Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis

Autor: Ana M. Valdes, Srinivasarao Ravipati, Petros Pousinis, Cristina Menni, Massimo Mangino, Abhishek Abhishek, Victoria Chapman, David A. Barrett, Michael Doherty

Publikováno v: Journal of Lipid Research, Vol 59, Iss 9, Pp 1763-1770 (2018)

Omega-6 FAs are inflammatory mediators that are increased in joints with osteoarthritis (OA), but their association with OA progression is not yet well defined. To investigate the relationship between omega-6 FAs and knee OA, we measured with LC-MS t

Externí odkaz: https://doaj.org/article/d1350abd942e46a7aa4bc8e135ea98a0

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans

Autor: Juliette Harris, Abhishek Abhishek, Sarah Metrustry, Ayrun Nessa, Tim D. Spector, Srinivasarao Ravipati, Cristina Menni, Ana M. Valdes, Frances M K Williams, David A. Barrett, Victoria Chapman, Michael Doherty

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Valdes, A M, Ravipati, S, Menni, C, Abhishek, A, Metrustry, S, Harris, J, Nessa, A, Williams, F M K, Spector, T D, Doherty, M, Chapman, V & Barrett, D A 2017, ' Association of the resolvin precursor 17-HDHA, but not D-or E-series resolvins, with heat pain sensitivity and osteoarthritis pain in humans ', Scientific Reports, vol. 7, no. 1, 10748 . https://doi.org/10.1038/s41598-017-09516-3
Scientific Reports

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c4c1be24dd13b3bb9475eb19af8b73
http://link.springer.com/article/10.1038/s41598-017-09516-3

Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation

Autor: H.M. de Visser, Srinivasarao Ravipati, F.P.J.G. Lafeber, David A. Barrett, Harrie Weinans, Simon C. Mastbergen, Victoria Chapman, Ferran Casbas Pinto, P.M.J. Welsing

Publikováno v: PLoS ONE [E], 13(4). Public Library of Science
PLoS ONE, 13(4)
PLoS ONE, Vol 13, Iss 4, p e0196308 (2018)
PLoS ONE

Objective Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2204dfc46d7a88339b24167bb6e7f0c
https://dspace.library.uu.nl/handle/1874/363824

Erratum to: A methodology for elucidating regulatory mechanisms leading to changes in lipid profiles

Autor: T. Charles Hodgman, Srinivasarao Ravipati, David A. Barrett, Ferran Casbas Pinto

Publikováno v: Metabolomics. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587188f7126de203cc4d477f21e691de
https://doi.org/10.1007/s11306-017-1226-7

Quantification of systemic and local lipid-derived inflammatory mediators in a rat OA mode l

Autor: Srinivasarao Ravipati, David A. Barrett, Harrie Weinans, P.M.J. Welsing, Victoria Chapman, F.P.J.G. Lafeber, H.M. de Visser, S.C. Mastbergen

Publikováno v: Osteoarthritis and Cartilage. 25:S98-S99

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::509c88c5824ac9acfab8cefefd81ceb8
https://doi.org/10.1016/j.joca.2017.02.158