Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Srinivasan Venkatachalan"'
Autor:
Matthew H. Daniels, Goran Malojcic, Susan L. Clugston, Brett Williams, Marie Coeffet-Le Gal, Xin-Ru Pan-Zhou, Srinivasan Venkatachalan, Jean-Christophe Harmange, Mark Ledeboer
Publikováno v:
Journal of Medicinal Chemistry. 65:3575-3596
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic human disease, but to date, only one therapy (tolvaptan) is approved to treat kidney cysts in ADPKD patients. Cyclin-dependent kinase 5 (CDK5), an atypical member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44486911fc4d2a0b0f078ecd2b71f99
https://doi.org/10.1021/acs.jmedchem.1c02069
https://doi.org/10.1021/acs.jmedchem.1c02069
Autor:
Amy D. Westerling-Bui, Eva Maria Fast, Thomas W. Soare, Srinivasan Venkatachalan, Michael DeRan, Alyssa B. Fanelli, Sergii Kyrychenko, Hien Hoang, Grinal M. Corriea, Wei Zhang, Maolin Yu, Matthew Daniels, Goran Malojcic, Xin-Ru Pan-Zhou, Mark W. Ledeboer, Jean-Christophe Harmange, Maheswarareddy Emani, Thomas T. Tibbitts, John F. Reilly, Peter Mundel
Publikováno v:
Science Advances. 8
Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to animal models with unclear translata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40449dd6e041ef112e7753de2cea4d8c
https://doi.org/10.1126/sciadv.abj5633
https://doi.org/10.1126/sciadv.abj5633
Autor:
Wei Zhang, Michael DeRan, Goran Malojčić, Xin-Ru Pan-Zhou, Maheswarareddy Emani, Jean-Christophe Harmange, Alyssa B. Fanelli, Hien Hoang, Peter Mundel, John F. Reilly, Mark W. Ledeboer, Amy Westerling-Bui, Maolin Yu, Srinivasan Venkatachalan, Sergii Kyrychenko, Thomas T. Tibbitts, Eva Maria Fast, Thomas W. Soare, Grinal M. Corriea
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims A major challenge in drug discovery is gaining confidence in the human relevance of pre-clinical animal studies. While human iPSC-derived organoids offer exciting opportunities to address this, concerns about applicability and sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b0f85b8aa6784f9df0c3d73f0c2b00
https://doi.org/10.1093/ndt/gfaa139.so038
https://doi.org/10.1093/ndt/gfaa139.so038