tobias Welte, Ulrich A. Maus
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Alpha-1 antitrypsin (AAT) is a major inhibitor of serine proteases in mammals. Therefore, its deficiency leads to protease–antiprotease imbalance and a risk for developing lung emphysema. Although therapy with human plasma-purified AAT attenuates A
Externí odkaz:
https://doaj.org/article/fc87a8d6b6744dbba82904f96af8ac6a
Autor:
Srinu Tumpara, Beatriz Martinez-Delgado, Gema Gomez-Mariano, Bin Liu, David S. DeLuca, Elena Korenbaum, Danny Jonigk, Frank Jugert, Florian M. Wurm, Maria J. Wurm, Tobias Welte, Sabina Janciauskiene
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provid
Externí odkaz:
https://doaj.org/article/d649110fad584ba68c3fdad1618e010c
Autor:
Srikanth Karnati, Gani Oruqaj, Harshavardhan Janga, Srinu Tumpara, Claudia Colasante, Paul P Van Veldhoven, Nancy Braverman, Adrian Pilatz, Thomas J Mariani, Eveline Baumgart-Vogt
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203466 (2018)
Despite the important functions of PPARγ in various cell types of the lung, PPARγ-deficiency in club cells induces only mild emphysema. Peroxisomes are distributed in a similar way as PPARγ in the lung and are mainly enriched in club and AECII cel
Externí odkaz:
https://doaj.org/article/8b4fd6fea18d41279e2508bb98c1b19b
Autor:
Nagoud, Schukfeh, Bin, Liu, David S, DeLuca, Srinu, Tumpara, Christoph, Nikolin, Stephan, Immenschuh, Benno M, Ure, Joachim F, Kuebler, Tobias, Welte, Dorothee, Viemann, Sabina M, Janciauskiene, Gertrud, Vieten
Publikováno v:
European journal of immunologyReferences.
Nowadays laparoscopic interventions enable the collection of resident macrophage populations out of the human cavities. We employed this technique to isolate pleural monocytes/macrophages from healthy young adults who underwent a correction of pectus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d27d1c2fc8a54329cb7b0d4ea4064741
https://pubmed.ncbi.nlm.nih.gov/36321537
https://pubmed.ncbi.nlm.nih.gov/36321537
Autor:
Sri Harsha Meghadri, Beatriz Martinez-Delgado, Lena Ostermann, Gema Gomez-Mariano, Sara Perez-Luz, Srinu Tumpara, Sabine Wrenger, David S. DeLuca, Ulrich A. Maus, Tobias Welte, Sabina Janciauskiene
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10425
The SERPINA1 gene encodes alpha1-antitrypsin (AAT), an acute phase glycoprotein and serine protease inhibitor that is mainly (80-90%) produced in the liver. Point mutations in the SERPINA1 gene can lead to the misfolding, intracellular accumulation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e24451cf15ad3068524414440d59fe