Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Srinivasan MA"'
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Autor:
Rodhan Patke, Anna E. Harris, Corinne L. Woodcock, Rachel Thompson, Rute Santos, Amber Kumari, Cinzia Allegrucci, Nathan Archer, Lorraine J. Gudas, Brian D. Robinson, Jenny L. Persson, Rupert Fray, Jennie Jeyapalan, Catrin S. Rutland, Emad Rakha, Srinivasan Madhusudan, Richard D. Emes, Musalwa Muyangwa-Semenova, Mansour Alsaleem, Simone de Brot, William Green, Hari Ratan, Nigel P. Mongan, Jennifer Lothion-Roy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 56, Iss , Pp 101032- (2024)
Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen
Externí odkaz:
https://doaj.org/article/f224ca60609a48d0bd38942bd1a03543
Publikováno v:
Advanced Materials Interfaces, Vol 11, Iss 27, Pp n/a-n/a (2024)
Abstract Extraction of graphene and graphene derivatives from non‐toxic, biocompatible, eco‐friendly, and biodegradable resources with a one‐step production process is a challenge. This work is the first attempt at the one‐step graphenization
Externí odkaz:
https://doaj.org/article/8c377852c66b4e2288dbb067ada5842e
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Advanced epithelial ovarian cancer is the commonest cause of gynaecological cancer deaths. First-line treatment for advanced disease includes a combination of platinum-taxane chemotherapy (post-operatively or peri-operatively) and maximal debulking s
Externí odkaz:
https://doaj.org/article/18a9294bed0b4d7f96acf60e2423d552
Autor:
Srinivasan Manoj Kumar, Briska Jifrina Premnath, Ramya Parimelazhagan, Chandramohan Govindasamy, Kamala-Kannan Seralathan, Nalini Namasivayam
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 2, Pp 103029- (2024)
Objectives: The current research explores the anticancer effects of pH sensitive CVC-ZnO QDs (Carvacrol-loaded Zinc Oxide Quantum Dots) on DMBA induced mammary carcinoma in rats. Methods: Female SD rats were used, and mammary cancer was induced by ch
Externí odkaz:
https://doaj.org/article/aefda00bc0394a2096e27977f8250e6c
Autor:
Venkatesan Kamalesh Balakumar, Alamelu Saravanan, Priya Sivamathi Rathna, Jayaseelan Nivedha, Kamaraj Sathish-Kumar, Srinivasan Manoj Kumar, Alshehri Mohammed Ali, Panneerselvam Chellasamy, Saif Ahmed, Periyasamy Selvendiran
Publikováno v:
Green Processing and Synthesis, Vol 12, Iss 1, Pp 61-9 (2023)
Externí odkaz:
https://doaj.org/article/5e735335e4774acfada0532db02991d3
Autor:
Ayat Lashen, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5053 (2024)
Cyclin-dependent kinase 2 (CDK2) is a key cell cycle regulator, with essential roles during G1/S transition. The clinicopathological significance of CDK2 in ductal carcinomas in situ (DCIS) and early-stage invasive breast cancers (BCs) remains largel
Externí odkaz:
https://doaj.org/article/a68b1f1a502d4ffd9994f0c77aec945b
Autor:
Ayat Lashen, Abdulbaqi Al-Kawaz, Jennie N Jeyapalan, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Michael Toss, Andrew R Green, Nigel P Mongan, Sudha Sharma, Mohammad R Akbari, Emad A Rakha, Srinivasan Madhusudan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 47, Iss , Pp 100957- (2024)
RECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial term
Externí odkaz:
https://doaj.org/article/49f4f85691f14003931c5bd5105aab22
Autor:
Mashael Algethami, Michael S. Toss, Corinne L. Woodcock, Chandar Jaipal, Juliette Brownlie, Ahmed Shoqafi, Adel Alblihy, Katia A. Mesquita, Andrew R. Green, Nigel P. Mongan, Jennie N. Jeyapalan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have eval
Externí odkaz:
https://doaj.org/article/c5ad0bb1f1a94ed0a4920ebd299adf4e
Autor:
Ayat Lashen, Mashael Algethami, Shatha Alqahtani, Ahmed Shoqafi, Amera Sheha, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4060 (2024)
Cyclin-dependent kinases (CDK2, CDK4, CDK6), cyclin D1, cyclin E1 and phosphorylated retinoblastoma (pRB1) are key regulators of the G1/S cell cycle checkpoint and may influence platinum response in ovarian cancers. CDK2/4/6 inhibitors are emerging t
Externí odkaz:
https://doaj.org/article/ca15e7d36f5e414faea844abed80e1fc