Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Srinivasan Dasarathy"'
Autor:
Amy H. Attaway, Rocio Lopez, Nicole Welch, Annette Bellar, Umur Hatipoğlu, Joe Zein, Marielle PKJ Engelen, Srinivasan Dasarathy
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder with systemic consequences that can cause a muscle loss phenotype (MLP), which is characterized by the loss of muscle mass, muscle strength, or loss o
Externí odkaz:
https://doaj.org/article/592798e4bdff47c89243dd29b2f2ee27
Publikováno v:
Gut and Liver, Vol 18, Iss 2, Pp 201-208 (2024)
Electronic health records (EHRs) have been increasingly adopted in clinical practices across the United States, providing a primary source of data for clinical research, particularly observational cohort studies. EHRs are a high-yield, low-maintenanc
Externí odkaz:
https://doaj.org/article/14309d2ac06245af9eb508a1124b45a8
Autor:
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Gulshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Publikováno v:
eLife, Vol 12 (2024)
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 ex
Externí odkaz:
https://doaj.org/article/3c5d86faa2f749f9b1ff225029440203
Autor:
Amy H. Attaway, Annette Bellar, Nicole Welch, Jinendiran Sekar, Avinash Kumar, Saurabh Mishra, Umur Hatipoğlu, Merry‐Lynn McDonald, Elizabeth A. Regan, Jonathan D. Smith, George Washko, Raúl San José Estépar, Peter Bazeley, Joe Zein, Srinivasan Dasarathy
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 2, Pp 1083-1095 (2023)
Abstract Background Sarcopenia, or loss of skeletal muscle mass and decreased contractile strength, contributes to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). The severity of sarcopenia in COPD is variable,
Externí odkaz:
https://doaj.org/article/62aaf16a8ff94490b943c20b2a887b98
Autor:
Adam Kim, Martí Ortega-Ribera, Megan R. McMullen, Annette Bellar, Moyinoluwa Taiwo, Vai Pathak, David Streem, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, Vidula Vachharajani, Laura E. Nagy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107133- (2023)
Summary: Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular me
Externí odkaz:
https://doaj.org/article/d98479cccd364976b87e0478ee4d52c3
Autor:
Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Patients with acute alcohol‐associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformat
Externí odkaz:
https://doaj.org/article/881a67875696428382c69cb550c103a6
Autor:
Amy Attaway, Nicole Welch, Dhweeja Dasarathy, Jocelyn Amaya‐Hughley, Annette Bellar, Michelle Biehl, Siddharth Dugar, Marielle P.K.J. Engelen, Joe Zein, Srinivasan Dasarathy
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 5, Pp 2436-2446 (2022)
Abstract Background Chronic disease causes skeletal muscle loss that contributes to morbidity and mortality. There are limited data on the impact of dynamic muscle loss on clinical outcomes in COVID‐19. We hypothesized that acute COVID‐19‐relat
Externí odkaz:
https://doaj.org/article/3ee91ed2c25244aaaf1f1954512bf357
Autor:
Wanzhu Tu, Samer Gawrieh, Srinivasan Dasarathy, Mack C. Mitchell, Douglas A. Simonetto, Kavish R. Patidar, Craig J. McClain, Ramon Bataller, Gyongyi Szabo, Qing Tang, Bruce A. Barton, Svetlana Radaeva, Arun J. Sanyal, Vijay Shah
Publikováno v:
Contemporary Clinical Trials Communications, Vol 32, Iss , Pp 101074- (2023)
Background: Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care for patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated inflammation
Externí odkaz:
https://doaj.org/article/4203b99fa20a49bd8563292dfc456ba2
Autor:
Julia Y. Payne, Naim Alkhouri, Phuc Le, Michael B. Rothberg, Prido Polanco, Celine Sakkal, Srinivasan Dasarathy
Publikováno v:
Hepatology Communications, Vol 7, Iss 1, Pp e0019-e0019 (2023)
Patients with metabolic syndrome (MetS) have a higher risk for NASH and significant fibrosis. Presence of NASH and advanced fibrosis are associated with adverse outcomes in patients with NAFLD. Using a noninvasive method, we determined the prevalence
Externí odkaz:
https://doaj.org/article/5cb4d59bebe846fab154a88fbb16348c
Autor:
Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Externí odkaz:
https://doaj.org/article/62602ca604e54c7997de01962de6b453