Improved Mitochondrial Bioenergetics by Anesthetic Preconditioning During and After 2 Hours of 27°C Ischemia in Isolated Hearts

Autor: Srinivasan G. Varadarajan, David F. Stowe, Jianzhong An, Amadou K.S. Camara, Samhita S. Rhodes, Matthias L. Riess

Publikováno v: Journal of Cardiovascular Pharmacology. 46:280-287

We examined if sevoflurane given before cold ischemia of intact hearts (anesthetic preconditioning, APC) affords additional protection by further improving mitochondrial energy balance and if this is abolished by a mitochondrial KATP blocker. NADH an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180101579db0d4c2cd82d3221be3a03d
https://doi.org/10.1097/01.fjc.0000175238.18702.40

Inhibition of Na+/H+ isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage

Autor: Jianzhong An, Qun Chen, Srinivasan G. Varadarajan, David F. Stowe, Enis Novalija, Pierre Schelling, James S. Heisner, Amadou K.S. Camara

Publikováno v: The Journal of Heart and Lung Transplantation. 21:374-382

Cardiac ischemia-reperfusion activates Na(+)/H(+) exchange; excess Na(+) and the resulting Ca(2+) overload, through reverse Na(+)/Ca(2+) exchange, cause cellular injury and cardiac dysfunction. We postulated that inhibiting the Na(+)/H(+) isoform-1 e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ef744deded94d58f06140988949a6a
https://doi.org/10.1016/s1053-2498(01)00383-7

Ischemic and anesthetic preconditioning reduces cytosolic [Ca2+] and improves Ca2+responses in intact hearts

Autor: Enis Novalija, Srinivasan G. Varadarajan, Jianzhong An, David F. Stowe

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 281:H1508-H1523

Ca+loading during reperfusion after myocardial ischemia is linked to reduced cardiac function. Like ischemic preconditioning (IPC), a volatile anesthetic given briefly before ischemia can reduce reperfusion injury. We determined whether IPC and sevof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017e671315bbe2464e7454a68c5e084a
https://doi.org/10.1152/ajpheart.2001.281.4.h1508

Anesthesia and Disease States, Part II

Autor: Christopher Plambeck, Vikram Khatri, Srinivasan G. Varadarajan, Christine M. Zainer

Chapter 4 contains 62 questions and answers regarding anesthesia and disease states.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da616cbe0c6961bc4e3c8c8450ea9669
https://doi.org/10.1093/med/9780199733859.003.0004

Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels

Autor: David F. Stowe, Andre Heinen, Samhita S. Rhodes, Srinivasan G. Varadarajan, Amadou K.S. Camara, Matthias L. Riess, Mohammed Aldakkak

Publikováno v: American journal of physiology. Heart and circulatory physiology, 293(3), H1400-H1407. American Physiological Society

Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O2 concentration, redox state, and activity of the mitochondrial complexes. It is well known that the FADH2-linked substrate succinate induces reverse electron flo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10aa293de291590350ee822208eb1a3f
https://pubmed.ncbi.nlm.nih.gov/17513497