Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Srinivasan Rengachari"'
Autor:
Srinivasan Rengachari, Sandra Schilbach, Thangavelu Kaliyappan, Jerome Gouge, Kristina Zumer, Juliane Schwarz, Henning Urlaub, Christian Dienemann, Alessandro Vannini, Patrick Cramer
Publikováno v:
Nature structural & molecular biology.
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology
RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes. Whereas Pol II initiation at protein-coding genes has been studied in detail, Pol II initiation at non-coding genes, such as small nuclear RNA (snRNA) g
Publikováno v:
Biological Chemistry
Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214056b116f478def74a8d716b5d703e
https://hdl.handle.net/21.11116/0000-000D-44FF-821.11116/0000-000D-4501-4
https://hdl.handle.net/21.11116/0000-000D-44FF-821.11116/0000-000D-4501-4
Autor:
Srinivasan, Rengachari, Sandra, Schilbach, Thangavelu, Kaliyappan, Jerome, Gouge, Kristina, Zumer, Juliane, Schwarz, Henning, Urlaub, Christian, Dienemann, Alessandro, Vannini, Patrick, Cramer
Publikováno v:
Nature structuralmolecular biology. 29(12)
RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes. Whereas Pol II initiation at protein-coding genes has been studied in detail, Pol II initiation at non-coding genes, such as small nuclear RNA (snRNA) g
Publikováno v:
Nature
nature
nature
Mediator is a conserved coactivator complex that enables the regulated initiation of transcription at eukaryotic genes1–3. Mediator is recruited by transcriptional activators and binds the pre-initiation complex (PIC) to stimulate the phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfe1c416b89b153e5212820cc3b8edb
https://hdl.handle.net/21.11116/0000-0009-4825-D21.11116/0000-0008-707B-021.11116/0000-000A-70F4-4
https://hdl.handle.net/21.11116/0000-0009-4825-D21.11116/0000-0008-707B-021.11116/0000-000A-70F4-4
Mediator is a conserved coactivator that enables regulated transcription initiation from eukaryotic protein-coding genes1-3. Mediator is recruited by transcriptional activators and binds the pre-initiation complex (PIC) to stimulate RNA polymerase II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccee6ec8a3536a36b26c3d7c67b14a52
https://doi.org/10.1101/2021.03.11.435010
https://doi.org/10.1101/2021.03.11.435010
Autor:
Srinivasan, Rengachari, Sandra, Schilbach, Shintaro, Aibara, Christian, Dienemann, Patrick, Cramer
Publikováno v:
Nature. 594(7861)
Mediator is a conserved coactivator complex that enables the regulated initiation of transcription at eukaryotic genes
Autor:
Antje Margret Wengner, Hans Briem, Stefan Gradl, Srinivasan Rengachari, Tobias Heinrich, Carl Friedrich Nising, Detlef Stöckigt, Franz von Nussbaum, Ulf Bömer, Julien Lefranc, Benjamin Bader, Anne Mengel, Dominik Mumberg, Roman C. Hillig, Volker K Schulze, Florian Prinz, Daniel Panne, József Bálint, Horst Irlbacher
Publikováno v:
Journal of medicinal chemistry. 63(2)
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKe are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particu
Autor:
Elise Caron, Srinivasan Rengachari, Silvia Groiss, Juliette M. Devos, Nathalie Grandvaux, Daniel Panne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cytokines interact with their receptors and activate JAK–STAT signaling pathways that lead to changes in gene expression. In mammals, there are seven STATs that have arisen due to gene duplication and genetic drift. STATs have similar
Autor:
Srinivasan Rengachari, Esther Ortega, Naghmeh Hoghoughi, Saadi Khochbin, Daniel Panne, Alex S. Holehouse, Ziad Ibrahim, Jonathan Gaucher
Publikováno v:
Nature
Nature, 2018, 562 (7728), pp.538-544. ⟨10.1038/s41586-018-0621-1⟩
Nature, Nature Publishing Group, 2018, 562 (7728), pp.538-544. ⟨10.1038/s41586-018-0621-1⟩
Nature, 2018, 562 (7728), pp.538-544. ⟨10.1038/s41586-018-0621-1⟩
Nature, Nature Publishing Group, 2018, 562 (7728), pp.538-544. ⟨10.1038/s41586-018-0621-1⟩
The transcriptional co-activator p300 is a histone acetyltransferase (HAT) that is typically recruited to transcriptional enhancers and regulates gene expression by acetylating chromatin. Here we show that the activation of p300 directly depends on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4401ff164a8607e8d67e3ac7cfa728d
https://hal.science/hal-02325842
https://hal.science/hal-02325842
Autor:
Philipp, Aschauer, Srinivasan, Rengachari, Joerg, Lichtenegger, Matthias, Schittmayer, Krishna Mohan Padmanabha, Das, Nicole, Mayer, Rolf, Breinbauer, Ruth, Birner-Gruenberger, Christian C, Gruber, Robert, Zimmermann, Karl, Gruber, Monika, Oberer
Publikováno v:
Biochimica et biophysica acta. 1861(5)
Monoglyceride lipases (MGLs) are a group of α/β-hydrolases that catalyze the hydrolysis of monoglycerides (MGs) into free fatty acids and glycerol. This reaction serves different physiological functions, namely in the last step of phospholipid and