Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Srinivasan Rajalakshmi"'
Autor:
Walvekar, Adhish S., Kadamur, Ganesh, Sreedharan, Sreesa, Gupta, Ritu, Srinivasan, Rajalakshmi, Laxman, Sunil *
Publikováno v:
In Journal of Biological Chemistry 25 December 2020 295(52):18390-18405
Autor:
Srinivasan, Rajalakshmi1 (AUTHOR), Walvekar, Adhish S.1 (AUTHOR), Rashida, Zeenat1 (AUTHOR), Seshasayee, Aswin2 (AUTHOR) aswin@ncbs.res.in, Laxman, Sunil1 (AUTHOR) aswin@ncbs.res.in
Publikováno v:
PLoS Genetics. 12/30/2020, Vol. 16 Issue 12, p1-28. 28p.
Akademický článek
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How cells manage biomolecule supply to enable constructive metabolism for growth is a fundamental question. Methionine directly activates genomic programs where translation and metabolism are induced. In otherwise amino acid limitations, methionine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::02ac4cf7895ae126fceaa2375248ba84
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Aroon Yusuf, Dittakavi S. R. Sarma, Ramesh Vanama, Victor Ling, Janarthanan Kankesan, Prema M. Rao, Srinivasan Rajalakshmi, Jake J. Thiessen
Publikováno v:
Carcinogenesis. 25:425-430
Studies in our laboratory on the role of P-glycoprotein (Pgp, coded by mdr1 gene) have led to the hypothesis that over-expression of Pgp is closely associated with the development of cancer. It was conceived therefore that inhibitors of Pgp should in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5dd880edd6001a87c796342c0eacfc
https://doi.org/10.1093/carcin/bgh018
https://doi.org/10.1093/carcin/bgh018
Publikováno v:
Molecular Carcinogenesis. 24:188-196
Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c223872b48f5104ab7aad1b497634a
https://doi.org/10.1002/(sici)1098-2744(199903)24:3<188::aid-mc5>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199903)24:3<188::aid-mc5>3.0.co
Autor:
Paolo Pani, Sergio Laconi, Ali R. Jahangir, Ezio Laconi, Francesca Sanna, Srinivasan Rajalakshmi, Prema M. Rao, Aroon Yusuf, Antonio Monni, Dittakavi S. R. Sarma
Publikováno v:
Journal of Hepatology. 26:203-208
Background: Orotic acid (OA) is able to inhibit hepatocyte proliferation in vivo induced by 23 partial hepatectomy. The present studies were aimed at establishing: (i) whether OA also inhibits hepatocyte proliferation induced by a direct mitogen and,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d647ec6bd922c0238efb0bda592b4f10
https://doi.org/10.1016/s0168-8278(97)80027-x
https://doi.org/10.1016/s0168-8278(97)80027-x
Autor:
Maria Antonietta Seddaiu, M M Simile, M.R. De Miglio, Lucia Daino, Rosa Maria Pascale, D.S.R. Sarma, Srinivasan Rajalakshmi, A. Nufris, Francesco Feo, P.M. Rao
Publikováno v:
Scopus-Elsevier
Chemoprevention of liver carcinogenesis by S-adenosyl-L-methionine (SAM) was studied in F344 male rats. The rats were given 1,2-dimethylhydrazine (1,2-DMH) 2 HCl (100 mg/kg, i.p.) 18 h after two-thirds hepatectomy. One week later they were fed a semi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd87a0de2264d3ad84111f63cd22e23
https://doi.org/10.1093/carcin/16.2.427
https://doi.org/10.1093/carcin/16.2.427
Publikováno v:
Molecular Carcinogenesis. 10:237-245
Our earlier studies demonstrated that the beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase gene is hypomethylated and overexpressed in hepatic nodules initiated by 1,2-dimethylhydrazine (1,2-DMH). The study presented here examined whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb87067d7dcdc3a084471f68760c3ea1
https://doi.org/10.1002/mc.2940100408
https://doi.org/10.1002/mc.2940100408